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CD300C Antibody

  • 中文名稱：
    CD300C兔多克隆抗體
  • 貨號(hào)：
    CSB-PA006279
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of RAT-kidney cells using CD300c Polyclonal Antibody
    • Western Blot analysis of rat kidney cells using CD300c Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CD300 antigen-like family member C antibody; CD300c antibody; CD300c antigen antibody; CD300c molecule antibody; CLM-6 antibody; CLM6_HUMAN antibody; CMRF-35 antibody; CMRF-35A antibody; CMRF35 antibody; CMRF35 antigen antibody; CMRF35 leukocyte immunoglobulin-like receptor antibody; CMRF35-A1 antibody; CMRF35-like molecule 6 antibody; CMRF35A antibody; CMRF35A leukocyte immunoglobulin-like receptor antibody; CMRF35A1 antibody; IgSF16 antibody; Immunoglobulin superfamily member 16 antibody; LIR antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CD300c.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. Results show that CD300c is exclusively expressed on CD56bright natural killer cells and differentially binds to phosphatidylethanolamine and phosphatidylserine. This expression is under the regulation of STAT5 and Il-4. PMID: 27040328
    2. potential role in inflammatory responses PMID: 23571507
    3. engagement of CD300C led to Fc receptor gamma-dependent activation of mast cells and monocytes PMID: 23372157
    4. differential expression on human TH1 and TH17 cell memory subsets PMID: 22046970
    5. CD300a and CD300c receptors are indistinguishable on the surface of natural killer (NK) cells. The tyrosine residue in the third ITIM motif, Tyr-267-Ala, is the most important residue for execution of the inhibitory signal. PMID: 20656921
    6. CMRF35A and CMRF35H have roles in immunoglobulin signaling; CMRF35A induces cellular activation and effector function [review] PMID: 12456026
    7. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs; CD300a/c RNA and surface expression were downregulated after stimulation of pDCs with TLR7 and TLR9 ligands PMID: 18535206

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    CD300 family
  • 組織特異性：
    Present on the surface of monocytes, neutrophils, a proportion of peripheral blood T- and B-lymphocytes and lymphocytic cell lines.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19320

    OMIM: 606786

    KEGG: hsa:10871

    STRING: 9606.ENSP00000329507

    UniGene: Hs.2605