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  4. CLCN4 Antibody

CLCN4 Antibody

  • 中文名稱：
    CLCN4兔多克隆抗體
  • 貨號：
    CSB-PA001674
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of RAT-MUSLE cells using CLC-4 Polyclonal Antibody
    • Western Blot analysis of NIH-3T3 cells using CLC-4 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CLCN4
  • 別名：
    Chloride channel 4 antibody; Chloride channel protein 4 antibody; Chloride channel; voltage sensitive 4 antibody; Chloride transporter ClC-4 antibody; ClC 4A antibody; ClC-4 antibody; CLC4 antibody; ClC4A antibody; CLCN4 antibody; CLCN4_HUMAN antibody; H(+)/Cl(-) exchange transporter 4 antibody; MGC163150 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CLC-4.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.
  • 基因功能參考文獻(xiàn)：
    1. This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4, and ARHGEF15) not previously associated with epilepsies in humans. PMID: 23647072
    2. the voltage dependence of uncoupled ClC-4 by protons and anions PMID: 21354396
    3. CLCN4 is a novel driver of colon cancer progression. PMID: 20087350
    4. ClC-4 is an intracellular chloride channel that stimulates copper incorporation into ceruloplasmin, probably by improving the efficiency of the ATP7B copper pump. PMID: 15057754
    5. coupled Cl-/H+ transport of ClC-4 and ClC-5 is of significant magnitude in vivo PMID: 16034421
    6. crystal structure: CLIC4 appears to be able to form a redox-regulated ion channel in the absence of any partner proteins PMID: 16176272
    7. A stretch of amino acids, residues 14-63, at the N-terminus constitutes a novel motif both necessary and sufficient for targeting hClC-4 and other membrane proteins to the endoplasmic reticulum. PMID: 17023393
    8. The proposed mechanism results in anion-dependent conversion of ClC-type exchanger into an anion channel with typical attributes of ClC anion channels. PMID: 19364886
    9. Vesicle acidification, exocytosis, endocytosis, and secretory pathway. PMID: 10564087

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  • 相關(guān)疾?。?/div>
    Mental retardation, X-linked 49 (MRX49)
  • 亞細(xì)胞定位：
    Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Chloride channel (TC 2.A.49) family, ClC-4/CLCN4 subfamily
  • 組織特異性：
    Abundant in skeletal muscle and also detectable in brain and heart.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2022

    OMIM: 300114

    KEGG: hsa:1183

    STRING: 9606.ENSP00000370213

    UniGene: Hs.495674