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  4. Human Delta-like protein 3(DLL3) ELISA kit

Human Delta-like protein 3(DLL3) ELISA kit

  • 中文名稱：
    人δ樣蛋白3(DLL3)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL006948HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人δ樣蛋白3(DLL3)酶聯(lián)免疫試劑盒（CSB-EL006948HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的DLL3含量。DLL3（δ樣蛋白3）是一種在多種腫瘤組織中異常高表達的膜蛋白，正常組織中表達有限，這使其成為有潛力的腫瘤治療靶點。研究主要圍繞阻斷其與 Notch 信號通路相互作用，抑制腫瘤細胞增殖、存活、遷移等，為癌癥治療提供新思路。試劑盒檢測范圍為18.75 pg/mL-1200 pg/mL，適用于基礎科研中探索DLL3在腫瘤微環(huán)境、干細胞分化或疾病生物標志物篩選等方向的作用機制，為體外研究提供可靠的蛋白表達水平數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Delta Drosophila like 3 ELISA Kit; Delta like 3 Drosophila ELISA Kit; Delta like 3 homolog Drosophila ELISA Kit; Delta like 3 protein ELISA Kit; Delta like protein 3 precursor ELISA Kit; Delta-like protein 3 ELISA Kit; Delta3 ELISA Kit; Dll3 ELISA Kit; DLL3_HUMAN ELISA Kit; Drosophila Delta homolog 3 ELISA Kit; SCDO1 ELISA Kit; SCOD1 ELISA Kit; Spondylocostal dysostosis autosomal recessive ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    18.75 pg/mL-1200 pg/mL
  • 靈敏度：
    4.68 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Developmental Biology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human DLL3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:5Average %105
    Range %100-112
    1:10Average %97
    Range %91-105
    1:20Average %93
    Range %89-100
    1:40Average %95
    Range %90-100
  • 回收率：
    The recovery of human DLL3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8984-93
    EDTA plasma (n=4)9691-100
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1OD2AverageCorrected
    12002.199 2.354 2.277 2.134
    6001.714 1.811 1.763 1.620
    3001.172 1.104 1.138 0.995
    1500.698 0.674 0.686 0.543
    750.425 0.407 0.416 0.273
    37.50.310 0.329 0.320 0.177
    18.750.207 0.219 0.213 0.070
    00.141 0.145 0.143
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
  • 基因功能參考文獻：
    1. these results reveal that DLL3 is expressed in tumor specimens from most patients with small cell lung cancer PMID: 29290251
    2. Results indicated that DLL3 expression was silenced in hepatocellular carcinoma (HCC) cells by DNA methylation and was more readily affected by histone acetylation than histone methylation (H3K9me2 or H3K27me3). PMID: 29512761
    3. our results indicated epidermal growth factor-like domain multiple 7 protein participates in growth hormone-secreting pituitary adenoma proliferation and invasion regulation via Notch2/DLL3 signaling pathway. These findings raised the possibility that epidermal growth factor-like domain multiple 7 protein might serve as a useful biomarker to assess growth hormone-secreting pituitary adenoma invasion and prognosis PMID: 28705113
    4. The Dll3 was rarely detectable in the para-carcinoma tissues, but positive in 82.1% of non-small cell cancer tissues. PMID: 28007595
    5. Both global haplotype and individual haplotype analyses showed that the haplotypes of SNP1/SNP2/SNP3/SNP4/SNP5 did not correlate with the disease (P >0.05). Together, these data suggest that genetic variants of the DLL3 gene are not associated with CS in the Chinese Han population. PMID: 27472720
    6. DLL3 was silenced by methylation in human human hepatocellular carcinoma and it negatively regulates the growth of human hepatocellular carcinoma cells. PMID: 23337976
    7. We suggest that the three human DLL3 mutations associated with spondylocostal dysplasia are also functionally equivalent to the Dll3(neo) null allele in mice. PMID: 11923214
    8. mutations in DLL3 cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis PMID: 12746394
    9. no novel or previously described mutations are present in our cohort, indicating that DLL3 mutations may not be a major cause of congenital scoliosis. PMID: 15717203
    10. The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity PMID: 18676613

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  • 相關疾病：
    Spondylocostal dysostosis 1, autosomal recessive (SCDO1)
  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2909

    OMIM: 277300

    KEGG: hsa:10683

    STRING: 9606.ENSP00000205143

    UniGene: Hs.127792