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  4. Rat Cathepsin S(CTSS) ELISA kit

Rat Cathepsin S(CTSS) ELISA kit

  • 中文名稱：
    大鼠組織蛋白酶S(CTSS)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL006204RA
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠組織蛋白酶S(CTSS)酶聯(lián)免疫試劑盒（CSB-EL006204RA）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的CTSS含量。CTSS（組織蛋白酶S）是一種溶酶體半胱氨酸蛋白酶，參與抗原呈遞和細(xì)胞外基質(zhì)重塑。其在多種疾病如皮膚纖維瘤、肝纖維化中發(fā)揮作用，成為潛在的治療靶點(diǎn)。研究顯示，CTSS通過(guò)調(diào)節(jié)細(xì)胞外基質(zhì)成分，影響疾病進(jìn)程。試劑盒檢測(cè)范圍為15.6 pg/mL-1000 pg/mL，適用于體外實(shí)驗(yàn)中的蛋白表達(dá)水平監(jiān)測(cè)、疾病機(jī)制研究及藥物干預(yù)效果評(píng)價(jià)等科研領(lǐng)域，滿足細(xì)胞實(shí)驗(yàn)、動(dòng)物模型組織分析等多種研究需求本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說(shuō)明書。
  • 別名：
    Ctss ELISA Kit; Cathepsin S ELISA Kit; EC 3.4.22.27 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測(cè)范圍：
    15.6 pg/mL-1000 pg/mL
  • 靈敏度：
    3.9 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat CTSS in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %92
    Range %88-98
    1:2Average %97
    Range %93-105
    1:4Average %90
    Range %85-94
    1:8Average %98
    Range %94-102
  • 回收率：
    The recovery of rat CTSS spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 10398-110
    EDTA plasma (n=4)8480-89
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    10002.563 2.457 2.510 2.395
    5001.997 2.076 2.037 1.922
    2501.378 1.404 1.391 1.276
    1250.877 0.821 0.849 0.734
    62.50.567 0.554 0.561 0.446
    31.250.358 0.331 0.345 0.230
    15.60.227 0.240 0.234 0.119
    00.113 0.117 0.115
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
  • 基因功能參考文獻(xiàn)：
    1. Findings demonstrate that neuronal reactive oxygen species promote maturation of microglial CatS which facilitates activation of NMDA in the spinal dorsal horn. PMID: 28039043
    2. Inhibition of cathepsin S release is one mechanism that is responsible for purinergic P2X7 antagonist efficacy in neuropathic pain. PMID: 20629190
    3. Activated rat hepatic stellate cells express the class II transactivator, the invariant chain (CD74), the MHC class II molecules, as well as cathepsin S, all of which are known to be responsible for the initial steps of successful antigen presentation. PMID: 17178165
    4. endogenous CatS released by peripheral macrophages contributes to the maintenance of neuropathic hyperalgesia following nerve injury PMID: 17250968
    5. There is an altered expression of cathepsin S and cathepsin X in the spinal cord of a neuropathic pain model; including cellular distribution and pain development. PMID: 18700000
    6. under neuropathic conditions, noxious stimulation of primary afferent fibers induces release of CatS from microglia, which liberates FKN from dorsal horn neurons, thereby contributing to the amplification and maintenance of chronic pain PMID: 19474321

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  • 亞細(xì)胞定位：
    Lysosome. Secreted. Cytoplasmic vesicle, phagosome.
  • 蛋白家族：
    Peptidase C1 family
  • 組織特異性：
    Highest levels occur in the ileum followed by spleen, brain, thyroid, ovary and uterus. Low levels are found in the liver, kidney, jejunum and lung with lowest levels in the heart.
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: rno:50654

    UniGene: Rn.11347