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  4. Human Ninjurin-1(NINJ1) ELISA kit

Human Ninjurin-1(NINJ1) ELISA kit

  • 中文名稱：
    人神經(jīng)損傷誘導(dǎo)蛋白-1(NINJ1)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL015808HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人神經(jīng)損傷誘導(dǎo)蛋白-1(NINJ1)酶聯(lián)免疫試劑盒（CSB-EL015808HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的NINJ1含量。試劑盒檢測范圍為25 pg/mL-1600 pg/mL，其寬泛的樣本兼容性使其適用于體外培養(yǎng)細(xì)胞模型、動物組織樣本及生物體液中的NINJ1動態(tài)監(jiān)測，可用于神經(jīng)退行性疾病模型構(gòu)建、藥物干預(yù)效果評估、神經(jīng)再生機制研究等基礎(chǔ)科研領(lǐng)域，為探索阿爾茨海默病、多發(fā)性硬化癥等疾病的生物標(biāo)志物提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    NINJ1; Ninjurin-1; Nerve injury-induced protein 1
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    25 pg/mL-1600 pg/mL
  • 靈敏度：
    6.25 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human NINJ1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 105
    Range % 94-109
    1:2 Average % 98
    Range % 90-102
    1:4 Average % 88
    Range % 81-91
    1:8 Average % 107
    Range % 98-111
  • 回收率：
    The recovery of human NINJ1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 94 90-98
    EDTA plasma (n=4) 104 94-107
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    1600 2.165 2.243 2.204 2.060
    800 1.718 1.765 1.742 1.598
    400 1.042 1.018 1.030 0.886
    200 0.587 0.579 0.583 0.439
    100 0.328 0.334 0.331 0.187
    50 0.242 0.255 0.249 0.105
    25 0.186 0.194 0.190 0.046
    0 0.146 0.142 0.144 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Homophilic transmembrane adhesion molecule involved in various processes such as inflammation, cell death, axonal growth, cell chemotaxis and angiogenesis. Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM). Involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells. Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding. Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions. Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation; directly binds LPS. Acts as a mediator of both programmed and necrotic cell death. Plays a key role in the induction of plasma membrane rupture during programmed and necrotic cell death: oligomerizes in response to death stimuli to mediate plasma membrane rupture (cytolysis), leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response. Plays a role in nerve regeneration by promoting maturation of Schwann cells. Acts as a regulator of angiogenesis. Promotes the formation of new vessels by mediating the interaction between capillary pericyte cells and endothelial cells. Promotes osteoclasts development by enhancing the survival of prefusion osteoclasts. Also involved in striated muscle growth and differentiation.; Secreted form generated by cleavage, which has chemotactic activity. Acts as an anti-inflammatory mediator by promoting monocyte recruitment, thereby ameliorating atherosclerosis.
  • 基因功能參考文獻(xiàn)：
    1. Data show that Ninj1 assembles into a homomeric protein complex and that N-glycosylation is a prerequisite for Ninj1 homomer assembly. PMID: 28067406
    2. Ninj1 suppresses migration, invasion and metastasis of lung cancer via inhibition of the IL-6 signaling pathway in vitro and in vivo. PMID: 26815582
    3. High ninjurin 1 expression is associated with Prostate Cancer. PMID: 28373430
    4. Ninj1 expression was detected in both HSMCs and HUVECs, and was higher in the former. Ninj1 expression was enhanced by hypoxia in HUVECs. PMID: 25766274
    5. Ninj1 modulates TLR4 signaling, which itself plays a major role in systemic inflammatory response syndrome and sepsis. PMID: 25860173
    6. The NINJ1 gene polymorphism plays an important role in nerve degeneration in leprosy patients. PMID: 22326538
    7. Data show an important cell-specific role for Ninjurin-1 in the transmigration of inflammatory APCs across the BBB. PMID: 22162058
    8. Ninjurin1 is able to induce the senescence program. Ninjurin1 may be involved in the regulation of cellular senescence in the liver during carcinogenesis. PMID: 15464245
    9. Our data suggests that Ninjurin 1 asp110ala SNP could be a valuable genetic marker of nerve damage in leprosy. PMID: 17825431

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  • 亞細(xì)胞定位：
    [Ninjurin-1]: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptic cell membrane; Multi-pass membrane protein.; [Secreted ninjurin-1]: Secreted.
  • 蛋白家族：
    Ninjurin family
  • 組織特異性：
    Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7824

    OMIM: 602062

    KEGG: hsa:4814

    STRING: 9606.ENSP00000364595

    UniGene: Hs.494457