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  4. CNOT9 Antibody, Biotin conjugated

CNOT9 Antibody, Biotin conjugated

  • 中文名稱：
    CNOT9兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA842140LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CNOT9 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CNOT9 antibody; RCD1 antibody; RQCD1CCR4-NOT transcription complex subunit 9 antibody; Cell differentiation protein RQCD1 homolog antibody; Rcd-1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CCR4-NOT transcription complex subunit 9 protein (1-258AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation. Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.
  • 基因功能參考文獻(xiàn)：
    1. Data indicate a recurrent somatic C > T change causing a P131L mutation in the RQCD1 (Required for Cell Differentiation1 Homolog) gene identified through whole exome sequencing of 20 metastatic melanomas. PMID: 25544760
    2. Crystal structures of the DDX6, CNOT1 and CNOT9 complexes. PMID: 24768538
    3. Crystal structure of the DDX6, CNOT9 and CNOT1 complex. PMID: 24768540
    4. Our findings in this study imply the functional mechanism of RQCD1 in the Akt activity regulation as a mediator in the EGFR-signaling pathway PMID: 20878056
    5. mammalian protein is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation PMID: 12356739
    6. CCR4 plays a role in the regulation of certain endogenous RARalpha target genes and RCD1 and CCR4 might mediate their function through their interaction with NIF-1 PMID: 18180299
    7. Report involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells. PMID: 19724902

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  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm, P-body.
  • 蛋白家族：
    CNOT9 family
  • 組織特異性：
    Detected in spleen, thymus, prostate, testis, ovary and intestine.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10445

    OMIM: 612054

    KEGG: hsa:9125

    STRING: 9606.ENSP00000273064

    UniGene: Hs.148767