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  4. Recombinant Human H (+)/Cl (-) exchange transporter 4 (CLCN4), partial

Recombinant Human H (+)/Cl (-) exchange transporter 4 (CLCN4), partial

  • 中文名稱：
    Recombinant Human H(+)/Cl(-) exchange transporter 4(CLCN4),partial
  • 貨號：
    CSB-YP005483HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human H(+)/Cl(-) exchange transporter 4(CLCN4),partial
  • 貨號：
    CSB-EP005483HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human H(+)/Cl(-) exchange transporter 4(CLCN4),partial
  • 貨號：
    CSB-EP005483HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human H(+)/Cl(-) exchange transporter 4(CLCN4),partial
  • 貨號：
    CSB-BP005483HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human H(+)/Cl(-) exchange transporter 4(CLCN4),partial
  • 貨號：
    CSB-MP005483HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CLCN4
  • Uniprot No.：
  • 別名：
    Chloride channel 4; Chloride channel protein 4; Chloride channel; voltage sensitive 4; Chloride transporter ClC-4; ClC 4A; ClC-4; CLC4; ClC4A; CLCN4; CLCN4_HUMAN; H(+)/Cl(-) exchange transporter 4; MGC163150
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.
  • 基因功能參考文獻：
    1. This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4, and ARHGEF15) not previously associated with epilepsies in humans. PMID: 23647072
    2. the voltage dependence of uncoupled ClC-4 by protons and anions PMID: 21354396
    3. CLCN4 is a novel driver of colon cancer progression. PMID: 20087350
    4. ClC-4 is an intracellular chloride channel that stimulates copper incorporation into ceruloplasmin, probably by improving the efficiency of the ATP7B copper pump. PMID: 15057754
    5. coupled Cl-/H+ transport of ClC-4 and ClC-5 is of significant magnitude in vivo PMID: 16034421
    6. crystal structure: CLIC4 appears to be able to form a redox-regulated ion channel in the absence of any partner proteins PMID: 16176272
    7. A stretch of amino acids, residues 14-63, at the N-terminus constitutes a novel motif both necessary and sufficient for targeting hClC-4 and other membrane proteins to the endoplasmic reticulum. PMID: 17023393
    8. The proposed mechanism results in anion-dependent conversion of ClC-type exchanger into an anion channel with typical attributes of ClC anion channels. PMID: 19364886
    9. Vesicle acidification, exocytosis, endocytosis, and secretory pathway. PMID: 10564087

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  • 相關(guān)疾?。?/div>
    Mental retardation, X-linked 49 (MRX49)
  • 亞細胞定位：
    Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Chloride channel (TC 2.A.49) family, ClC-4/CLCN4 subfamily
  • 組織特異性：
    Abundant in skeletal muscle and also detectable in brain and heart.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2022

    OMIM: 300114

    KEGG: hsa:1183

    STRING: 9606.ENSP00000370213

    UniGene: Hs.495674