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  4. Histone H2B Monoclonal Antibody

Histone H2B Monoclonal Antibody

  • 中文名稱：
    組蛋白H2B鼠單克隆抗體
  • 貨號(hào)：
    CSB-MA000324
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western blot analysis of 1) Hela, 2) 3T3, 3) Raw264.7, 4) Rat Brain, 5) Rat Kidney, diluted at 1:2000.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CUSABIO貨號(hào)：CSB-MA000324組蛋白H2B單克隆抗體是專為生命科學(xué)研究設(shè)計(jì)的核心實(shí)驗(yàn)試劑，靶向高度保守的核小體結(jié)構(gòu)蛋白Histone H2B。作為染色質(zhì)組裝的關(guān)鍵組分，H2B通過與H2A形成異源二聚體參與DNA包裝和表觀遺傳調(diào)控，在細(xì)胞周期進(jìn)程、DNA修復(fù)及基因表達(dá)中發(fā)揮重要作用。該抗體經(jīng)嚴(yán)格驗(yàn)證適用于人、小鼠、大鼠三大模式生物的實(shí)驗(yàn)體系，在Western Blot實(shí)驗(yàn)中可清晰識(shí)別約14kDa的目標(biāo)條帶，同時(shí)兼容ELISA檢測平臺(tái)，為研究者提供可靠的蛋白識(shí)別工具。在表觀遺傳調(diào)控機(jī)制研究、干細(xì)胞分化模型構(gòu)建、腫瘤微環(huán)境分析等前沿領(lǐng)域具有重要應(yīng)用價(jià)值，尤其適用于染色質(zhì)動(dòng)態(tài)變化觀察、組蛋白修飾互作研究及表觀遺傳藥物開發(fā)等科研場景。其高特異性和批次穩(wěn)定性已通過多物種組織裂解液測試驗(yàn)證，是探索基因表達(dá)調(diào)控網(wǎng)絡(luò)和疾病分子機(jī)制的首選抗體試劑。
  • Uniprot No.：
  • 基因名：
    HIST1H2BB
  • 別名：
    HIST1H2BB antibody; H2BFFHistone H2B type 1-B antibody; Histone H2B.1 antibody; Histone H2B.f antibody; H2B/f antibody
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic Peptide
  • 免疫原種屬：
    H, M, R
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 克隆號(hào)：
    24D11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
  • 基因功能參考文獻(xiàn)：
    1. Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants has been uncovered. PMID: 29643390
    2. RNF20 and H2Bub1 promotes chronic colonic inflammation and inflammation-associated colorectal cancer in mice and humans, partly by augmenting NF-kappaB activity and attenuating the antitumoral T cell response. PMID: 26854224
    3. RNF20-mediated H2B ubiquitination at DSBs plays a critical role in HRR through chromatin remodeling PMID: 21362548
  • 亞細(xì)胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Histone H2B family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4751

    OMIM: 602803

    KEGG: hsa:3018

    STRING: 9606.ENSP00000350580

    UniGene: Hs.553494