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LEFTY2 Recombinant Monoclonal Antibody

  • 中文名稱：
    LEFTY2重組抗體
  • 貨號(hào)：
    CSB-RA171603A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Ntera-2 whole cell lysate, Hela whole cell lysate
      All lanes: LEFTY2 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 41, 38 kDa
      Observed band size: 36-45 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA171603A0HU LEFTY2 Recombinant Monoclonal Antibody是針對(duì)發(fā)育調(diào)控關(guān)鍵因子LEFTY2設(shè)計(jì)的高特異性檢測(cè)工具。該抗體靶向的LEFTY2蛋白屬于TGF-β超家族成員，在胚胎左右軸模式形成、組織器官發(fā)育及細(xì)胞命運(yùn)決定中發(fā)揮重要作用，同時(shí)參與腫瘤微環(huán)境調(diào)控等病理過(guò)程。經(jīng)嚴(yán)格驗(yàn)證，本重組單克隆抗體在Western Blot（WB）實(shí)驗(yàn)中表現(xiàn)出優(yōu)異的靶標(biāo)識(shí)別能力，推薦使用稀釋比為1:500-1:2000時(shí)能清晰檢測(cè)目標(biāo)蛋白表達(dá)，同時(shí)在ELISA平臺(tái)也具備可靠檢測(cè)性能，適用于多種哺乳動(dòng)物細(xì)胞裂解液或組織樣本的分析。研究人員可利用該抗體探索胚胎發(fā)育異常機(jī)制、干細(xì)胞分化調(diào)控以及腫瘤發(fā)生發(fā)展過(guò)程中LEFTY2介導(dǎo)的信號(hào)通路，特別是在研究器官不對(duì)稱發(fā)育、癌癥細(xì)胞侵襲轉(zhuǎn)移抑制、以及TGF-β超家族配體互作網(wǎng)絡(luò)等領(lǐng)域具有重要應(yīng)用價(jià)值。該產(chǎn)品采用重組表達(dá)技術(shù)保證批次穩(wěn)定性，為發(fā)育生物學(xué)、腫瘤學(xué)及細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)研究提供高質(zhì)量的實(shí)驗(yàn)保障。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Left-right determination factor 2 (Endometrial bleeding-associated factor) (Left-right determination factor A) (Protein lefty-2) (Protein lefty-A) (Transforming growth factor beta-4) (TGF-beta-4), LEFTY2, EBAF LEFTA LEFTYA TGFB4
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human LEFTY2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    10G2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
  • 基因功能參考文獻(xiàn)：
    1. functional role of LEFTY during progesterone therapy for endometrial carcinoma PMID: 29268772
    2. LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage. PMID: 27404958
    3. LEFTY2 down-regulates MKi67 expression and FAK activity, up-regulates miR-200a and E-cadherin, and is thus a powerful negative regulator of endometrial cell proliferation and migration. PMID: 27497669
    4. LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1. PMID: 27606670
    5. Lefty A may account for the tumor suppressive activity of human adult stem cells. PMID: 22469982
    6. Findings suggest that Lefty2 is negatively modulated by miR-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification. PMID: 21266536
    7. Findings show that during embryonic development, EBAF/LEFTY B plays important roles in decidualization and embryo implantation. PMID: 21401636
    8. findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression PMID: 9230066
    9. may provide a crucial signal for endometrial breakdown and bleeding by triggering expression of several matrix metalloproteinases PMID: 12215426
    10. nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells PMID: 15308665
    11. Addition of recombinant LEFTY-A to explants induced MMP-9 in most samples, a response prevented by ovarian steroids. PMID: 15536155
    12. LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation. PMID: 17038673

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  • 相關(guān)疾?。?/div>
    Left-right axis malformations (LRAM)
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 組織特異性：
    Mesenchymal cells of the endometrial stroma.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3122

    OMIM: 601877

    KEGG: hsa:7044

    STRING: 9606.ENSP00000355785

    UniGene: Hs.520187