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  4. Mouse Cadherin-3(CDH3) ELISA kit

Mouse Cadherin-3(CDH3) ELISA kit

  • 中文名稱：
    小鼠鈣黏蛋白3(CDH3)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL005052MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠鈣黏蛋白3(CDH3)酶聯(lián)免疫試劑盒（CSB-EL005052MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CDH3含量。CDH3是一種重要靶點(diǎn)。其背景在于在多種生理與病理過程中發(fā)揮關(guān)鍵作用，尤其在腫瘤發(fā)生發(fā)展里常異常表達(dá)。研究機(jī)制方面，主要聚焦于其在細(xì)胞黏附、信號傳導(dǎo)等過程的作用，探索通過干預(yù)它來抑制腫瘤生長、轉(zhuǎn)移等的策略。試劑盒檢測范圍為78 pg/mL-5000 pg/mL，靈敏度為19.5 pg/mL。本試劑盒通過特異性抗體對實(shí)現(xiàn)高靈敏檢測，適用于小鼠模型中CDH3蛋白表達(dá)水平的動態(tài)監(jiān)測，可廣泛用于腫瘤生物學(xué)、胚胎發(fā)育或炎癥微環(huán)境等領(lǐng)域的基礎(chǔ)研究?？蒲腥藛T可通過深入探究CDH3在細(xì)胞遷移調(diào)控、上皮間質(zhì)轉(zhuǎn)化等分子機(jī)制中的作用，為疾病相關(guān)信號通路研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Cdh3; Cdhp; Cadherin-3; Placental cadherin; P-cadherin
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    78 pg/mL-5000 pg/mL
  • 靈敏度：
    19.5 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
  • 基因功能參考文獻(xiàn)：
    1. P-Cadherin is not required for maintenance of retinal stem cells in vivo. PMID: 28494434
    2. P-cadherin (CDH3) is highly dominant in both mouse and human retinal pigment epithelium in situ. The degree of dominance of P-cadherin is surprisingly large, with mouse Cdh3 and human CDH3 accounting for 82-85% and 92-93% of the total of the three cadherin mRNAs, respectively. PMID: 29338041
    3. P-cadherin is a direct PAX3-FOXO1A transcriptional target involved in Alveolar rhabdomyosarcoma aggressiveness. PMID: 22710718
    4. Loss of P-cadherin is associated with melanoma. PMID: 21445019
    5. UVB exposure resulted in the overexpression of the cytokines, tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and the adhesion molecule P-cadherin. PMID: 20212509
    6. Truncated P-cadherin promotes melanoma cell invasion and migration and therefore has an important role in the progression of malignant melanoma. PMID: 16919267
    7. P-cadherin is a newly defined transcriptional target gene of p63, with a crucial role in hair follicle morphogenesis as well as the apical ectodermal ridge during limb bud outgrowth in humans whereas it is not required for either in mice. PMID: 18199584

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:12560

    STRING: 10090.ENSMUSP00000079613

    UniGene: Mm.4658