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  4. Human left-right determination factor 2(LEFTY2) ELISA Kit

Human left-right determination factor 2(LEFTY2) ELISA Kit

  • 中文名稱：
    人左右不對(duì)稱發(fā)育因子2(LEFTY2)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E13590h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人左右不對(duì)稱發(fā)育因子2(LEFTY2)酶聯(lián)免疫試劑盒（CSB-E13590h）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿樣本中的LEFTY2含量。試劑盒檢測(cè)范圍為7.8 pg/mL-500 pg/mL，該產(chǎn)品適用于基礎(chǔ)科研領(lǐng)域，例如探究LEFTY2在胚胎發(fā)育異常、纖維化疾病或腫瘤發(fā)生發(fā)展中的分子機(jī)制，也可用于評(píng)估細(xì)胞模型或動(dòng)物模型中LEFTY2的表達(dá)水平變化。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書。
  • 別名：
    EBAF ELISA Kit; Endometrial bleeding associated factor (left right determination factor A transforming growth factor beta superfamily) ELISA Kit; Endometrial bleeding associated factor ELISA Kit; Endometrial bleeding-associated factor ELISA Kit; Left right determination factor 2 ELISA Kit; Left right determination factor A ELISA Kit; Left-right determination factor 2 ELISA Kit; Left-right determination factor A ELISA Kit; LEFTA ELISA Kit; LEFTY 2 ELISA Kit; LEFTY2 ELISA Kit; LEFTYA ELISA Kit; LFTY2 transforming growth factor; beta -4 ELISA Kit; LFTY2; mouse; homolog of ELISA Kit; LFTY2_HUMAN ELISA Kit; MGC46222 ELISA Kit; Protein lefty 2 ELISA Kit; Protein lefty A ELISA Kit; Protein lefty-2 ELISA Kit; Protein lefty-A ELISA Kit; Protein lefty2 ELISA Kit; PSEC0024 ELISA Kit; TGF beta 4 ELISA Kit; TGF-beta-4 ELISA Kit; TGFB4 ELISA Kit; Transforming growth factor beta 4 ELISA Kit; Transforming growth factor beta-4 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma
  • 檢測(cè)范圍：
    7.8 pg/mL-500 pg/mL
  • 靈敏度：
    1.95 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Cancer
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human LEFTY2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:100 Average % 91
    Range % 86-95
    1:200 Average % 102
    Range % 97-107
    1:400 Average % 91
    Range % 85-97
    1:800 Average % 97
    Range % 91-103
  • 回收率：
    The recovery of human LEFTY2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 95 89-98
    EDTA plasma (n=4) 97 90-100
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    500 2.811 2.836 2.824 2.744
    250 2.038 2.000 2.019 1.939
    125 1.331 1.368 1.350 1.270
    62.5 0.804 0.752 0.778 0.698
    31.2 0.473 0.498 0.486 0.406
    15.6 0.278 0.281 0.280 0.200
    7.8 0.173 0.169 0.171 0.091
    0 0.079 0.081 0.080 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
  • 基因功能參考文獻(xiàn)：
    1. functional role of LEFTY during progesterone therapy for endometrial carcinoma PMID: 29268772
    2. LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage. PMID: 27404958
    3. LEFTY2 down-regulates MKi67 expression and FAK activity, up-regulates miR-200a and E-cadherin, and is thus a powerful negative regulator of endometrial cell proliferation and migration. PMID: 27497669
    4. LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1. PMID: 27606670
    5. Lefty A may account for the tumor suppressive activity of human adult stem cells. PMID: 22469982
    6. Findings suggest that Lefty2 is negatively modulated by miR-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification. PMID: 21266536
    7. Findings show that during embryonic development, EBAF/LEFTY B plays important roles in decidualization and embryo implantation. PMID: 21401636
    8. findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression PMID: 9230066
    9. may provide a crucial signal for endometrial breakdown and bleeding by triggering expression of several matrix metalloproteinases PMID: 12215426
    10. nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells PMID: 15308665
    11. Addition of recombinant LEFTY-A to explants induced MMP-9 in most samples, a response prevented by ovarian steroids. PMID: 15536155
    12. LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation. PMID: 17038673

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  • 相關(guān)疾?。?/div>
    Left-right axis malformations (LRAM)
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 組織特異性：
    Mesenchymal cells of the endometrial stroma.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3122

    OMIM: 601877

    KEGG: hsa:7044

    STRING: 9606.ENSP00000355785

    UniGene: Hs.520187