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  4. CEACAM8 Recombinant Monoclonal Antibody

CEACAM8 Recombinant Monoclonal Antibody

  • 中文名稱：
    CEACAM8重組抗體
  • 貨號：
    CSB-RA937940A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Overlay Peak curve showing A549 cells surface stained with CSB-RA937940A0HU (red line) at 1:50. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CEACAM8重組單克隆抗體（CUSABIO貨號：CSB-RA937940A0HU）是針對粒細(xì)胞特異性標(biāo)志物CEACAM8開發(fā)的高特異性檢測工具。CEACAM8作為癌胚抗原相關(guān)細(xì)胞黏附分子家族成員，在中性粒細(xì)胞活化、炎癥反應(yīng)及病原體防御中發(fā)揮重要作用。本產(chǎn)品經(jīng)過嚴(yán)格的ELISA和流式細(xì)胞術(shù)（FC）驗(yàn)證，能特異性識別天然構(gòu)象的CEACAM8蛋白，F(xiàn)C推薦使用稀釋比為1:50-1:200，適用于體外檢測人源樣本中CEACAM8的表達(dá)水平。在科研領(lǐng)域，該抗體可應(yīng)用于粒細(xì)胞亞群分型、炎癥相關(guān)免疫細(xì)胞功能研究，以及感染性疾病或自身免疫性疾病模型中粒細(xì)胞活化機(jī)制的探索。其重組單克隆特性保障了批次間的高度一致性，為細(xì)胞表面標(biāo)記分析、免疫應(yīng)答機(jī)制研究提供可靠工具，助力研究者深入解析CEACAM8在先天免疫調(diào)控中的生物學(xué)功能。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b), CEACAM8, CGM6
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from Human CEACAM8
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    24H12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Heterophilic interaction with CEACAM8 occurs in activated neutrophils.
  • 基因功能參考文獻(xiàn)：
    1. Increased CD66b positive tumor-infiltrating neutrophils (CD66b + TINs) was significantly associated with presence of metastasis, S stage, and nonseminomatous germ cell tumor diagnosis. PMID: 27863478
    2. Data suggest ways in which carcinoembryonic antigen-related cell adhesion molecules CEACAM6 and CEACAM8 regulate the biological functions of one another. PMID: 26483485
    3. Granulocytes from type 2 diabetes patients display higher granulocyte cell surface expression of CD66b compared with values of healthy controls. PMID: 23686079
    4. The highly elevated gene expression of CEACAM6 and CEACAM8 in primary myelofibrosis can serve as molecular markers of myelofibrotic transformation. PMID: 21470677
    5. All the leukemic samples showed overexpression of CEACAM6 and 8 when compared with normal granulocytes. PMID: 17909799
    6. CD66b molecules are involved in regulating adhesion and activation of eosinophils, possibly through their localization in lipid rafts and interaction with other cell surface molecules, such as CD11b. PMID: 18056392

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  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Cell surface.
  • 蛋白家族：
    Immunoglobulin superfamily, CEA family
  • 組織特異性：
    Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1820

    OMIM: 615747

    KEGG: hsa:1088

    STRING: 9606.ENSP00000244336

    UniGene: Hs.41