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DLL3 Recombinant Monoclonal Antibody

  • 中文名稱：
    DLL3重組抗體
  • 貨號：
    CSB-RA882142A1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Untransfected HEK293 cells surface (green line) and transfected Human DLL3 HEK293 stable cells surface (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2μl/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry.
    • The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
      Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP3536MOV) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC50 is 1.625-2.702 ng/mL.
    • The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
      Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP882142HU) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC50 is 1.102-1.707 ng/mL.
    • The purity of DLL3 was greater than 95% as determined by SEC-HPLC
  • 其他：

產品詳情

  • 產品描述：
    DLL3重組單克隆抗體（CSB-RA882142A1HU）是針對Delta樣配體3（DLL3）靶點開發(fā)的高特異性科研用抗體。DLL3作為Notch信號通路的關鍵調控分子，在細胞分化、組織發(fā)育及腫瘤發(fā)生中發(fā)揮重要作用，尤其在神經內分泌腫瘤和小細胞肺癌等疾病中呈現異常表達特征。本產品采用重組表達技術制備，經ELISA和流式細胞術（FC）嚴格驗證，在FC應用中表現出優(yōu)異的靈敏度和重復性，推薦使用稀釋比例為1:50-1:200，可精準識別天然構象的DLL3蛋白。其均一的單克隆特性確保了實驗數據的穩(wěn)定性和可重復性，適用于細胞表面蛋白定量分析、腫瘤細胞亞群分選、信號通路調控機制研究等領域?？蒲腥藛T可通過該抗體開展DLL3相關分子機制研究、體外藥物靶點篩選及腫瘤標志物檢測等實驗，為腫瘤生物學研究和抗腫瘤藥物開發(fā)提供可靠工具。本品嚴格遵循質量控制標準，適用于體外實驗體系，不涉及活體診斷或治療用途。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3), DLL3
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human DLL3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    7B7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
  • 基因功能參考文獻：
    1. these results reveal that DLL3 is expressed in tumor specimens from most patients with small cell lung cancer PMID: 29290251
    2. Results indicated that DLL3 expression was silenced in hepatocellular carcinoma (HCC) cells by DNA methylation and was more readily affected by histone acetylation than histone methylation (H3K9me2 or H3K27me3). PMID: 29512761
    3. our results indicated epidermal growth factor-like domain multiple 7 protein participates in growth hormone-secreting pituitary adenoma proliferation and invasion regulation via Notch2/DLL3 signaling pathway. These findings raised the possibility that epidermal growth factor-like domain multiple 7 protein might serve as a useful biomarker to assess growth hormone-secreting pituitary adenoma invasion and prognosis PMID: 28705113
    4. The Dll3 was rarely detectable in the para-carcinoma tissues, but positive in 82.1% of non-small cell cancer tissues. PMID: 28007595
    5. Both global haplotype and individual haplotype analyses showed that the haplotypes of SNP1/SNP2/SNP3/SNP4/SNP5 did not correlate with the disease (P >0.05). Together, these data suggest that genetic variants of the DLL3 gene are not associated with CS in the Chinese Han population. PMID: 27472720
    6. DLL3 was silenced by methylation in human human hepatocellular carcinoma and it negatively regulates the growth of human hepatocellular carcinoma cells. PMID: 23337976
    7. We suggest that the three human DLL3 mutations associated with spondylocostal dysplasia are also functionally equivalent to the Dll3(neo) null allele in mice. PMID: 11923214
    8. mutations in DLL3 cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis PMID: 12746394
    9. no novel or previously described mutations are present in our cohort, indicating that DLL3 mutations may not be a major cause of congenital scoliosis. PMID: 15717203
    10. The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity PMID: 18676613

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  • 相關疾?。?/div>
    Spondylocostal dysostosis 1, autosomal recessive (SCDO1)
  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 數據庫鏈接：

    HGNC: 2909

    OMIM: 277300

    KEGG: hsa:10683

    STRING: 9606.ENSP00000205143

    UniGene: Hs.127792