Mouse BMP-binding endothelial regulator protein(BMPER) ELISA kit
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中文名稱:小鼠BMP結(jié)合內(nèi)皮調(diào)節(jié)因子(BMPER)酶聯(lián)免疫試劑盒
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貨號:CSB-EL002747MO
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規(guī)格:96T/48T
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價格:¥3600/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:小鼠BMP結(jié)合內(nèi)皮調(diào)節(jié)因子(BMPER)酶聯(lián)免疫試劑盒(CSB-EL002747MO)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的BMPER含量。BMPER是一個靶點。其它在相關(guān)生理過程中可能發(fā)揮一定作用。研究機制上,或許參與調(diào)控骨形態(tài)發(fā)生蛋白信號通路等,影響細胞的生長、分化等過程,但目前關(guān)于它的詳細研究機制還需進一步深入探索以明確其具體作用。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL,廣泛應(yīng)用于基礎(chǔ)科研領(lǐng)域,例如通過檢測疾病模型動物(如血管異?;蚱鞴侔l(fā)育缺陷模型)中BMPER的表達動態(tài),探索其在病理生理中的作用機制,或用于體外細胞實驗中蛋白表達水平的定量評估,為信號通路研究、藥物靶點篩選及分子互作分析提供可靠工具。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名:Bmper ELISA kit; Cv2BMP-binding endothelial regulator protein ELISA kit; Bone morphogenetic protein-binding endothelial cell precursor-derived regulator ELISA kit; Protein crossveinless-2 ELISA kit; mCV2 ELISA kit
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縮寫:BMPER
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Uniprot No.:
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種屬:Mus musculus (Mouse)
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樣本類型:serum, plasma, tissue homogenates, cell lysates
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檢測范圍:31.25 pg/mL-2000 pg/mL
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靈敏度:7.81 pg/mL
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反應(yīng)時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領(lǐng)域:Cardiovascular
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測定原理:quantitative
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測定方法:Sandwich
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數(shù)據(jù)處理:
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貨期:3-5 working days
相關(guān)產(chǎn)品
靶點詳情
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功能:Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.
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基因功能參考文獻:
- BMPER contributes to the precise control of BMP activity within the aorta-gonad-mesonephros region, enabling the maturation of hematopoietic stem cells within a BMP-negative environment. PMID: 29093060
- CV2 binds directly to BMP10, as determined by co-immunoprecipitation, and inhibits BMP10 from initiating SMAD signaling, as determined by luciferase reporter gene assays. BMP10 and CV2 have important roles in coordinating cardiomyogenesis in progenitor cells. PMID: 28464239
- BMPER/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response. PMID: 28596374
- The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis. PMID: 25503991
- BMPER-induced BMP signaling promotes coronary artery remodeling. PMID: 24373957
- BMPER appears to play a role in regulating both vessel density and cardiac development PMID: 23200275
- BMPER expression is decreased following lung injury, which in turn impairs epithelial integrity, characterized by reduction of E-cadherin and epithelial leakage in vitro and in vivo. PMID: 23716395
- Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis. PMID: 22772758
- The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER. PMID: 22020334
- Bmper may play an important role in suppressing hepcidin production in hypotransferrinemic mice. PMID: 22144676
- BMP modulator BMPER is a new protective regulator of vascular inflammation that modulates leukocyte adhesion and migration in vitro and in vivo. PMID: 21900199
- BMPER is important in the regulation of BMP signaling and revascularization in the hypoxic retina. PMID: 21737784
- The data indicate a role for CV2 and Chd in the establishment of the vertebral morphogenetic field through the long-range relocalization of Chd/BMP complexes. PMID: 20807528
- Cv2 enhances pro-BMP activity of Tsg. PMID: 19914233
- Cv2 is a conserved, positive regulator of bone morphogenetic protein signaling. Its cysteine-rich domains acts as both positive and negative modulators of BMP signaling. PMID: 15188429
- crossveinless 2 has essential pro-Bmp functions for locally restricted signal enhancement in multiple aspects of mammalian organogenesis. PMID: 17035289
- The context-dependent functional relationship between Tsg and Cv2 during mouse development, is presented. PMID: 18644438
- Cv2 may specify cardiac mesodermal lineage through inhibition of BMP signaling at early stage of cardiogenesis. PMID: 18662983
- Development of the vertebral morphogenetic field is reported in the interactions of CV-2 and Twg. PMID: 18789316
- Study demonstrates that as molar concentrations of Bmper exceed Bmp4, Bmper dynamically switches from an activator to an inhibitor of Bmp4 signaling. PMID: 19221194
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亞細胞定位:Secreted.
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數(shù)據(jù)庫鏈接:
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