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IL1F10 Monoclonal Antibody

  • 中文名稱(chēng)：
    IL1F10鼠單克隆抗體
  • 貨號(hào)：
    CSB-MA8378691A0m
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Immunohistochemical of paraffin-embedded Human Colon cancer tissue using CSB-MA8378691A0m at dilution of 1:200.
    • Immunohistochemical of paraffin-embedded Human live cancer tissue using CSB-MA8378691A0m at dilution of 1:200.
    • Immunohistochemical of paraffin-embedded Human spleen tissue using CSB-MA8378691A0m at dilution of 1:200.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    IL1F10單克隆抗體（CUSABIO貨號(hào)：CSB-MA8378691A0m）是針對(duì)白細(xì)胞介素1家族成員IL-1F10研發(fā)的高特異性科研試劑，適用于人類(lèi)樣本的ELISA檢測(cè)及免疫組化實(shí)驗(yàn)。IL-1F10作為新型細(xì)胞因子，在調(diào)節(jié)炎癥反應(yīng)、免疫應(yīng)答及組織修復(fù)等過(guò)程中發(fā)揮重要作用，其表達(dá)水平與多種病理生理過(guò)程相關(guān)，是免疫調(diào)控機(jī)制研究的關(guān)鍵靶點(diǎn)之一。本產(chǎn)品采用雜交瘤技術(shù)制備，經(jīng)嚴(yán)格驗(yàn)證可特異性識(shí)別天然構(gòu)象的IL-1F10蛋白，適用于精準(zhǔn)檢測(cè)體外培養(yǎng)細(xì)胞、組織切片等樣本中的目標(biāo)蛋白定位與表達(dá)量分析?？蒲腥藛T可通過(guò)該抗體在炎癥性疾病機(jī)制研究、藥物靶點(diǎn)篩選及信號(hào)通路探索等方向開(kāi)展實(shí)驗(yàn)，尤其在探索IL-1F10與其他細(xì)胞因子相互作用、基因表達(dá)調(diào)控網(wǎng)絡(luò)等領(lǐng)域具有重要應(yīng)用價(jià)值。該產(chǎn)品提供即用型穩(wěn)定配方，實(shí)驗(yàn)重復(fù)性好，適用于多種蛋白檢測(cè)平臺(tái)，為免疫學(xué)、分子生物學(xué)及轉(zhuǎn)化醫(yī)學(xué)研究提供可靠工具。
  • 產(chǎn)品名稱(chēng)：
    mouse anti-Homo sapiens (Human) IL1F10 monoclonal antibody
  • Uniprot No.：
  • 基因名：
    IL1F10
  • 別名：
    family of interleukin 1-theta antibody; FIL1 theta antibody; FIL1T antibody; FKSG75 antibody; IL 38 antibody; IL-1 theta antibody; IL-1F10 (canonical form IL-1F10a) antibody; IL-1F10 antibody; IL-1HY2 antibody; IL1 theta antibody; IL1F10 antibody; IL1FA_HUMAN antibody; IL1HY2 antibody; Interleukin 1 family member 10 (theta) antibody; Interleukin 1 receptor antagonist FKSG75 antibody; Interleukin 1 receptor antagonist homolog 2 antibody; Interleukin 1 receptor antagonist like FIL1 theta antibody; Interleukin-1 family member 10 antibody; Interleukin-1 HY2 antibody; Interleukin-1 theta antibody; interleukin-38 antibody
  • 宿主：
    mouse
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human IL1F10 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    monoclonal
  • 抗體亞型：
    IgG1
  • 純化方式：
    >95%,protein G purifed
  • 克隆號(hào)：
    2A2B3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.
  • 基因功能參考文獻(xiàn)：
    1. The serum level of IL-38 in the children in the acute phase of Kawasaki disease was significantly lower than that in the healthy control group PMID: 30022755
    2. IL-38 may play an important role in acute and/or chronic inflammation in anticancer drug-induced lung injury and acute exacerbation of idiopathic pulmonary fibrosis. PMID: 28942884
    3. IL-38 may exert its anti-inflammatory effects by decreasing the production of proinflammatory cytokines by macrophages and synovial fibroblasts. PMID: 28288964
    4. this clinical study demonstrates the elevation of anti-inflammatory cytokine IL-38 and the decrement of CD4+CD25highFoxP3+ and CD4+CD25highCD127- Treg in childhood asthma. The negative correlation of IL-38 and Treg lymphocytes may imply a negative feedback of the two anti-inflammatory factors in asthma. PMID: 27438823
    5. this study shows that in vivo expression of human IL-38 in mice has hepatoprotective effects against Con A-induced liver injury by inhibition of inflammatory cytokine production PMID: 27723569
    6. Higher serum IL-38 levels before treatment indicate a greater probability of viral response to telbivudine treatment in chronic hepatitis B. PMID: 27182162
    7. results indicate that circulating IL-38 is a potentially novel biomarker for patients with ST-segment elevation myocardial infarction PMID: 26819499
    8. Data suggest that IL-38 may be protective in SLE. A strong association between IL-38 and SLE severity suggests that IL-38 expression is driven by processes linked to SLE pathogenesis. PMID: 26314375
    9. rs6759676, closest gene locus IL1F10 is associated with increased circulating levels of IL-1 receptor antagonist, a protective factor in development of insulin resistance. PMID: 24969107
    10. The IL1A locus was strongly associated with alkylosing spondyloarthritis phenotype, whereas IL1F10 was associated with non-alkylosing spondyloarthritis. PMID: 22312160
    11. These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R] PMID: 22315422

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  • 亞細(xì)胞定位：
    Cytoplasm. Secreted.
  • 蛋白家族：
    IL-1 family
  • 組織特異性：
    Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 15552

    OMIM: 615296

    KEGG: hsa:84639

    STRING: 9606.ENSP00000341794

    UniGene: Hs.306974