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GPA33 Recombinant Monoclonal Antibody

  • 中文名稱：
    GPA33重組抗體
  • 貨號：
    CSB-RA245537A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA245537A0HU diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-RA245537A0HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA245537A0HU GPA33重組單克隆抗體是針對人源糖蛋白A33（GPA33）設(shè)計的高特異性科研工具。GPA33作為一種跨膜糖蛋白，在正常胃腸道上皮細(xì)胞和結(jié)直腸癌等腫瘤組織中特異性表達(dá)，其參與細(xì)胞間粘附及信號調(diào)控的功能使其成為胃腸道腫瘤微環(huán)境研究的重要靶點(diǎn)。本抗體采用重組技術(shù)制備，經(jīng)ELISA和免疫組化（IHC）雙重驗(yàn)證，在IHC應(yīng)用中推薦使用1:50至1:200的稀釋比例，能清晰顯示石蠟包埋組織中靶蛋白的定位與表達(dá)水平，背景信號低且重復(fù)性優(yōu)異。該產(chǎn)品適用于胃腸道腫瘤病理學(xué)分析、腫瘤標(biāo)志物篩選及細(xì)胞膜表面蛋白功能研究，可為探索GPA33在腫瘤發(fā)生發(fā)展中的分子機(jī)制、評估腫瘤組織特異性表達(dá)模式提供可靠支持，同時滿足體外實(shí)驗(yàn)中對蛋白互作及信號通路研究的精準(zhǔn)檢測需求。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Cell surface A33 antigen (Glycoprotein A33), GPA33
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human GPA33
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    4H4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    May play a role in cell-cell recognition and signaling.
  • 基因功能參考文獻(xiàn)：
    1. A33 shows similar sensitivity to but is more specific than CDX2 as an immunomarker of colorectal carcinoma PMID: 28226180
    2. A33 expression is directly correlated to colorectal tumor differentiation. PMID: 27272411
    3. Data indicate that EpCAM- and A33-Exos were released from the apical and basolateral surfaces, respectively. PMID: 23230278
    4. Data indicate positive staining was observed for both A33 expression and KRN330 binding from patients biopsied on Day 8, 9 or 14 following initial dosing of 3 mg/kg. PMID: 23294608
    5. The A33-dependent incorporation of B5 into extracellular enveloped vaccinia virions is mediated through an interaction between their lumenal domains. PMID: 22623777
    6. Increased interaction between vaccinia virus proteins A33 and B5 is detrimental to infectious extracellular enveloped virion production. PMID: 22623782
    7. cloning, chromosomal localizations, exon-intron structures and transcription start sites - target gene for the intestine-specific homeobox transcription factor, CDX1. PMID: 12114523
    8. Regulation of A33 antigen expression by GKLF. PMID: 12853980
    9. This work has demonstrated that the antigen is both highly immobile and extremely persistent-retaining its surface localization for a turnover halflife of greater than 2 days. PMID: 18236042

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4445

    OMIM: 602171

    KEGG: hsa:10223

    STRING: 9606.ENSP00000356842

    UniGene: Hs.651244