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  4. Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1)

Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1)

  • 中文名稱：
    Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 1(CASTOR1)
  • 貨號：
    CSB-YP848815HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 1(CASTOR1)
  • 貨號：
    CSB-EP848815HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 1(CASTOR1)
  • 貨號：
    CSB-EP848815HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 1(CASTOR1)
  • 貨號：
    CSB-BP848815HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 1(CASTOR1)
  • 貨號：
    CSB-MP848815HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CASTOR1
  • Uniprot No.：
  • 別名：
    GATL3_HUMAN; GATS-like protein 3; GATSL3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-329
  • 氨基酸序列
    MELHILEHRV RVLSVARPGL WLYTHPLIKL LFLPRRSRCK FFSLTETPED YTLMVDEEGF KELPPSEFLQ VAEATWLVLN VSSHSGAAVQ AAGVTKIARS VIAPLAEHHV SVLMLSTYQT DFILVREQDL SVVIHTLAQE FDIYREVGGE PVPVTRDDSS NGFPRTQHGP SPTVHPIQSP QNRFCVLTLD PETLPAIATT LIDVLFYSHS TPKEAASSSP EPSSITFFAF SLIEGYISIV MDAETQKKFP SDLLLTSSSG ELWRMVRIGG QPLGFDECGI VAQIAGPLAA ADISAYYIST FNFDHALVPE DGIGSVIEVL QRRQEGLAS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
  • 基因功能參考文獻：
    1. 1.8 A crystal structure of arginine-bound CASTOR1 PMID: 27487210
    2. Study establishes the CASTOR1 homodimer and CASTOR1-CASTOR2 heterodimer as arginine sensors for the mTORC1 pathway. PMID: 26972053
    3. This genome wide association study identified a new rheumatoid arthritis susceptibility locus mapping to 22q12 in the GATSL3 gene. PMID: 24449572
  • 亞細胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    GATS family
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 34423

    OMIM: 617034

    KEGG: hsa:652968

    STRING: 9606.ENSP00000384183

    UniGene: Hs.444950