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CLCN4 Antibody

  • 中文名稱：
    CLCN4兔多克隆抗體
  • 貨號(hào)：
    CSB-PA968321
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from MCF-7 cells, using CLCN4 antibody.
    • Immunofluorescence analysis of HUVEC cells, using CLCN4 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CLCN4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CLCN4
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from internal of Human CLCN4.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC,IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:200
    IF 1:100-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.
  • 基因功能參考文獻(xiàn)：
    1. This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4, and ARHGEF15) not previously associated with epilepsies in humans. PMID: 23647072
    2. the voltage dependence of uncoupled ClC-4 by protons and anions PMID: 21354396
    3. CLCN4 is a novel driver of colon cancer progression. PMID: 20087350
    4. ClC-4 is an intracellular chloride channel that stimulates copper incorporation into ceruloplasmin, probably by improving the efficiency of the ATP7B copper pump. PMID: 15057754
    5. coupled Cl-/H+ transport of ClC-4 and ClC-5 is of significant magnitude in vivo PMID: 16034421
    6. crystal structure: CLIC4 appears to be able to form a redox-regulated ion channel in the absence of any partner proteins PMID: 16176272
    7. A stretch of amino acids, residues 14-63, at the N-terminus constitutes a novel motif both necessary and sufficient for targeting hClC-4 and other membrane proteins to the endoplasmic reticulum. PMID: 17023393
    8. The proposed mechanism results in anion-dependent conversion of ClC-type exchanger into an anion channel with typical attributes of ClC anion channels. PMID: 19364886
    9. Vesicle acidification, exocytosis, endocytosis, and secretory pathway. PMID: 10564087

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  • 相關(guān)疾病：
    Mental retardation, X-linked 49 (MRX49)
  • 亞細(xì)胞定位：
    Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Chloride channel (TC 2.A.49) family, ClC-4/CLCN4 subfamily
  • 組織特異性：
    Abundant in skeletal muscle and also detectable in brain and heart.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 2022

    OMIM: 300114

    KEGG: hsa:1183

    STRING: 9606.ENSP00000370213

    UniGene: Hs.495674