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CERS4 Antibody

  • 中文名稱：
    CERS4兔多克隆抗體
  • 貨號：
    CSB-PA046553
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from COLO cells, Jurkat cells and HUVEC cells, using LASS4 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using LASS4 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CERS4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CERS4
  • 別名：
    CERS4; LASS4; Ceramide synthase 4; CerS4; LAG1 longevity assurance homolog 4; Sphingosine N-acyltransferase CERS4
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human LASS4.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor.
  • 基因功能參考文獻(xiàn)：
    1. nine SNPs in the ceramide synthase 4 (CERS4) region were associated with circulating C23:0 levels (adjusted P<5x10-2) PMID: 29738550
    2. These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths. PMID: 26887952
    3. mRNA level of CerS4 is higher in cancerous cell lines and decreases following the induction of apoptosis. PMID: 25779024
    4. Co-expression of CerS2 with CerS4/CerS6 reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis. we detected no effect on cell proliferation. PMID: 23538298
    5. The linkage and association of phospholipid transfer protein activity to LASS4 were studied. PMID: 21757428

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  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23747

    OMIM: 615334

    KEGG: hsa:79603

    STRING: 9606.ENSP00000251363

    UniGene: Hs.515111