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SOCS4 Antibody

  • 中文名稱：
    SOCS4兔多克隆抗體
  • 貨號(hào)：
    CSB-PA022393ESR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: SOCS4 antibody at 4.25 μg/ml
      + Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 60 kDa
      Observed band size: 60 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA022393ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA022393ESR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SOCS4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CIS4 antibody; Cish4 antibody; Cytokine inducible SH2 protein 4 antibody; DKFZp686J1568 antibody; HSPC060 antibody; SH2 domain containing SOCS box protein antibody; SOCS-4 antibody; SOCS-7 antibody; SOCS4 antibody; SOCS4_HUMAN antibody; SOCS6 antibody; SOCS7 antibody; SSI4 antibody; STAI4 antibody; STAT induced STAT inhibitor 4 antibody; STAT4 antibody; STATI4 antibody; Suppressor of cytokine signaling 4 antibody; Suppressor of cytokine signaling 7 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Suppressor of cytokine signaling 4 protein (1-270AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.
  • 基因功能參考文獻(xiàn)：
    1. Significantly higher levels of suppressor of cytokine signalling proteins SOCS3 and SOCS4 in non-healing chronic wounds compared to the healing/healed chronic wounds were observed at the transcript level. PMID: 27635428
    2. miR-25 promotes the migration and invasion of thyroid cancer cells by directly binding to the 3'-UTR of SOCS4 that leads to the inhibition of SOCS4. PMID: 26437444
    3. This study showed that increased protein levels of SOCS-4 and SOCS-7 in Alzheimer's disease brains. PMID: 25286386
    4. SOCS4 is a known inhibitor of epidermal growth factor (EGF) receptor signalling, and functional studies demonstrated specific upregulation of EGF-dependent immune stimulation in affected family members. PMID: 25639832
    5. Identified is a conserved region of about 70 residues in the N-terminal domains of SOCS4 and 5 that is predicted to be more ordered than the surrounding sequence. PMID: 22423360
    6. The expression of SOCS4 seems to be controlled epigenetically and is often weakly expressed in gastric cancer tissue and cell lines. SOCS4 methylation status could be a predictor of gastric cancer prognosis. PMID: 22127425
    7. Higher mRNA expression levels of SOCS1, 3, 4 and 7 are significantly associated with earlier tumour stage and better clinical outcome in human breast cancer. PMID: 20433750
    8. These data suggest that miRNAs play an important role in the regulation of cytokine-inducible Src homology and SOCS expression in epithelial cells in response to C. parvum infection. PMID: 20486857
    9. the expression of SOCS5 and its closest homolog SOCS4 is elevated in cells following treatment with EGF, similar to several negative feedback regulators of EGFR whose expression is up-regulated upon receptor activation. PMID: 15590694
    10. The structure of the SOCS4-ElonginC-ElonginB complex reveals a distinct SOCS structural class. PMID: 17997974

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  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 19392

    OMIM: 616337

    KEGG: hsa:122809

    STRING: 9606.ENSP00000341327

    UniGene: Hs.744302