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CD93 Recombinant Monoclonal Antibody

  • 中文名稱：
    CD93重組抗體
  • 貨號：
    CSB-RA865099MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of Macaca fascicularis CD93 with Anti-CD93 Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CD93 (CSB-MP4279MOV) at 2 μg/mL can bind Anti-CD93 recombinant antibody. The EC50 is 0.1669-0.3513 ng/mL.
    • The Binding Activity of Human CD93 with Anti-CD93 Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD93 (CSB-MP865099HU) at 2 μg/mL can bind Anti-CD93 recombinant antibody. The EC50 is 0.6639-1.173 ng/mL.
    • Untransfected CHO-K1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CD93 Recombinant Monoclonal Antibody（CSB-RA865099MA1HU）是針對CD93靶點開發(fā)的高特異性重組單克隆抗體。CD93是一種跨膜糖蛋白，廣泛表達(dá)于內(nèi)皮細(xì)胞和免疫細(xì)胞表面，參與細(xì)胞粘附、血管生成及免疫調(diào)節(jié)等生物學(xué)過程，其異常表達(dá)與炎癥反應(yīng)、腫瘤微環(huán)境調(diào)控等研究領(lǐng)域密切相關(guān)。本抗體通過ELISA等嚴(yán)格驗證，展現(xiàn)出優(yōu)異的抗原結(jié)合能力與檢測靈敏度，適用于體外實驗中CD93蛋白的定性與半定量分析。該重組抗體采用哺乳動物表達(dá)系統(tǒng)制備，具有高批次間一致性和低交叉反應(yīng)性特征，可滿足細(xì)胞功能研究、蛋白互作分析及信號通路探索等科研需求，尤其適用于血管生成相關(guān)機制研究、免疫細(xì)胞表型鑒定以及腫瘤微環(huán)境模型中CD93的功能解析。其穩(wěn)定性和可重復(fù)性為體外實驗（如細(xì)胞培養(yǎng)體系中的蛋白檢測）提供可靠工具，適用于分子生物學(xué)和細(xì)胞生物學(xué)領(lǐng)域的科研探索。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD93 Recombinant Monoclonal Antibody
  • 反應(yīng)種屬：
    Human, Macaca fascicularis
  • 免疫原：
    Recombinant Human CD93 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    15B9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.
  • 基因功能參考文獻(xiàn)：
    1. Report increased CD93 expression in patients with chronic plaque psoriasis and propose the C allele of rs2749817 as a new risk allele for psoriasis. PMID: 28421233
    2. Results show that CD93 and MMRN2 are co-expressed in the blood vessels of various tumors and their interaction modulates the angiogenic process. PMID: 28912033
    3. These findings identify novel protein interactions involving CLEC14A, CD93 and CD248 with MMRN2 as targetable components of vessel formation PMID: 28671670
    4. CD93 and Other Plasma Cell Survival Factor Genes Associated with Measles-Specific Antibody Response after Vaccination PMID: 27529750
    5. Soluble expression of disulfide-bonded C-type lectin like domain of human CD93 in the cytoplasm of Escherichia coli. The recombinant protein could alter LPS pro-inflammatory activity on THP1 cells. PMID: 27742562
    6. Vascular CD93 expression is elevated in nasopharyngeal carcinoma and is correlated with T classification, N classification, distant metastasis, clinical stage and poor prognosis (all P < 0.05). In addition, overexpression of CD93 promoted angiogenesis in vitro. PMID: 27255994
    7. both transmembrane and soluble CD93 are overexpressed in patients with neovascular Age-Related Macular Degeneration. PMID: 27859225
    8. Elevated serum sCD93 levels reflected exacerbated status of allergic diseases, including CSU [chronic spontaneous urticaria ], AR[allergic rhinitis], and asthma. ICS [inhaled corticosteroid] use significantly diminished serum sCD93 levels in steroid-naive patients with BA[Bronchial asthma]. This result may suggest sCD93 in serum as a therapeutic marker for allergic inflammation. PMID: 28332366
    9. Data show that CD93 antigen proved to be phosphorylated on tyrosine 628 and 644 following cell adhesion on laminin through dystroglycan. PMID: 26848865
    10. CD93 expression identifies a predominantly cycling, non-quiescent leukemia-initiating cell population in MLL-rearranged AML, providing opportunities for selective targeting and eradication of LSCs. PMID: 26387756
    11. The T/T genotype of SNP rs2749817 of CD93 is associated with disseminated cancer. PMID: 26008729
    12. CD93 is a key regulator of glioma angiogenesis and vascular function, acting via cytoskeletal rearrangements required for cell-cell and cell-matrix adhesion. PMID: 26363010
    13. These data support a mechanism whereby gC1qR plays an important role in HPV-16 E2-induced human cervical squamous carcinoma cell apoptosis via a mitochondria-dependent pathway. PMID: 25288439
    14. The data indicate that gC1qR inhibits viability, migration and proliferation of cervical squamous cells carcinoma via the p38 MAPK signalling pathway. PMID: 23052251
    15. Antibody-dependent enhancement of parvovirus B19 involves an alternative mechanism mediated by the heat-sensitive complement factor C1q and its receptor, CD93. PMID: 24807719
    16. Expression of CD93 on the lymphocyte population of peripheral blood cells from infants at 1 month after birth was also significantly decreased, compared with that for neonatal umbilical cord blood. PMID: 24033555
    17. HPV 16 E2 induces apoptosis by silencing the gC1qR gene or inhibiting p38 MAPK/JNK signalling in cervical squamous cell carcinoma PMID: 23651874
    18. These data support a mechanism whereby gC1qR induces apoptosis through the mitochondrial and p53-dependent pathways in cervical squamous cell carcinoma. PMID: 23268996
    19. soluble EGF-like domain containing CD93 protein is a novel angiogenic factor acting on the endothelium PMID: 23272129
    20. [review] Following a comprehensive summary of CD93 expression patterns, this review focuses on recent findings that address the putative function of CD93 in inflammation and innate immunity. PMID: 22206251
    21. Data show that Pic, a class 2 SPATE protein produced by Shigella flexneri 2a targets a broad range of human leukocyte glycoproteins including CD43, CD44, CD45, CD93, CD162 and the surface-attached chemokine fractalkine. PMID: 21768350
    22. Results suggest that the plasma concentration of soluble CD93 is a potential novel biomarker for Coronary Artery Disease (CAD), including MI. PMID: 21332844
    23. expression on naive T lymphocytes (CD4(+)CD45RA (+) cells) in human neonatal umbilical cord blood PMID: 20512406
    24. both B1 receptor and gC1q receptor are involved in the vascular leakage induced by hereditary and acquired angioedema plasma. PMID: 19796797
    25. To clarify the cellular and molecular properties of C1qRp it has been demonstrated that C1q does not show enhanced binding to C1qRp-transfected cells, is not a receptor for C1q, and is identical to CD93 with functions relevant to intercellular adhesion. PMID: 11994479
    26. C1qRp defines a new human stem cell population with hematopoietic and hepatic potential PMID: 12140365
    27. O-glycosylation is important in the stable cell surface expression of C1qRP/CD93 PMID: 12891708
    28. Taken together, these findings indicate that the expression of the CD93 molecule identified by CD93 mAb (mNI-11) is dramatically decreased on U937 cells with apoptotic properties PMID: 18094537
    29. RNAi-mediated suppression of gC1qR/p32 markedly reduced HTNV binding and infection in human lung epithelial A549 cells PMID: 18834607

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15855

    OMIM: 120577

    KEGG: hsa:22918

    STRING: 9606.ENSP00000246006

    UniGene: Hs.97199