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  4. Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) ELISA kit

Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) ELISA kit

  • 中文名稱：
    人癌胚抗原相關(guān)細胞粘附分子8(CEACAM8)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL005168HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人癌胚抗原相關(guān)細胞粘附分子8(CEACAM8)酶聯(lián)免疫試劑盒（CSB-EL005168HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的CEACAM8含量。CEACAM8，也稱為CD66b，是免疫球蛋白超家族的一員，主要在粒細胞中表達。它通過調(diào)節(jié)細胞間粘附和信號傳導(dǎo)參與免疫反應(yīng)，尤其在腫瘤微環(huán)境中發(fā)揮重要作用。CEACAM8的研究機制涉及其在腫瘤中的調(diào)節(jié)機制、免疫信號機制以及與多種疾病如乳腺癌、宮頸癌和膀胱癌的關(guān)系。試劑盒檢測范圍為0.625 ng/mL-40 ng/mL，適用于體外檢測多種生物樣本中CEACAM8的表達水平，可為研究中性粒細胞介導(dǎo)的免疫反應(yīng)機制、炎癥相關(guān)疾病模型建立及腫瘤微環(huán)境調(diào)控等基礎(chǔ)科研領(lǐng)域提供可靠工具，其定量數(shù)據(jù)亦可作為探索CEACAM8作為炎癥或腫瘤相關(guān)生物標志物的研究依據(jù)。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Carcinoembryonic antigen CGM6 ELISA Kit; Carcinoembryonic antigen gene family member 6 ELISA Kit; Carcinoembryonic antigen related cell adhesion molecule 8 ELISA Kit; Carcinoembryonic antigen-related cell adhesion molecule 8 ELISA Kit; CD 66b ELISA Kit; CD 67 ELISA Kit; CD66b ELISA Kit; CD66b antigen ELISA Kit; CD67 ELISA Kit; CD67 antigen ELISA Kit; CEACAM 8 ELISA Kit; CEACAM8 ELISA Kit; CEAM8_HUMAN ELISA Kit; CGM 6 ELISA Kit; CGM6 ELISA Kit; NCA 95 ELISA Kit; NCA95 ELISA Kit; Non-specific cross-reacting antigen NCA-95 ELISA Kit; Nonspecific cross reacting antigen NCA 95 ELISA Kit; Nonspecific cross reacting antigen NCA95 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.625 ng/mL-40 ng/mL
  • 靈敏度：
    0.156 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Others
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human CEACAM8 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %91
    Range %85-96
    1:2Average %96
    Range %92-103
    1:4Average %102
    Range %95-108
    1:8Average %88
    Range %86-91
  • 回收率：
    The recovery of human CEACAM8 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9186-95
    EDTA plasma (n=4)9794-101
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    402.322 2.525 2.424 2.273
    201.989 1.966 1.978 1.827
    101.365 1.481 1.423 1.272
    50.975 1.052 1.014 0.863
    2.50.603 0.625 0.614 0.463
    1.250.369 0.347 0.358 0.207
    0.6250.272 0.280 0.276 0.125
    00.146 0.155 0.151
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Heterophilic interaction with CEACAM8 occurs in activated neutrophils.
  • 基因功能參考文獻：
    1. Increased CD66b positive tumor-infiltrating neutrophils (CD66b + TINs) was significantly associated with presence of metastasis, S stage, and nonseminomatous germ cell tumor diagnosis. PMID: 27863478
    2. Data suggest ways in which carcinoembryonic antigen-related cell adhesion molecules CEACAM6 and CEACAM8 regulate the biological functions of one another. PMID: 26483485
    3. Granulocytes from type 2 diabetes patients display higher granulocyte cell surface expression of CD66b compared with values of healthy controls. PMID: 23686079
    4. The highly elevated gene expression of CEACAM6 and CEACAM8 in primary myelofibrosis can serve as molecular markers of myelofibrotic transformation. PMID: 21470677
    5. All the leukemic samples showed overexpression of CEACAM6 and 8 when compared with normal granulocytes. PMID: 17909799
    6. CD66b molecules are involved in regulating adhesion and activation of eosinophils, possibly through their localization in lipid rafts and interaction with other cell surface molecules, such as CD11b. PMID: 18056392

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Cell surface.
  • 蛋白家族：
    Immunoglobulin superfamily, CEA family
  • 組織特異性：
    Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1820

    OMIM: 615747

    KEGG: hsa:1088

    STRING: 9606.ENSP00000244336

    UniGene: Hs.41