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AJAP1 Antibody

  • 中文名稱：
    AJAP1兔多克隆抗體
  • 貨號：
    CSB-PA891947LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Mouse brain tissue, Mouse skeletal muscle tissue
      All lanes: AJAP1 antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 45 kDa
      Observed band size: 45 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA891947LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    CUSABIO's product CSB-PA891947LA01HU is a polyclonal antibody generated in the rabbit with the recombinant human AJAP1 protein (308-394AA) immunized. This anti-AJAP1 antibody is an unconjugated IgG. Its purity is greater than 95% using protein G purified. And it only can react with human and mouse AJAP1 protein, which is frequently reduced or lost in various tumors. The abnormal expression of AJAP1 is related to alterations in cell migration, invasion, increased tumor growth, and tumor vascularization. This AJAP1 antibody has passed multiple quality tests, including ELISA, WB, and IHC.

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) AJAP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    AJAP1
  • 別名：
    Adherens junction-associated protein 1 antibody; Ajap1 antibody; AJAP1_HUMAN antibody; Membrane protein shrew-1 antibody; MOT8 antibody; SHREW-1 antibody; SHREW1 antibody; Transmembrane protein SHREW1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Adherens junction-associated protein 1 protein (308-394AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，AJAP1 Antibody (CSB-PA891947LA01HU)，的標記方式是Non-conjugated。對于AJAP1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA891947LB01HU AJAP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA891947LC01HU AJAP1 Antibody, FITC conjugated
    Biotin CSB-PA891947LD01HU AJAP1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in cell adhesion and cell migration.
  • 基因功能參考文獻：
    1. Stable overexpression of AJAP1 promotes adherence, decreases invasion of glioma cells through an extracellular-like matrix, and slows migration in the presence of laminin. These observations are reversed by gene knockdown using multiple siRNAs. Additionally, overexpression of AJAP1 decreases colony formation in glioma cells. PMID: 29115565
    2. AJAP1 blocked epithelial-to-mesenchymal transition by interacting with beta-catenin and inhibiting its nuclear translocation, which suppressed zinc finger E-box binding homeobox 1 (ZEB1) transcription. PMID: 28383563
    3. EGFR/EGFRvIII remodels the cytoskeleton via epigenetic silencing of AJAP1 in glioma cells. PMID: 28634045
    4. Reduced Expression of Adherens Junctions Associated Protein 1 is associated with Recurrence of Hepatocellular Carcinoma After Curative Hepatectomy. PMID: 26122373
    5. These findings indicate that downregulated AJAP1 transcription may serve as a novel tumor biomarker to predict recurrence of ESCC after esophagectomy. PMID: 26397940
    6. Article summarizes and discusses current knowledge that may identify AJAP1 as a tumor suppressor in gliomas. [Review] PMID: 24807315
    7. Results show that AJAP1 is dysregulated at an early stage of gliomagenesis and may suppress glioma cell invasion and proliferation, which suggests that AJAP1 may be a potential diagnostic and prognostic marker for gliomas PMID: 24483339
    8. AJAP1 suppressed the expression of MAGEA2 and inhibited the transcriptional activity of MAGEA2 in glioma cells. PMID: 24481586
    9. We also identified a significant genetic association between caries of the mid- dentition tooth surfaces and AJAP1 (p value = 2e-8), a gene possibly involved in tooth development. PMID: 23064961
    10. This work shows the significant loss of expression of AJAP1 in glioblastoma and provides evidence of its role in the highly migratory characteristic of these tumors. PMID: 22241217
    11. Both genetic (gene deletion) and epigenetic alterations (promoter methylation) are likely mechanisms that inactivate the putative tumor suppressor AJAP1 in gliomas, which contributes to poor prognosis. PMID: 21439246
    12. Data show that overexpression of shrew-1 leads to preformation of an E-cadherin/EGF receptor/HER2/src-kinase/shrew-1 signaling complex and accelerated E-cadherin internalization. PMID: 19515834
    13. While a mutation was not detected in the coding region of the SHREW1 gene in oligodendrogliomas, SHREW1 expression restoration resulted in suppression of cell adhesion and migration, thus, SHREW1 inactivation may lead to oligodendroglial tumorigenesis. PMID: 16410724
    14. Adaptor protein complex AP-1B is involved in retaining shrew-1 at the basolateral membrane by postendocytic sorting mechanisms. PMID: 16707570
    15. shrew-1 has a function in the regulation of cellular invasion, which may involve its interaction with CD147 PMID: 17267690
    16. synergism between a signal peptide and a transmembrane segment to mediate plasma membrane localization is essential for structural and/or functional integrity of shrew-1 PMID: 18485053

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  • 亞細胞定位：
    Basolateral cell membrane; Single-pass type III membrane protein. Apical cell membrane; Single-pass type III membrane protein. Cell junction, adherens junction. Note=Mainly basolateral. Localization is mediated by AP1M2.
  • 組織特異性：
    Expressed in uterus and pancreas (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30801

    OMIM: 610972

    KEGG: hsa:55966

    STRING: 9606.ENSP00000367432

    UniGene: Hs.12473