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  4. DDX25 Antibody

DDX25 Antibody

  • 中文名稱：
    DDX25兔多克隆抗體
  • 貨號：
    CSB-PA006615GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    DDX25
  • 別名：
    DDX25 antibody; GRTHATP-dependent RNA helicase DDX25 antibody; EC 3.6.4.13 antibody; DEAD box protein 25 antibody; Gonadotropin-regulated testicular RNA helicase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human DDX25
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development.
  • 基因功能參考文獻：
    1. Analysed the association of GRTH gene IVS6+55G/T and c.852C/T polymorphisms with male infertility. The c.852 T allele was associated with an increased risk of male infertility (OR: 3.16, P = 0.008), whereas IVS6+55G/T allele conferred no risk. PMID: 24168058
    2. multifunctional RNA helicase that is an essential regulator of spermatogenesis PMID: 19875492
    3. SNP IVS6+55G-->T and c.852C-->T of GRTH gene may be associated with male infertility with azoospermia or severe oligozoospermia. PMID: 16293649
    4. Data show that the Arg(242)His missense mutation of the GRTH/DDX25 gene associated with expression of a protein with reduced basicity, and the absence of the phospho-GRTH species, could impact on germ cell development and/or function. PMID: 17848414
    5. The association of GRTH mutations with male infertility underlines the importance of GRTH as a central, post-transcriptional regulator of spermatogenesis. PMID: 17889551

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    DEAD box helicase family
  • 組織特異性：
    Highly expressed in the Leydig and germ cells of the testis and weakly expressed in the pituitary and hypothalamus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18698

    OMIM: 607663

    KEGG: hsa:29118

    STRING: 9606.ENSP00000263576

    UniGene: Hs.420263