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  4. IER2 Antibody, Biotin conjugated

IER2 Antibody, Biotin conjugated

  • 中文名稱：
    IER2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA01729D0Rb
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) IER2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    IER2
  • 別名：
    IER2 antibody; ETR101 antibody; PIP92 antibody; Immediate early response gene 2 protein antibody; Protein ETR101 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Immediate early response gene 2 protein (1-223AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    DNA-binding protein that seems to act as a transcription factor. Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells. May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo. Promotes cell motility, seems to stimulate tumor metastasis.
  • 基因功能參考文獻(xiàn)：
    1. IER2 promoted hepatocellular carcinoma cell adhesion and motility by directly increasing ITGB1 expression and subsequently activating the ITGB1FAKSrcpaxillin signal pathway. PMID: 27840969
    2. results from western blot analysis showed that the activity of the focal adhesion kinase (FAK) can be regulated by IER2. PMID: 26260137
    3. ectopic Ier2 expression promoted the motility and invasiveness of poorly metastatic 1AS pancreatic tumor cells in vitro PMID: 22120713
    4. the functioning of ETR101 as a transcriptional activator for the gene ISYNA1 PMID: 19584537
  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    IER family
  • 組織特異性：
    Expressed in activated T-cells (at protein level). Expression increases in metastatic tumor cells (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28871

    KEGG: hsa:9592

    STRING: 9606.ENSP00000292433

    UniGene: Hs.501629