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ARHGAP4 Antibody

  • 中文名稱:
    ARHGAP4兔多克隆抗體
  • 貨號(hào):
    CSB-PA256995
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA256995(ARHGAP4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA256995(ARHGAP4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    ARHGAP4
  • 別名:
    ARHGAP4 antibody; KIAA0131 antibody; RGC1 antibody; RHOGAP4 antibody; Rho GTPase-activating protein 4 antibody; Rho-GAP hematopoietic protein C1 antibody; Rho-type GTPase-activating protein 4 antibody; p115 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human ARHGAP4
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.
  • 基因功能參考文獻(xiàn):
    1. The relation between ARHGAP4 mutation and Mental retardation(MR) clinical characteristic is needed to be illuminated with participation of more MR patients PMID: 26707211
    2. ARHGAP4 rs2269368 was associated with risk of schizophrenia in a Han Chinese population. PMID: 24043878
    3. X-linked nephrogenic diabetes insipidus (NDI) and intellectual disability in two dizygotic twin brothers was caused by a novel contiguous deletion of 17,905 bp of the entire AVPR2 gene and intron 7 of the ARHGAP4 gene. PMID: 22965914
    4. A novel type of contiguous gene deletion of ARHGAP4 has been identified in unrelated Japanese kindreds with nephrogenic diabetes insipidus. PMID: 11754100
    5. ARHGAP4 may play some role in lymphocyte differentiation but partial loss of ARHGAP4 does not result in clinical immunodeficiency PMID: 18489790
    6. FNBP2, ARHGAP13, ARHGAP14 and ARHGAP4 constitute the FNBP2 family characterized by FCH, RhoGAP and SH3 domains. PMID: 12736724

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  • 亞細(xì)胞定位:
    Cytoplasm. Note=Just below the plasma membrane.
  • 組織特異性:
    Predominantly in hematopoietic cells (spleen, thymus and leukocytes); low levels in placenta, lung and various fetal tissues.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 674

    OMIM: 300023

    KEGG: hsa:393

    STRING: 9606.ENSP00000359045

    UniGene: Hs.701324