Human Matrin-3(MATR3) ELISA kit
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中文名稱:人基質(zhì)蛋白-3(MATR3)酶聯(lián)免疫試劑盒
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貨號:CSB-EL013525HU
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規(guī)格:96T/48T
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價格:¥3600/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:人基質(zhì)蛋白-3(MATR3)酶聯(lián)免疫試劑盒(CSB-EL013525HU)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿,組織勻漿、細胞裂解物樣本中的MATR3含量。MATR3是一個值得關(guān)注的靶點。它在細胞生理活動中有重要作用。目前研究聚焦于其在疾病發(fā)生發(fā)展中的機制,如參與調(diào)節(jié)基因表達、信號傳導(dǎo)等過程,對其深入研究有助于揭示相關(guān)疾病發(fā)病機理,為開發(fā)針對性治療策略提供依據(jù)。試劑盒檢測范圍為23.5 pg/mL-1500 pg/mL,適用于基礎(chǔ)科研領(lǐng)域,如探究MATR3在疾病模型中的表達動態(tài)、細胞應(yīng)激條件下的調(diào)控機制,或結(jié)合多組學(xué)分析揭示其在RNA代謝相關(guān)通路中的分子功能。試劑盒兼容多種生物樣本類型,可滿足體外培養(yǎng)細胞、動物組織及體液樣本的檢測需求,操作簡便且重復(fù)性良好,為分子生物學(xué)、細胞生物學(xué)及疾病機制研究提供可靠工具。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名:ALS21 ELISA Kit; KIAA0723 ELISA Kit; Matr3 ELISA Kit; MATR3_HUMAN ELISA Kit; Matrin-3 ELISA Kit; Matrin3 ELISA Kit; MPD2 ELISA Kit; VCPDM ELISA Kit; Vocal cord and pharyngeal weakness with distal myopathy ELISA Kit
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縮寫:MATR3
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Uniprot No.:
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種屬:Homo sapiens (Human)
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樣本類型:serum, plasma,tissue homogenates, cell lysates
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檢測范圍:23.5 pg/mL-1500 pg/mL
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靈敏度:5.8 pg/mL
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反應(yīng)時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領(lǐng)域:Epigenetics and Nuclear Signaling
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測定原理:quantitative
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測定方法:Sandwich
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精密度:
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
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線性度:
To assess the linearity of the assay, samples were spiked with high concentrations of human MATR3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
Sample
Serum(n=4)
1:1
Average %
92
Range %
85-99
1:2
Average %
96
Range %
91-100
1:4
Average %
91
Range %
84-97
1:8
Average %
93
Range %
86-98
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回收率:
The recovery of human MATR3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample Type
Average % Recovery
Range
Serum (n=5)
92
87-98
EDTA plasma (n=4)
97
91-103
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標準曲線:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
pg/ml
OD1
OD2
Average
Corrected
1500
2.724
2.634
2.679
2.555
750
2.055
2.167
2.111
1.987
375
1.264
1.328
1.296
1.172
187.5
0.736
0.729
0.733
0.609
94
0.371
0.381
0.376
0.252
47
0.243
0.253
0.248
0.124
23.5
0.175
0.184
0.180
0.056
0
0.123
0.125
0.124
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數(shù)據(jù)處理:
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貨期:3-5 working days
相關(guān)產(chǎn)品
靶點詳情
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功能:May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins.
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基因功能參考文獻:
- Depletion of SAFB1 reduced FUS's localization to chromatin-bound fraction and splicing activity, suggesting SAFB1 could tether FUS to chromatin compartment thorough N-terminal DNA-binding motif. Moreover, FUS interacts with another nuclear matrix-associated protein, Matrin3. PMID: 27731383
- Using a novel RNA pulldown approach that utilized endogenous S1-tagged PINCR (a p53-regulated long noncoding RNA), the authors show that PINCR associates with the enhancer region of these genes by binding to RNA-binding protein Matrin 3 that, in turn, associates with p53. PMID: 28580901
- Matrin3 physically interacts with intronic pyrimidine-rich sequences and controls alternative splicing. PMID: 28695676
- It may not be a common genetic factor in Chinese amyotrophic lateral sclerosis patients. PMID: 26708275
- Its mutations strengthens the role of RNA metabolism in amyotrophic lateral sclerosis etiology. PMID: 26493020
- A missense mutation in MATR3 was identified in myopathy patients undergoing a needle electromyography. PMID: 26899464
- Our findings indicate that mutations in Matrin 3 that are associated with ALS and myopathy do not dramatically alter the normal localization of the protein or readily induce inclusion formation. PMID: 26528920
- Three-dimensional mapping of the lamin A-matrin-3 interface showed that the LMNA truncating mutation Delta303, which lacks the matrin-3 binding domain, was associated with an increased distance between lamin A and matrin-3. PMID: 25948554
- Suppressing Matrin 3 powers a heightened and broader ZAP restriction of HIV-1 gene expression. PMID: 26129669
- MATR3 mutation is identified to be a possible cause of amyotrophic lateral sclerosis. PMID: 25771394
- No mutations were identified, indicating that MATR3 mutations are not a common cause of Amyotrophic lateral sclerosis in Australian familial cases with predominately European ancestry PMID: 25523636
- MATR3 gene disruption is associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus. PMID: 25574029
- Mutations in MATR3 are rare in French familial ALS and ALS with FTLD patients. PMID: 25158920
- This study shows a high risk of abnormal respiratory function with progressive worsening in MATR3 myopathy. PMID: 25677933
- Nuclear matrix protein Matrin3 regulates alternative splicing and forms overlapping regulatory networks with PTB. PMID: 25599992
- the pY RNA1-s2/Matr3 interaction could play a role in vision PMID: 24558381
- Sixteen patients from 6 families with late onset distal myopathy associated with the p.S85C MATR3 mutation were characterized. PMID: 25154462
- This study identified mutations in MATR3 in ALS kindreds. also observed MATR3 pathology in ALS-affected spinal cords with and without MATR3 mutations. PMID: 24686783
- Data suggest that the cellular level of MATR3, known to be highly regulated, modulates the stability of a group of gene transcripts. PMID: 21858232
- Rev needs MATR3 to promote the cytoplasmic accumulation and translation of unspliced RRE-containing mRNA. PMID: 21771348
- MATR3 binds viral RNA and is required for the Rev/RRE mediated nuclear export of unspliced HIV-1 RNAs. PMID: 21771346
- Matrin 3 binds Rev RNA to stabilize HIV-1 transcripts leading to increased cytoplasmic expression. PMID: 21771347
- MATR3 to be a novel ATM target in response to DNA damage. PMID: 20421735
- matrin 3 plays a significant role in controlling cell growth and proliferation PMID: 21182838
- study of the association of matr3 with chromosome territories and identification of potential interacting proteins PMID: 19562669
- Data show that the nuclear matrix protein matrin 3, cytoskeletal motor protein HMP, and the circadian clock protein lark were significantly decreased in fetal Down syndrome brain. PMID: 12469345
- These results suggest that the functions of matrin 3 could be regulated by both Ca(2+)-dependent interaction with calmodulin and caspase-mediated cleavage. PMID: 17658460
- the spatial proximities among a constellation of functionally related sites that are found within euchromatic regions of the cell nucleus including: HP1gamma, RNA polymerase II, matrin 3, and SAF-A sites PMID: 18618731
- nonconservative S85C missense mutation in vocal cord and pharyngeal weakness with distal myopathy PMID: 19344878
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相關(guān)疾?。?/div>Amyotrophic lateral sclerosis 21 (ALS21)亞細胞定位:Nucleus matrix.數(shù)據(jù)庫鏈接:
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