KCNN1 Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

Q92952
基因名：

KCNN1
別名：

KCNN1; SK; Small conductance calcium-activated potassium channel protein 1; SK1; SKCa 1; SKCa1; KCa2.1
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human KCNN1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.
基因功能參考文獻(xiàn)：
1. SK current is increased via the enhanced activation of CaMKII in patients with atrial fibrillation. PMID: 29737974
2. Differentiated dopaminergic neurons expressed low levels of SK2 channels and high levels of SK1 and SK3 channels. PMID: 24434522
3. Decreased expression of small-conductance Ca2+-activated K+ channels SK1 and SK2 in human chronic atrial fibrillation. PMID: 22154908
4. IK1-like immunoreactivity is observed in enteric neurons of human colon, with a significant decrease of IK1-positive cells in inflamed colon from patients with Crohn's disease and ulcerative colitis. PMID: 12598727
亞細(xì)胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Potassium channel KCNN family, KCa2.1/KCNN1 subfamily
數(shù)據(jù)庫鏈接：

HGNC: 6290

OMIM: 602982

KEGG: hsa:3780

UniGene: Hs.158173