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  4. Mouse Tumor necrosis factor receptor superfamily member 13B(TNFRSF13B) ELISA kit

Mouse Tumor necrosis factor receptor superfamily member 13B(TNFRSF13B) ELISA kit

  • 中文名稱：
    小鼠腫瘤壞死因子配體超家族成員13B(TNFSF13B)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL023971MO
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠腫瘤壞死因子配體超家族成員13B(TNFSF13B)酶聯(lián)免疫試劑盒（CSB-EL023971MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的TNFRSF13B含量。TNFRSF13B 作為一個靶點，它在免疫調(diào)節(jié)等生理過程中發(fā)揮重要作用。研究發(fā)現(xiàn)其信號通路與 B 細胞的增殖、分化密切相關(guān)。對 TNFRSF13B 的深入研究有助于揭示免疫相關(guān)疾病的發(fā)病機制，為免疫疾病的治療提供新的靶點和思路。試劑盒檢測范圍為78 pg/ml- 5000 pg/ml，適用于探索B細胞相關(guān)疾病的發(fā)病機制、藥物篩選或免疫調(diào)節(jié)研究等科研場景；為研究小鼠模型中的B細胞功能調(diào)控及TNFSF13B信號通路提供可靠工具本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Tnfrsf13b ELISA Kit; Taci ELISA Kit; Tumor necrosis factor receptor superfamily member 13B ELISA Kit; Transmembrane activator and CAML interactor ELISA Kit; CD antigen CD267 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    78 pg/ml - 5000 pg/ml
  • 靈敏度：
    19.5 pg/ml
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
  • 基因功能參考文獻：
    1. Data (including data from studies in knockout mice and cells from such mice) suggest that Taci in peritoneal and adipose tissue macrophages is involved in regulation of adipogenesis leading to obesity. PMID: 29871859
    2. results suggest that TACI A181E heterozygosity results in TACI haploinsufficiency with increased susceptibility to pneumococcal infection PMID: 27609654
    3. this study shows that increased TACI expression in B cells derived from non-obese diabetic mice contributes to the pathogenesis of type 1 diabetes NOD mice PMID: 27444337
    4. splenic B cells from TACI-deficient (TACI- / -) mice were unable to secrete IL-10 following TLR stimulation, and TACI- / - mice had undetectable basal serum concentrations of IL-10. PMID: 26139429
    5. Taci (-/-) mice and BAFF transgenic mice both develop signs of human Systemic Lupus Erythematosus. PMID: 25866827
    6. Elimination of B lymphocyte stimulator receptor 3 (BR-3) and TACI inhibits the development of SLE in NZM mice. PMID: 25989238
    7. TACI deficiency has a role in alternatively activated macrophage phenotype and susceptibility to Leishmania infection PMID: 26170307
    8. The released sTACI is an immunoregulator that shares decoy functions with atacicept. It reflects systemic and compartmentalized B cell accumulation and activation. PMID: 25505277
    9. Mice lacking TACI are able to clear Citrobacter rodentium, a model pathogen for severe human enteritis, more rapidly than did wild type mice. PMID: 25271628
    10. reduced TACI expression is responsible for the unresponsiveness of XID mouse to TI-2 Ags and BCR activation controls TACI expression. PMID: 24646744
    11. TACI is dispensable for the development of SLE in NZM mice. BAFF-TACI interactions contribute to SLE. PMID: 23334904
    12. TACI promotes sustained Blimp-1 expression by B cells responding to antigen, which in turn limits B-cell clonal expansion and facilitates differentiation of long-lived antibody-secreting cells. PMID: 21984806
    13. Mice deficient in TACI, a receptor for BLyS and APRIL, mounted an initial antiviral B cell response similar to that generated in WT mice but failed to sustain protective Ab titers. PMID: 21881204
    14. The C76R TACI mutation disrupts B cell function with lymphoproliferation and immunoglobulin production defects. PMID: 21458042
    15. MyD88 controls a B cell-intrinsic, TIR-independent, TACI-dependent pathway for immunoglobulin diversification PMID: 20676093
    16. Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. PMID: 12594954
    17. TACI and BAFF-R are able to transduce signals that result in isotype switching in B cells. PMID: 15630136
    18. Review. Short-lived antibody forming cell populations and their proliferating progenitors express a TACI-predominant signature. PMID: 16919470
    19. This review defines the exact contribution of TACI receptor stimulation by specific triggers in vitro, enabling us to better understand the complex, context-dependent responses initiated by TACI in vivo. PMID: 17171762
    20. Data suggest a novel role for TACI in anti-chromatin B cell homeostasis and differentiation. PMID: 17369193
    21. Our findings corroborate the notion that B cell deviations contribute to type 1 diabetes development, and suggest a temporal regulation of TACI(high) expression, possibly influenced by the ongoing autoimmune process. PMID: 17656068
    22. TACI has dual B cell-autonomous functions, inhibiting prolonged B cell proliferation and stimulating plasma cell differentiation PMID: 17675489
    23. A review of TACI function including regulation of B cell function. PMID: 18514565
    24. findings demonstrate that low TACI expression may be a critical factor that determines the susceptibility of newborns to infections with encapsulated bacteria and the impaired immunogenicity of polysaccharide vaccines PMID: 18606649
    25. mTACI A144E mutation and its human counterpart, A181E, disrupt TACI signaling and impair TACI-dependent B-cell functions. PMID: 19605846

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  • 亞細胞定位：
    Membrane; Single-pass type III membrane protein.
  • 數(shù)據(jù)庫鏈接：