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  4. Mouse Epidermal growth factor-like protein 7(EGFL7) ELISA kit

Mouse Epidermal growth factor-like protein 7(EGFL7) ELISA kit

  • 中文名稱：
    小鼠表皮生長因子樣蛋白7(EGFL7)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL007476MO
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠表皮生長因子樣蛋白7(EGFL7)酶聯(lián)免疫試劑盒（CSB-EL007476MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿,組織勻漿樣本中的EGFL7含量。EGFL7即表皮生長因子樣結構域蛋白7。它與血管生成、腫瘤發(fā)生發(fā)展等密切相關。研究機制上，它能調節(jié)內皮細胞的遷移、增殖和管腔形成，影響血管新生。其異常表達還參與腫瘤微環(huán)境改變，為腫瘤治療提供了潛在靶點。試劑盒檢測范圍為7.8 ng/mL-500 ng/mL，適用于基礎研究中EGFL7蛋白表達的動態(tài)監(jiān)測，例如血管生成機制探索、腫瘤微環(huán)境分析或心血管疾病模型中的分子水平評估，能夠為體外實驗、動物模型或組織樣本的定量分析提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Egfl7 ELISA kit; Megf7Epidermal growth factor-like protein 7 ELISA kit; EGF-like protein 7 ELISA kit; Multiple epidermal growth factor-like domains protein 7 ELISA kit; Multiple EGF-like domains protein 7 ELISA kit; NOTCH4-like protein ELISA kit; Vascular endothelial statin ELISA kit; VE-statin ELISA kit; Zneu1 ELISA kit
  • 縮寫：
    EGFL7
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma,tissue homogenates
  • 檢測范圍：
    7.8 ng/mL-500 ng/mL
  • 靈敏度：
    1.95 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Cardiovascular
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.
  • 基因功能參考文獻：
    1. EGFL7 reduces CNS inflammation in the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. PMID: 29483510
    2. Egfl7 is crucial for placental vascularization and embryonic growth. PMID: 28526753
    3. the angiogenic factor Egfl7 activates the Flt3/Flt3 ligand pathway and is a key molecular driver enforcing thymus progenitor generation and thereby directly links endothelial cell biology to the production of T cell-based adaptive immunity PMID: 28601636
    4. EGFL7 is required for VEGF upregulation of the Akt/Erk (1/2) pathway during angiogenesis. PMID: 24647208
    5. EGFL7 enhances EGFR-AKT signaling, epithelial-mesenchymal transition, and metastasis of gastric cancer cells. PMID: 24945379
    6. Egfl7 could be a HIF-1alpha responsive gene regulated by oxygen tension. PMID: 25539718
    7. Using the BPH/5 model of pre-eclampsia (PE), we show that the downregulation of Egfl7 in compromised placentas occurs prior to the onset of characteristic maternal signs of PE. PMID: 24751645
    8. egfl7 is initially expressed in all endothelial cells and then is progressively restricted to veins and to their neighbouring capillaries. PMID: 24595089
    9. EGFL7 is expressed in the bone microenvironment and has a role in promoting endothelial cell migration and tube-like structure formation through integrin-mediated pathways. PMID: 24909139
    10. Expression of Egfl7 in breast and lung carcinoma cells accelerates tumor growth and metastasis in immunocompetent mice but not in immunodeficient mice. PMID: 22037871
    11. Overexpression of endothelial Egfl7 is associated with impaired angiogenesis and altered Notch signaling PMID: 20947685
    12. the expression of the VE-statin/egfl7 gene in endothelial cells and the specific importance of ETS and GATA factors PMID: 20808444
    13. is the first identified inhibitor of mural cell migration specifically produced by endothelial cells. PMID: 14592969
    14. regulator that controls a specific and important step in vasculogenesis PMID: 15085134
    15. EGFL7 protein is localized to the endoplasmic reticulum and Golgi apparatus, suggesting that the protein is targeted for secretion PMID: 15162510
    16. The recombinant protein is pure as assessed by SDS-PAGE, immunoblot and mass spectrometry, and is biologically active as a repressor of human aortic smooth muscle cell migration induced by platelet-derived growth factor-BB. PMID: 16169248
    17. EGFL7 defines the optimal path of endothelial cells movement by assuring the correct positioning of each EC in a nascent sprout. PMID: 17626061
    18. EGFL7 provides a proper microenvironment for endothelial cell migration, thereby enabling accurate patterning. PMID: 18300411
    19. VE-statin/egfl7 produced by endothelial cells binds to the catalytic domains of enzymes of the LOX family in the vascular wall, thereby preventing the crosslink of tropoelastin molecules into mature elastin polymers and regulating vascular elastogenesis. PMID: 18497746
    20. Results provide the first evidence of a non-endothelial expression of EGFL7 and suggest distinctive roles for Egfl7 in vascular development and germ cell differentiation. PMID: 18556249
    21. demonstrate the regulation of angiogenesis by an endothelial miRNA, attribute previously described Egfl7 vascular phenotypes to miR-126, and document inadvertent miRNA dysregulation as a complication of knockout strategies PMID: 18987025
    22. Data identified neurons as a source of EGFL7 in the brain, suggesting that brain-derived EGFL7 acts as an endogenous antagonist of Notch signalling that regulates proliferation and differentiation of subventricular zone-derived adult NSCs. PMID: 19503073
    23. Egfl7 promotes metastasis of hepatocellular carcinoma (HCC) by enhancing cell motility through EGFR-dependent FAK phosphorylation. PMID: 19824075

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  • 亞細胞定位：
    Secreted, extracellular space.
  • 組織特異性：
    Expressed specifically by endothelial cells of the highly vascularized organs heart, lung and kidney.
  • 數(shù)據(jù)庫鏈接：