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TUBB1 Monoclonal Antibody

  • 中文名稱：
    TUBB1鼠單克隆抗體
  • 貨號(hào)：
    CSB-MA000192
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western blot analysis of 1) Hela, 2) Mouse Brain Tissue, 3) Rat Brain Tissue, diluted at 1:5000.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CUSABIO貨號(hào)：CSB-MA000192 TUBB1單克隆抗體是針對(duì)β-微管蛋白家族成員TUBB1研發(fā)的特異性檢測(cè)工具，該靶點(diǎn)在血小板形成過程中發(fā)揮關(guān)鍵作用，參與調(diào)控巨核細(xì)胞分化和血小板釋放機(jī)制，其表達(dá)異常與血小板減少癥等血液系統(tǒng)疾病密切相關(guān)。本產(chǎn)品采用雜交瘤技術(shù)制備，具有高親和力與優(yōu)異特異性，可精準(zhǔn)識(shí)別人類、小鼠及大鼠樣本中TUBB1蛋白，適用于ELISA檢測(cè)和Western Blot免疫印跡實(shí)驗(yàn)，滿足不同實(shí)驗(yàn)體系需求。經(jīng)嚴(yán)格驗(yàn)證的抗體性能可有效支持血小板生成機(jī)制研究、巨核細(xì)胞分化過程分析以及血小板相關(guān)疾病的分子機(jī)制探索，為血液系統(tǒng)疾病研究、心血管病理模型構(gòu)建及藥物作用靶點(diǎn)篩選等科研領(lǐng)域提供可靠工具。該TUBB1抗體特別適用于體外培養(yǎng)細(xì)胞模型、組織裂解液等樣本的蛋白水平檢測(cè)，兼容常規(guī)SDS-PAGE及轉(zhuǎn)膜實(shí)驗(yàn)條件，是研究細(xì)胞骨架動(dòng)態(tài)調(diào)控與血小板功能關(guān)聯(lián)性的理想選擇。
  • Uniprot No.：
  • 基因名：
  • 別名：
    2810484G07Rik antibody; beta 1 tubulin antibody; Beta tubulin 1, class VI antibody; Beta-tubulin antibody; Class VI beta tubulin antibody; dJ543J19.4 antibody; M(beta)1 antibody; TBB1_HUMAN antibody; TUBB1 antibody; Tubulin beta 1 class VI antibody; Tubulin beta-1 chain antibody; Tubulin, beta 1 antibody; tubulin, beta1 antibody
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic Peptide
  • 免疫原種屬：
    H, R, M
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 克隆號(hào)：
    29E1
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • 基因功能參考文獻(xiàn)：
    1. Neonatal platelets exhibit low levels of the Stx11-Munc18b complex (essential component of the SNARE machinery) and of beta1-tubulin. These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion. PMID: 29044293
    2. novel DCX mutation (p.D90G, NP_000546.2) appeared to be a major causative variant, whereas the novel mutation of TUBB1 (p.R62fsX, NP_110400.1) was found only in patients with more-severe intellectual disability in Familial pachygyria PMID: 26743950
    3. Analysis of the TUBB1 gene revealed three known missense variants in heterozygous state which in combination might explain the beta1-tubulin defect. PMID: 26540125
    4. TUBB1 R307H SNP is significantly associated with the degree of thrombocytopenia in congenital and acquired platelet disorders, and may affect platelets by altering microtubule behavior. PMID: 25529050
    5. Data indicate that ABCB1 protein, beta tubulin I and III (betaI, and betaIII tubulin) might contribute to the multidrug resistance (MDR) of MCF7/DOC and be potential therapeutic targets for overcoming MDR of breast cancer. PMID: 24894670
    6. TUBB1 mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia. PMID: 24344610
    7. our findings define beta-tubulin VI as a hematologic isotype with significant genetic variation in humans that may affect the myelosuppresive action of microtubule-binding drugs PMID: 22805305
    8. homozygous status of P43 genetic polymorphism causes alterations in platelet ultrastructure PMID: 21384078
    9. Studies show that BFBTS bound and modified beta-tubulin at residue Cys12, forming beta-tubulin-SS-fluorobenzyl. PMID: 19996274
    10. SLPI localizes in part along the megakaaryocyte and platelet cytoskeleton by virtue of specific interactions with beta1 tubulin. PMID: 15315966
    11. the platelet Q43P beta1-tubulin substitution is frequent in the healthy population and may protect men against arterial thrombosis PMID: 15956286
    12. The TUBB1 Q43P polymorphism, by causing a lower reactivity in platelets carrying the variant form of b1-tubulin, protects against thrombotic disorders but increases the risk of intracerebral hemorrhage in men. PMID: 17488662
    13. biophysical analysis of carboxy-terminal tail conformation of human beta-tubulin isotypes PMID: 17993481
    14. Mutation of the beta1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly. PMID: 18849486
    15. TUBB1 Q43P polymorphism does not protect against acute coronary syndrome and premature myocardial infarction. PMID: 19132255

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  • 相關(guān)疾?。?/div>
    Macrothrombocytopenia, autosomal dominant, TUBB1-related (MAD-TUBB1)
  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tubulin family
  • 組織特異性：
    Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 16257

    OMIM: 612901

    KEGG: hsa:81027

    STRING: 9606.ENSP00000217133

    UniGene: Hs.303023