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  4. BMP8A Antibody

BMP8A Antibody

  • 中文名稱：
    BMP8A兔多克隆抗體
  • 貨號：
    CSB-PA256187
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from COLO cells, using BMP8A antibody.
    • Immunofluorescence analysis of A549 cells, using BMP8A antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) BMP8A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from C-terminal of Human BMP8A.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT.; Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including spermatogenesis, osteogenesis, steroidogenesis as well as regulation of energy balance. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. In addition, activates the SMAD2/3 pathway.
  • 基因功能參考文獻(xiàn)：
    1. Authors found that Bmp8a, but not Bmp8b, was expressed predominantly in the neonatal mouse spermatogonia. Although most BMPs induce activation of SMADs 1, 5, and 8 (SMAD1/5/8), but not SMADs 2 and 3 (SMAD2/3), they found that BMP8A induced signaling through both sets of transcription factors. PMID: 28465413
    2. Observational study of gene-disease association. (HuGE Navigator) PMID: 20424473
    3. Observational study of gene-disease association. (HuGE Navigator) PMID: 20237496
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 21650

    KEGG: hsa:353500

    STRING: 9606.ENSP00000327440

    UniGene: Hs.472497