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ARHGAP4 Antibody

  • 中文名稱(chēng)：
    ARHGAP4兔多克隆抗體
  • 貨號(hào)：
    CSB-PA002032GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ARHGAP4
  • 別名：
    ARHGAP4 antibody; KIAA0131 antibody; RGC1 antibody; RHOGAP4 antibody; Rho GTPase-activating protein 4 antibody; Rho-GAP hematopoietic protein C1 antibody; Rho-type GTPase-activating protein 4 antibody; p115 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Human ARHGAP4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.
  • 基因功能參考文獻(xiàn)：
    1. The relation between ARHGAP4 mutation and Mental retardation(MR) clinical characteristic is needed to be illuminated with participation of more MR patients PMID: 26707211
    2. ARHGAP4 rs2269368 was associated with risk of schizophrenia in a Han Chinese population. PMID: 24043878
    3. X-linked nephrogenic diabetes insipidus (NDI) and intellectual disability in two dizygotic twin brothers was caused by a novel contiguous deletion of 17,905 bp of the entire AVPR2 gene and intron 7 of the ARHGAP4 gene. PMID: 22965914
    4. A novel type of contiguous gene deletion of ARHGAP4 has been identified in unrelated Japanese kindreds with nephrogenic diabetes insipidus. PMID: 11754100
    5. ARHGAP4 may play some role in lymphocyte differentiation but partial loss of ARHGAP4 does not result in clinical immunodeficiency PMID: 18489790
    6. FNBP2, ARHGAP13, ARHGAP14 and ARHGAP4 constitute the FNBP2 family characterized by FCH, RhoGAP and SH3 domains. PMID: 12736724

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  • 亞細(xì)胞定位：
    Cytoplasm. Note=Just below the plasma membrane.
  • 組織特異性：
    Predominantly in hematopoietic cells (spleen, thymus and leukocytes); low levels in placenta, lung and various fetal tissues.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 674

    OMIM: 300023

    KEGG: hsa:393

    STRING: 9606.ENSP00000359045

    UniGene: Hs.701324