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  4. Human thymus activation regulated chemokine,TARC ELISA Kit

Human thymus activation regulated chemokine,TARC ELISA Kit

  • 中文名稱：
    人胸腺活化調(diào)節(jié)趨化因子(TARC/CCL17)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E09257h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人胸腺活化調(diào)節(jié)趨化因子(TARC/CCL17)酶聯(lián)免疫試劑盒（CSB-E09257h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CCL17含量。CCL17，又稱胸腺和激活調(diào)節(jié)趨化因子（TARC），是一種與2型免疫反應(yīng)相關(guān)的趨化因子，位于人類16號染色體上。CCL17由胸腺和抗原呈遞細胞產(chǎn)生，通過與CCR4受體結(jié)合，招募Th2淋巴細胞，參與嗜酸性粒細胞相關(guān)疾病和某些T細胞淋巴瘤的轉(zhuǎn)運，同時與自身免疫性疾病和過敏性疾病有關(guān)。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL，靈敏度為3.9 pg/mL。該產(chǎn)品適用于基礎(chǔ)醫(yī)學研究領(lǐng)域，如探索過敏性疾?。ㄌ貞?yīng)性皮炎、過敏性鼻炎）、自身免疫性疾病（如類風濕性關(guān)節(jié)炎）的發(fā)病機制，或評估腫瘤微環(huán)境中免疫細胞趨化調(diào)控機制。試劑盒兼容多種生物樣本類型，支持科研人員通過血清/血漿檢測系統(tǒng)循環(huán)水平，或通過組織勻漿分析局部病灶中的表達差異，為體外實驗研究提供高效可靠的檢測工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    A-152E5.3 ELISA Kit; A152E53 ELISA Kit; ABCD 2 ELISA Kit; ABCD2 ELISA Kit; C-C motif chemokine 17 ELISA Kit; CC chemokine TARC ELISA Kit; CCL17 ELISA Kit; CCL17_HUMAN ELISA Kit; Chemokine CC Motif Ligand 17 ELISA Kit; MGC138271 ELISA Kit; MGC138273 ELISA Kit; SCYA17 ELISA Kit; Small Inducible Cytokine A17 ELISA Kit; Small Inducible Cytokine A17 Precursor ELISA Kit; Small Inducible Cytokine Subfamily A (Cys Cys) ELISA Kit; Small Inducible Cytokine Subfamily A (Cys Cys) Member 17 ELISA Kit; Small-inducible cytokine A17 ELISA Kit; T Cell Directed CC Chemokine ELISA Kit; Thymus and activation regulated chemokine ELISA Kit; Thymus and activation-regulated chemokine ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    15.6 pg/mL-1000 pg/mL
  • 靈敏度：
    3.9 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<10%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human TARC in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:5 Average % 106    
    Range % 101-115    
    1:10 Average % 104    
    Range % 102-108    
    1:20 Average % 87    
    Range % 84-93    
    1:40 Average % 94    
    Range % 90-97    
  • 回收率：
    The recovery of human TARC spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 96 90-101    
    EDTA plasma (n=4) 89 85-92    
                   
                   
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    pg/ml OD1 OD2 Average Corrected    
    1000 2.455 2.655 2.555 2.385    
    500 2.015 2.101 2.058 1.888    
    250 1.323 1.333 1.328 1.158    
    125 0.738 0.802 0.770 0.600    
    62.5 0.420 0.453 0.437 0.267    
    31.2 0.288 0.282 0.285 0.115    
    15.6 0.213 0.218 0.216 0.046    
    0 0.169 0.171 0.170 　    
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 最新研究進展：
        CCL17（也稱為TARC）是一種由多種細胞產(chǎn)生的蛋白質(zhì)，如巨噬細胞和淋巴細胞。它是一種趨化因子，可以吸引T細胞、樹突狀細胞等炎癥相關(guān)細胞的遷移。CCL17已被證明參與了多種疾病的發(fā)生和發(fā)展，如過敏性疾病、腫瘤、自身免疫性疾病等。CCL17的異常表達與這些疾病的病理生理過程密切相關(guān)，因此它也被認為是這些疾病的潛在治療靶點。
     
  • 功能：
    Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
  • 基因功能參考文獻：
    1. The frequency of the CC genotype in the TARC rs223828 SNP was higher in patients with intractable Graves disease than in patients with Graves disease in remission. PMID: 29848886
    2. The expression of CCL17 was decreased in nasal polyp (NP) epithelium compared to the epithelium of normal ethmoid sinus, whereas the expression of CCL22 was not decreased. E-cadherin was differentially distributed between the epithelium of normal ethmoid sinus and NP epithelium. EGFR was also decreased in NPs. PMID: 29746583
    3. TARC serum levels were elevated in 78% of sarcoidosis patients and correlated with disease severity. PMID: 29598931
    4. Serum TARC level may be a potent marker reflecting better response to IL-17A inhibitors for psoriasis treatment. PMID: 29655215
    5. This review presents key clinical studies of Multiple sclerosis together with experimental studies in animals that have demonstrated functional roles of CCR4, CCL17, and CCL22 in experimental autoimmune encephalomyelitis pathogenesis. [review] PMID: 29099057
    6. Taken together, our data showed a likely positive feedback mechanism of enhanced IL-6 production in ectopic milieu. The high levels of IL-6 in the peritoneal cavity stimulate the expression of CCL17 in endometrial stromal cells by activating JNK signal pathway, and then, CCL17 further induces CCR4 expression on macrophages, which eventually leads to an increase in IL-6 production via NF-kappaB activation. PMID: 28240436
    7. Data suggest that high levels of CCL17 and CCL22 in endometrium in women with endometriosis promote (1) recruitment of Tregs, (2) immunosuppression of Tregs, and (3) angiogenesis in endometrium. (Tregs = regulatory T cells) PMID: 28383711
    8. Serum TARC levels correlate well with indicators of systemic inflammation and of disease severity among patients with a drug eruption except SJS/TEN. Serum TARC may be a prognostic biomarker of severity of inflammation in drug eruptions. PMID: 28648978
    9. TARC production in HaCaT keratinocytes through the interaction between IL-22 and IL-22Ralpha facilitates T-cell migration in atopic dermatitis caused by house dust mites. PMID: 26914146
    10. TARC is a candidate biomarker for PTSD only in males. PMID: 28170001
    11. High CCL17 expression is associated with colon cancer cell migration. PMID: 28146427
    12. GM-CSF can mediate inflammation and pain by regulating IRF4-induced CCL17 production PMID: 27525438
    13. Based on the ADEPT study data set, we report that airway mucosal expression of CCL26 was a robust discriminator of type 2 inflammation from healthy nonatopic subjects. Furthermore, airway mucosal CCL26 expression was best identified by using a panel of clinical biomarkers, including Feno values, bEOS counts, and expression of 2 novel markers, sCCL17 and sCCL26 PMID: 28089872
    14. Low CCL17 expression is a potential independent adverse prognostic biomarker for recurrence and survival of patients with clear cell renal cell carcinoma after nephrectomy. PMID: 28178948
    15. IP-10 serum increase or TARC/IP-10 ratio decrease along with abnormal hepatic enzymatic alteration could signify early rejection of the transplanted liver. PMID: 28245475
    16. elevated pre-treatment levels of sGal-1, sCD163, sCD30 and TARC can be found in patients with classic Hodgkin lymphoma. However, only plasma TARC accurately reflects disease activity and correlates with clinical treatment response. PMID: 27610595
    17. levels elevated in rheumatoid arthritis synovial fluid, due to production by mononuclear cells, particularly CD1c classical dendritic cells PMID: 27250804
    18. Serum TARC levels are well correlated with blood eosinophil counts in patients with generalized drug eruptions, indicating that Th2-type immune reactions underlie TARC production. Serum TARC measurements also have potent diagnostic value for DIHS, with high sensitivity and specificity. PMID: 27497618
    19. Data suggest that Th1 (IFN-gamma-inducible protein-10 IP-10/CXCL10) and Th2 (thymus and activation regulated chemokine TARC/CCL17) and (macrophage derived chemokine MDC/CCL22) cooperatively play a role in the development of ankylosing spondylitis (AS). PMID: 26827189
    20. CCL17 positively regulates the tumorigenesis of hepatocellular carcinoma.Higher levels of intratumoral CCL17 expression are associated with poorer survival of hepatocellular carcinoma patients. PMID: 26781124
    21. CCL17 and CCL18 dermal expression is associated with leprosy polarity. PMID: 25412496
    22. The SNP rs223895 in TARC/CCL17 gene is associated with the susceptibility to Kawasaki disease. PMID: 26182268
    23. Serum CCL17 levels are associated with coronary artery disease and atherosclerosis severity independently of traditional cardiovascular risk factors. PMID: 25555269
    24. TARC was correlated with disease status and its monitoring may be able to predict PET positivity after alloSCT, thus potentially allowing an early immune manipulation. PMID: 25240818
    25. Serum levels of CCL17 were positively correlated with coronary artery disease. PMID: 25062565
    26. increased expression in the thymus of myasthenia gravis patients PMID: 24397961
    27. TARC and interleukin-31 may be biomarkers for adult atopic dermatitis PMID: 24984931
    28. Serum TARC is a promising biomarker for remission and can be used for accurately monitoring proactive treatment for long-term control. [revew] PMID: 24628072
    29. disease activity and response biomarker in alopecia areata PMID: 24102731
    30. High CXCL10 levels were detected in acutely infected children regardless of virus pathogen, whereas increased CCL17 production was RSV-specific PMID: 25013801
    31. Higher serum concentrations of CCL17 at baseline may be predictive of acute exacerbations in patients with chronic hypersensitivity pneumonitis PMID: 23705860
    32. might be potential marker of non-eosinophilic oesophagitis gastrointestinal food allergies PMID: 24698291
    33. Serum TARC may represent a suitable biomarker for monitoring of atopic dermatitis severity in daily practice. PMID: 25199679
    34. Although TARC and I-TAC may not directly regulate pruritus in atopic dermatitis patients, these chemokines are very sensitive disease markers of AD. PMID: 24104601
    35. we found that TARC is an easily measured biomarker that is associated with faster TTR, longer PFS, and possibly longer OS in a population of patients with HL who were treated with panobinostat. PMID: 23822537
    36. The serum TARC level is a very sensitive biomarker for monitoring the severity and treatment response in AD PMID: 25268342
    37. CCL17 is an antimicrobial protein with bacteriocidal activity against E. coli and S. aureus. PMID: 12949249
    38. An association between TARC/CCL17 polymorphisms, susceptibility of Kawasaki disease, and intravenous immunoglobulin responses in Kawasaki disease patients. PMID: 23942559
    39. Migration assays were performed to evaluate CCL17-induced colon cancer cell (HT-29) chemotaxis and RhoA protein levels were quantified. PMID: 24582560
    40. Ginseng inhibited TARC expression via blockade of NF-kappaB activation in HaCaT cells. PMID: 23454147
    41. CCL17-induced, CCR4-dependent release of CGRP by human airway epithelial cells represents a novel inflammatory pathway in patients with asthma and allergic disease. PMID: 23731651
    42. These data reveal an elevated serum concentration of Th2-attracting chemokines CCL22 and CCL17 in opsoclonus-myoclonus syndrome. PMID: 23340773
    43. Autistic children had significantly higher serum levels of TARC than healthy controls PMID: 23782855
    44. Serum CD163 and TARC as disease response biomarkers in classical Hodgkin lymphoma. PMID: 23224400
    45. Data suggest an important role for serum CCL17 level as biomarker of drug resistance/remission induction in Hodgkin lymphoma in response to various combined neoplastic agent protocols. PMID: 23225085
    46. increased expression in macrophages from asthmatic patients PMID: 22981793
    47. Data show that PD-1, PD-L1, PD-L2, CCL17, and CCL22 mRNA was identified in papillomas. PMID: 22322668
    48. Serum concentrations of TARC and CTACK were significantly higher in AD (atopic dermatitis) children than in healthy controls, and correlated with severity of symptoms. PMID: 22017510
    49. Baseline plasma thymus and activation-regulated chemokine levels correlate with classical Hodgkin's lymphoma tumor burden and serial levels correlate with response to treatment in patients with classical Hodgkin's lymphoma. PMID: 22058214
    50. PI16-positive Treg showed enhanced in vitro migration towards the inflammatory chemokines CCL17 and CCL20, suggesting they can migrate to sites of inflammation PMID: 22533972

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 組織特異性：
    Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10615

    OMIM: 601520

    KEGG: hsa:6361

    STRING: 9606.ENSP00000219244

    UniGene: Hs.546294