Rat Angiotensin converting enzyme,ACE ELISA Kit
-
中文名稱:大鼠血管緊張素轉(zhuǎn)化酶(ACE)酶聯(lián)免疫試劑盒
-
貨號:CSB-E04490r
-
規(guī)格:96T/48T
-
價格:¥3900/¥2500
-
其他:
產(chǎn)品詳情
-
產(chǎn)品描述:大鼠血管緊張素轉(zhuǎn)化酶(ACE)酶聯(lián)免疫試劑盒(CSB-E04490r)檢測血清、血漿、組織勻漿樣本中的ACE含量。ACE即血管緊張素轉(zhuǎn)換酶,是腎素-血管緊張素系統(tǒng)的關(guān)鍵酶。它可將血管緊張素 I 轉(zhuǎn)化為血管緊張素 II,使血管收縮、血壓升高。其在高血壓等心血管疾病中作用關(guān)鍵,對 ACE 的研究有助于開發(fā)降壓等相關(guān)藥物。試劑盒檢測范圍為31.25 ng/ml- 2000 ng/ml,靈敏度為7.81 ng/ml。適用于心血管疾病機(jī)制研究、高血壓動物模型評價、腎臟功能相關(guān)實(shí)驗(yàn)以及藥物干預(yù)效果分析等科研場景。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
-
別名:Ace ELISA Kit; Dcp1 ELISA Kit; Angiotensin-converting enzyme ELISA Kit; ACE ELISA Kit; EC 3.2.1.- ELISA Kit; EC 3.4.15.1 ELISA Kit; Dipeptidyl carboxypeptidase I ELISA Kit; Kininase II ELISA Kit; CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme ELISA Kit; soluble form] ELISA Kit
-
縮寫:
-
Uniprot No.:
-
種屬:Rattus norvegicus (Rat)
-
樣本類型:serum, plasma, tissue homogenates
-
檢測范圍:31.25 ng/ml - 2000 ng/ml
-
靈敏度:7.81 ng/ml
-
反應(yīng)時間:1-5h
-
樣本體積:50-100ul
-
檢測波長:450 nm
-
研究領(lǐng)域:Neuroscience
-
測定原理:quantitative
-
測定方法:Competitive
-
數(shù)據(jù)處理:
-
貨期:3-5 working days
引用文獻(xiàn)
- Cardioprotective Effect of Peperomia pellucida against Doxorubicin-Induced Cardiotoxicity in Wistar Rats via Modulation of Electrocardiographic and Cardiac Biomarkers EA Archibong, JA Beshel, IA Okon,Journal of Pharmacopuncture,2024
- Protective Role of Kelulut Honey against Toxicity Effects of Polystyrene Microplastics on Morphology, Hormones, and Sex Steroid Receptor Expression in the Uterus of Rats NH Amran,Toxics,2023
- In Vivo Antihypertensive Activity and UHPLC-Orbitrap-HRMS Profiling of Cuphea ignea A. DC. WM Ismail,American Chemical Society,2022
- Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats SY Park,Antioxidants,2021
- Investigation of Angiotensin-Converting Enzyme Inhibitory Effects of Indonesian Traditional Medicine (Jamu) ARY Eff,Trop J Nat Prod Res,2021
- Black Soybean and Adzuki Bean Extracts Lower Blood Pressure by Modulating the Renin-Angiotensin System in Spontaneously Hypertensive Rats EW Jeong,Foods,2021
- Ginsenoside Rg3 Attenuates Early Hepatic Injury via Inhibiting PPARγ-and Ang II-Related Inflammation and Fibrosis in Type II Diabetic Mice Y Jiang,Natural Product Communications,2021
- Effect of high-intensity interval training on cardiac structure and function in rats with acute myocardial infarct B Wang,Biomedicine & Pharmacotherapy,2020
- Mechanisms Involved in Superiority of Angiotensin Receptor Blockade over ACE Inhibition in Attenuating Neuropathic Pain Induced in Rats N Hegazy,Neurotherapeutics,2020
- Evaluation of the cardioprotective effect of Casuarina suberosa extract in rats Abd Al Haleem E N, et al,Drug and Chemical Toxicology,2019
- Dynamic Variation of RAS on Silicotic Fibrosis Pathogenesis in Rats Zhang BN, et al,Current Medical Science,2019
- Ginsenoside Rg3 induces ginsenoside Rb1-comparable cardioprotective effects independent of reducing blood pressure in spontaneously hypertensive rats Yichuan Jiang.et al,Experimental and Therapeutic Medicine,2017
- The role of KCa3. 1 channels in cardiac fibrosis induced by pressure overload in rats Zhao LM et al,Pflugers Arch,2015
相關(guān)產(chǎn)品
相關(guān)問答
Could you please provide the following information regarding Rat Angiotensin converting enzyme, ACE ELISA Kit CSB-E04490r?
a. The active ingredient of the stop solution and its concentration ?
b. Can you please send the MSDS for this product?
I will send you MSDS by email.
Stop solution is 4N sulfuric acid.
Pls let me know if you have any further questions. Thank you.
靶點(diǎn)詳情
-
功能:Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm.
-
基因功能參考文獻(xiàn):
- ascorbic acid is able to prevent hypertension in offspring from prenatal inflammation exposure through ACE1 downregulation PMID: 27995995
- Data suggest that angiotensin converting enzyme 1 within median preoptic nucleus plays a critical role in the sustained hypertension seen in chronic intermittent hypoxia. PMID: 28536140
- Chromatin immunoprecipitation (ChIP) assays demonstrated an increase in FosB/DeltaFosB association with the ACE1 gene within the MnPO following CIH. FosB/DeltaFosB may transcriptionally target ACE1 within the MnPO following CIH to affect the downstream PVN region, which may influence SNA and blood pressure. PMID: 28003214
- Pomegranate peel extract consumption conferred protection against hypertension in the spontaneously hypertensive rat model. This finding was demonstrated by marked reduction in coronary ACE activity, oxidative stress, and vascular remodelling. PMID: 27710705
- ACE inhibitor treatment could counteract glutamate neurotoxicity by preventing the downregulation of glutamate decarboxylase 2 (Gad2). Taken together, ACE inhibition targets neurodegeneration triggered by environmental stress. PMID: 26697495
- the relationship between ACE and ACE2 activity, left ventricular function and gender in spontaneously hypertensive rats, was determined. PMID: 26010093
- Finding suggests the involvement of microRNAs in the cardioprotective action of ACE inhibition in acute renal injury. PMID: 26400542
- Transient ACE inhibition can produce a persistent modification of the cardiac fibroblast phenotype to one that is less inflammatory and fibrogenic. PMID: 26371174
- ACE and ACE 2 are expressed in lipopolysaccharide-induced lung injury and rebalanced by ACE inhibitor captopril PMID: 25768373
- Suppression of ACE-ANG II axis in the circulation and kidney tissue, combined with augmentation of the intrarenal vasodilator ACE2-ANG 1-7 axis, is the main mechanism responsible for blood pressure-lowering effects of chronic hypoxia in mRen2 rat. PMID: 25194129
- The study showed that both ACE and ACE-2 are overexpressed in the cardiac and renal tissues of animals with heart failure as compared with their sham controls. PMID: 25217176
- protein and beta-conglycinin may retard the progression of diabetic nephropathy by increasing insulin sensitivity, regulating lipid metabolism, improving renal function markers, and inhibiting ACE activity PMID: 25205218
- The increase in Ace mRNA levels was higher than that of Ace2 mRNA levels, leading to an elevated Ace/Ace2 ratio. PMID: 24781988
- ACE-inhibitory peptide LAP decreases blood pressure, inhibits smooth muscle cell hypertrophy and reduces the proliferation of collagen fibers. PMID: 23661144
- In the development of hypertension in diabetic rats, augmentation of circulating ACE activity precedes the sympathetic dysfunction. PMID: 23975725
- The results suggest that the gene silencing of intracellular ACE holds great potential in the treatment of cardiomyocyte apoptosis following ischemic reperfusion injury. PMID: 24126381
- study demonstrating that ACE shedding is regulated by NQO1 activation, which is possibly correlated with relieving hypertension in spontaneously hypertensive rats PMID: 23749777
- augmented tissue ACE activity in the coronary arterioles of obese subjects, which leads to reduced coronary dilation response to BK. PMID: 23603844
- Angiotensin converting enzyme gene expression is up-regulated in experimentally induced liver cirrhosis in rats. PMID: 24035938
- ACE downregulation by ACEI and ARB indicates that angiotensin II upregulates ACE through AT1 receptor PMID: 23733546
- Enalapril increases cardiac ACE levels in spontaneously hypertensive rats. PMID: 23706365
- Changes in the distribution of the ACE activity in aorta with increasing age in rat and by the action of L-NAME may play a role in development of atherosclerosis of aging vessels and inhibition of niric oxide formation. PMID: 21720771
- The expressions of ACE and ACE2 mRNA in lung tissue of the rats with paraquat poisoning are decreased. PMID: 20465954
- The Tc-Lis binds specifically to ACE, and the activity can be localized in Tg rat hearts that over-express human ACE-1 with a signal intensity that is sufficiently high to allow external imaging. PMID: 22498331
- culating angiotensin-converting enzyme decreased in diabetic females males PMID: 22378820
- The expression of VEGF, ACE, and MMP-9 mRNA levels in the resveratrol treated diabetic group decreased compared with values in the diabetic group. PMID: 22191573
- effect of inflammation on the expression levels of ACE and ACE-2 in two groups, adjuvant arthritis (AA) and healthy (control) rats. PMID: 21053061
- Local tissues from SHRs showed higher expressions of Ace1 mRNA and protein than those from the WKY rats. Ace1 promoter was mostly unmethylated in all of the tissues from both strains. PMID: 22311897
- ACEi, by moderating progenitor cell activation, restores glomerular architecture and prevents renal disease progression PMID: 21718676
- AngII infusion causes proteinuria-independent renal damage only in rats with genetically predetermined high ACE while rats with low ACE seemed to be protected against the detrimental effect of AngII. PMID: 21788250
- ACE expression and activity modifications are likely related to some of the physiological changes (cardiovascular, stress, cognition, metabolism function, water and energy balance) observed during and after sleep deprivation PMID: 21495912
- Suggest that elastase-2 may contribute as an alternative pathway for ANG II generation when ACE is inhibited in the rat vascular tissue. PMID: 21602471
- A vessel, organ and species specific pattern of distribution of endothelial ACE was observed (human vs. rat), providing an anatomical basis for organ and vessel specificity of the actions of the renin-angiotensin and kallikrein-kinin systems. PMID: 21167844
- Ang-(1-7) Mas receptors and AT2 receptors in hypothalamic paraventricular nucleus neurons play role in mediating tonic maintenance of renal sympathetic nerve activity. (Angiotensin 1-7) PMID: 16027241
- The attenuated counterbalancing effect of Ang-(1-7) on baroreflex function is lost in older rats, which may be attributable to diminished production of the peptide from neprilysin. (Angiotensin 1-7) PMID: 16009784
- Report the development of a stable and functional single-chain format of mAb 9B9 which specifically recognizes human and rat ACE represents a novel antibody-based reagent suitable for targeted delivery of drugs/genes to the pulmonary circulation. PMID: 20888351
- Treatment with the tissue specific ACE inhibitor quinapril revealed an important microvascular improvement, especially at arteriolar level. PMID: 20570682
- during mechanical ventilation ACE, via Ang II, mediates the inflammatory response of both healthy and preinjured lungs PMID: 20304959
- SMC and EC have a pathway for delivery of extracellular ACE to the nucleus, most likely involving cell surface receptor(s) and requiring transit through late endosome/lysosome compartments. PMID: 20022959
- The greater cardiac fibrosis in Brown Norway rats treated with isoproterenol correlates with the early and higher expression of proinflammatory factors. PMID: 18957386
- Nitric oxide synthase mRNA levels do not correlate with gene expression of angiotensin converting enzyme in selected brain areas. PMID: 11702851
- Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat Goldblatt model. PMID: 11875308
- Data show that angiotensin converting enzyme inhibition decreases cell turnover in the developing rat heart, which may contribute to cardiac growth impairment. PMID: 12193663
- results demonstrated that the rodent germinal angiotensin converting enzyme is released from the testicular sperm membrane when sperm enter the epididymis PMID: 12444051
- higher renal ACE activity is associated with more severe renal damage for a given amount of proteinuria, suggesting that renal ACE activity may be either a permissive or a promoting factor in the processes by which proteinuria leads to renal damage. PMID: 12806593
- Rats in the F(2) generation with high plasma ACE activity developed more fibrosis but to a similar degree of left ventricular hypertrophy compared with rats with low plasma ACE activity. PMID: 14527934
- activation of the enzymatic activity of ACE, the critical enzyme for determining the conversion of angiotensin I into the physiologically active angiotensin II, by chronic hypoxia in the carotid body. PMID: 14527966
- Binding increased in subfornical organ, organum vasculosum laminae terminalis, paraventricular nucleus, and median preoptic nucleus. In heart, greatest increase occurred at infarct scar and least in right ventricle. PMID: 14693687
- Identification of shear stress responsive elements in the angiotensin I converting enzyme promoter. PMID: 14872008
- TGF-beta 1 expression is correlated with ACE expression and could be a link between ACE gene polymorphism and diabetic vascular complications. PMID: 15047629
顯示更多
收起更多
-
亞細(xì)胞定位:[Angiotensin-converting enzyme, soluble form]: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm.
-
蛋白家族:Peptidase M2 family
-
組織特異性:Testis-specific isoform is expressed in spermatocytes, adult testis. Also expressed in brain, kidney, lung, skeletal muscle and heart.
-
數(shù)據(jù)庫鏈接:
Most popular with customers
-
Human Transforming Growth factor β1,TGF-β1 ELISA kit
Detect Range: 23.5 pg/ml-1500 pg/ml
Sensitivity: 5.8 pg/ml
-
-
-
Mouse Tumor necrosis factor α,TNF-α ELISA Kit
Detect Range: 7.8 pg/ml-500 pg/ml
Sensitivity: 1.95 pg/ml
-
-
-
-