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  4. Recombinant Human Protein ACN9 homolog, mitochondrial (ACN9)

Recombinant Human Protein ACN9 homolog, mitochondrial (ACN9)

  • 中文名稱：
    人SDHAF3重組蛋白
  • 貨號：
    CSB-YP885709HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SDHAF3重組蛋白
  • 貨號：
    CSB-EP885709HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SDHAF3重組蛋白
  • 貨號：
    CSB-EP885709HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SDHAF3重組蛋白
  • 貨號：
    CSB-BP885709HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SDHAF3重組蛋白
  • 貨號：
    CSB-MP885709HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SDHAF3
  • Uniprot No.：
  • 別名：
    SDHAF3; ACN9; DC11Succinate dehydrogenase assembly factor 3; mitochondrial; SDH assembly factor 3; SDHAF3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    31-125
  • 氨基酸序列
    GDQYVKDEFR RHKTVGSDEA QRFLQEWEVY ATALLQQANE NRQNSTGKAC FGTFLPEEKL NDFRDEQIGQ LQELMQEATK PNRQFSISES MKPKF
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.
  • 基因功能參考文獻(xiàn)：
    1. SDHAF3 interacts directly with SDHB (residue 242 being key to this interaction), and that a variant in SDHAF3 (c.157 T > C [p.Phe53Leu]) may be more prevalent in individuals with familial and sporadic pheochromocytoma and paraganglioma, and is hypomorphic via impaired interaction with SDHB. PMID: 28738844
    2. Single nucleotide polymorphism in ACN9 gene is associated with alcohol dependence. PMID: 25821040
    3. ACN9 is involved in the predisposition to alcohol dependence. PMID: 18163977
  • 亞細(xì)胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Complex I LYR family, SDHAF3 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 21752

    OMIM: 615773

    KEGG: hsa:57001

    STRING: 9606.ENSP00000414066

    UniGene: Hs.592269