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  4. Mouse Tumor necrosis factor ligand superfamily member 4(TNFSF4) ELISA kit

Mouse Tumor necrosis factor ligand superfamily member 4(TNFSF4) ELISA kit

  • 中文名稱：
    小鼠腫瘤壞死因子配體超家族成員4(TNFSF4)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL023994MO
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠腫瘤壞死因子配體超家族成員4(TNFSF4)酶聯(lián)免疫試劑盒（CSB-EL023994MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的TNFSF4含量。TNFSF4是一個重要靶點。它是腫瘤壞死因子超家族成員，在免疫調(diào)節(jié)等生理過程中起關(guān)鍵作用。研究發(fā)現(xiàn)其異常表達與自身免疫疾病、腫瘤等多種疾病相關(guān)。目前圍繞其信號通路、與受體相互作用等機制研究，有望為相關(guān)疾病治療提供新方向。試劑盒檢測范圍為15.6pg/mL-1000pg/mL，適用于免疫調(diào)控機制研究、炎癥性疾病動物模型評估、腫瘤免疫微環(huán)境分析等科研場景，也可用于藥物開發(fā)過程中靶向TNFSF4通路的干預(yù)效果驗證。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Tnfsf4; Ox40l; Txgp1l; Tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; CD antigen CD252
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍：
    15.6pg/mL-1000pg/mL
  • 靈敏度：
    3.9 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Others
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
  • 基因功能參考文獻：
    1. these findings demonstrate the utility of soluble OX40 L and JAG1 to induce TCR-independent regulatory T-cells proliferation PMID: 28045060
    2. The OX40L expression is induced on the bronchiolar progenitors for the antiviral immunity during the infectious process. However, these defense-like host responses lead to more extensive infection with the influenza virus owing to the induced OX40L with alpha-2,6 sialic acid modification, which augments the interaction with the viral hemagglutinin. PMID: 26976612
    3. Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33 PMID: 26100084
    4. intestinal Th2 priming is initiated by an autocrine/paracrine acting CD4(+) Th cell-intrinsic IL-4 program that is controlled by DC OX40L, and not by NKT, gammadelta T, or ILC cells. PMID: 24781052
    5. a critical role of OX40L presented by the activated basophils to initiate Th2 responses in an allergic asthma model, implicating OX40-OX40L signaling as a potential therapeutic target in the treatment of allergic airway inflammation. PMID: 25839234
    6. The majority of transferred CD40L(-/-) T cells in Rag-1(-/-) B6 mice were differentiated to CD44(high). PMID: 24254032
    7. The need for additional immune suppression in the intestine reflects commensal microbe-driven T-cell activation through the accessory costimulation molecules ICOSL and OX40L in B7 deprived mice. PMID: 25002484
    8. we identify a previously unknown role for OX40L in steady-state bone homeostasis PMID: 24469824
    9. Data indicate that OX40L contributes to both the development of Th2 cells and secondary Th2 responses induced by KLH-pulsed CD8- cDCs in vivo. PMID: 24462862
    10. These results showed a critical role for OX40L- and Jagged1-induced cosignaling in GM-BMDC-induced Treg expansion. PMID: 23630352
    11. engagement of OX40L selectively suppresses Fyn-initiated signals required for MC degranulation and serves to limit immediate hypersensitivity PMID: 22564682
    12. Present findings suggest a role for the OX40L-derived immune response and epistatic genetic effect in immune-mediated pathogenesis of PAH. PMID: 22171643
    13. The vascular OX40/OX40L system plays an important role in the formation of vasa vasorum and subsequent atherosclerosis. PMID: 20584752
    14. our data provide an in vivo role for the OX40/OX40L system in the innate immune response during polymicrobial sepsis PMID: 20844189
    15. Tumor necrosis factor ligand OX40L-expressing Langerhans cells play a mandatory role in the induction of regulatory T cells in ultraviolet B immunosuppressed mice. PMID: 20400709
    16. Constitutive interaction of OX40 ligand with OX40 during immune regulation is linked to the development of autoimmune-like diseases in OX40L-transgenic mice. PMID: 12370402
    17. Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion. PMID: 12668647
    18. Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma. PMID: 12672051
    19. Engagement of OX40 by an OX40L:Ig fusion protein drives IFN-gamma production by CD4+ T cells and reduces eosinophilia and the burden of Cryptococcus neoformans in the lung. PMID: 12794142
    20. A null allele at OX40L completely prevents diabetes development in nonobese diabetic mice and strongly reduces its incidence in a T cell receptor transgenic model, while paradoxically sustaining the long-term progression to autoimmune destruction. PMID: 14662903
    21. OX40-OX40L interaction affects both regulatory and nonregulatory T cells by influencing suppression, susceptibility to suppression, and clonal expansion. PMID: 15004159
    22. OX40 and OX40L interactions form a late checkpoint in diabetes development and are realistic targets for therapeutic intervention. PMID: 15368274
    23. neonatal CD4+ CD3- cells up-regulate both CD30L and OX40L after adoptive transfer into an adult recipient PMID: 16920944
    24. OX40 ligand (OX40L) is required for optimal T helper (Th) type 2 cell priming and memory Th2 responses in vivo; dependence upon OX40L is predominantly due to the provision of signaling through OX40 rather than retrograde signaling dendritic cells. PMID: 17785785
    25. These results show a critical role for OX40L on DCs, via binding to OX40 on NKT cells and CD4+ T cells, in the induction of antitumor immunity in tumor-bearing mice. PMID: 17975668
    26. OX40 ligand (OX40L) is a critical in vivo mediator of TSLP-mediated Th2 responses. PMID: 18060034
    27. Th2 skewing is mediated by OX40L PMID: 18354165
    28. TNFSF4 gene is identified as a potential candidate Sjogren's syndrome susceptibility gene. PMID: 19032782
    29. OX40L may play an important role in the early phase of T cell activation and proliferation PMID: 19663699

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  • 亞細胞定位：
    Membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Tumor necrosis factor family
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:22164

    STRING: 10090.ENSMUSP00000028024

    UniGene: Mm.4994