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  4. Human Interleukin-1 family member 10(IL1F10) ELISA kit

Human Interleukin-1 family member 10(IL1F10) ELISA kit

  • 中文名稱：
    人白介素1家族成員10(IL1F10)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL011615HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人白介素1家族成員10(IL1F10)酶聯(lián)免疫試劑盒（CSB-EL011615HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IL1F10含量。IL1F10，又稱IL-38，是白細胞介素1家族的一員，參與調節(jié)適應性及先天免疫反應。其研究背景涉及免疫調節(jié)，通過影響細胞因子產生發(fā)揮作用，單獨不誘導細胞因子產生，但在免疫反應中發(fā)揮調節(jié)作用。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，適用于基礎科研中探索IL1F10在炎癥相關疾病模型中的作用機制、評估實驗動物或細胞模型的蛋白表達動態(tài)變化，以及篩選調控該因子的藥物或化合物?？蒲腥藛T可通過本產品分析不同處理條件下生物樣本（如炎癥模型血清、腫瘤組織勻漿或免疫細胞培養(yǎng)上清）中IL1F10的表達水平，為免疫調節(jié)研究及疾病機理探索提供可靠數據支持。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    family of interleukin 1-theta ELISA Kit; FIL1 theta ELISA Kit; FIL1T ELISA Kit; FKSG75 ELISA Kit; IL 38 ELISA Kit; IL-1 theta ELISA Kit; IL-1F10 (canonical form IL-1F10a) ELISA Kit; IL-1F10 ELISA Kit; IL-1HY2 ELISA Kit; IL1 theta ELISA Kit; IL1F10 ELISA Kit; IL1FA_HUMAN ELISA Kit; IL1HY2 ELISA Kit; Interleukin 1 family member 10 (theta) ELISA Kit; Interleukin 1 receptor antagonist FKSG75 ELISA Kit; Interleukin 1 receptor antagonist homolog 2 ELISA Kit; Interleukin 1 receptor antagonist like FIL1 theta ELISA Kit; Interleukin-1 family member 10 ELISA Kit; Interleukin-1 HY2 ELISA Kit; Interleukin-1 theta ELISA Kit; interleukin-38 ELISA Kit
  • 縮寫：
    IL1F10
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.81 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human IL1F10 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %97
    Range %92-104
    1:2Average %84
    Range %80-88
    1:4Average %105
    Range %100-113
    1:8Average %95
    Range %90-100
  • 回收率：
    The recovery of human IL1F10 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8880-92
    EDTA plasma (n=4)9490-99
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1OD2AverageCorrected
    20002.070 2.217 2.144 2.044
    10001.393 1.321 1.357 1.257
    5000.756 0.809 0.783 0.683
    2500.421 0.445 0.433 0.333
    1250.267 0.254 0.261 0.161
    62.50.196 0.183 0.190 0.090
    31.250.151 0.154 0.153 0.053
    00.103 0.096 0.100
  • 數據處理：
  • 貨期：
    3-5 working days

引用文獻

產品評價

靶點詳情

  • 功能：
    Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.
  • 基因功能參考文獻：
    1. The serum level of IL-38 in the children in the acute phase of Kawasaki disease was significantly lower than that in the healthy control group PMID: 30022755
    2. IL-38 may play an important role in acute and/or chronic inflammation in anticancer drug-induced lung injury and acute exacerbation of idiopathic pulmonary fibrosis. PMID: 28942884
    3. IL-38 may exert its anti-inflammatory effects by decreasing the production of proinflammatory cytokines by macrophages and synovial fibroblasts. PMID: 28288964
    4. this clinical study demonstrates the elevation of anti-inflammatory cytokine IL-38 and the decrement of CD4+CD25highFoxP3+ and CD4+CD25highCD127- Treg in childhood asthma. The negative correlation of IL-38 and Treg lymphocytes may imply a negative feedback of the two anti-inflammatory factors in asthma. PMID: 27438823
    5. this study shows that in vivo expression of human IL-38 in mice has hepatoprotective effects against Con A-induced liver injury by inhibition of inflammatory cytokine production PMID: 27723569
    6. Higher serum IL-38 levels before treatment indicate a greater probability of viral response to telbivudine treatment in chronic hepatitis B. PMID: 27182162
    7. results indicate that circulating IL-38 is a potentially novel biomarker for patients with ST-segment elevation myocardial infarction PMID: 26819499
    8. Data suggest that IL-38 may be protective in SLE. A strong association between IL-38 and SLE severity suggests that IL-38 expression is driven by processes linked to SLE pathogenesis. PMID: 26314375
    9. rs6759676, closest gene locus IL1F10 is associated with increased circulating levels of IL-1 receptor antagonist, a protective factor in development of insulin resistance. PMID: 24969107
    10. The IL1A locus was strongly associated with alkylosing spondyloarthritis phenotype, whereas IL1F10 was associated with non-alkylosing spondyloarthritis. PMID: 22312160
    11. These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R] PMID: 22315422

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  • 亞細胞定位：
    Cytoplasm. Secreted.
  • 蛋白家族：
    IL-1 family
  • 組織特異性：
    Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.
  • 數據庫鏈接：

    HGNC: 15552

    OMIM: 615296

    KEGG: hsa:84639

    STRING: 9606.ENSP00000341794

    UniGene: Hs.306974