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  4. Recombinant Human Multimerin-2 (MMRN2), partial

Recombinant Human Multimerin-2 (MMRN2), partial

  • 中文名稱：
    人MMRN2重組蛋白
  • 貨號(hào)：
    CSB-YP880996HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MMRN2重組蛋白
  • 貨號(hào)：
    CSB-EP880996HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MMRN2重組蛋白
  • 貨號(hào)：
    CSB-EP880996HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MMRN2重組蛋白
  • 貨號(hào)：
    CSB-BP880996HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MMRN2重組蛋白
  • 貨號(hào)：
    CSB-MP880996HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MMRN2
  • Uniprot No.：
  • 別名：
    Elastin microfibril interface located protein 3; Elastin microfibril interfacer 3; EMILIN-3; EndoGlyx-1 p125/p140 subunit; MMRN2; MMRN2_HUMAN; Multimerin-2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.
  • 基因功能參考文獻(xiàn)：
    1. Results provide evidence identifying MMRN2 as a key molecule in regulating endothelial cell (EC) function and demonstrate that, during the angiogenic stimulation, its expression is controlled both transcriptionally and post-translationally by MMP9 for efficient EC sprouting. PMID: 28435016
    2. Data identify MMRN2 as a specific ligand for CD93. CD93 and MMRN2 are co-expressed in the blood vessels of various tumors. Moreover, disruption of the CD93-MMRN2 interaction reduced endothelial cell adhesion and migration. Site-directed mutagenesis identified different residue hotspots either directly or indirectly involved in the binding and propose a molecular model in which the coiled-coil domain of MMRN2 is engaged. PMID: 28912033
    3. Results suggest that CLEC14A-MMRN2 binding has a role in inducing sprouting angiogenesis during tumor growth, which has the potential to be manipulated in future antiangiogenic therapy design. PMID: 25745997
    4. CLEC14A is a matrix component which binds to MMRN2 in the process of endothelial cells transformation in tumor angiogenesis. PMID: 23979707
  • 亞細(xì)胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 組織特異性：
    Endothelium.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 19888

    OMIM: 608925

    KEGG: hsa:79812

    STRING: 9606.ENSP00000361097

    UniGene: Hs.524479