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ULBP1 Recombinant Monoclonal Antibody

  • 中文名稱：
    ULBP1重組抗體
  • 貨號(hào)：
    CSB-RA446786A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, Raji whole cell lysate, HEK293 whole cell lysate
      All lanes: ULBP1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 28 kDa
      Observed band size: 36-50 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    ULBP1重組單克隆抗體（CUSABIO貨號(hào)：CSB-RA446786A0HU）是針對(duì)ULBP1蛋白設(shè)計(jì)的高特異性科研工具，該靶點(diǎn)為自然殺傷細(xì)胞活化性受體NKG2D的關(guān)鍵配體，廣泛參與腫瘤免疫監(jiān)視及感染性疾病中的天然免疫應(yīng)答調(diào)控。本抗體經(jīng)嚴(yán)格驗(yàn)證適用于ELISA和WB等檢測(cè)方法，在Western Blot實(shí)驗(yàn)中推薦使用1:500至1:2000的稀釋范圍，可穩(wěn)定識(shí)別目標(biāo)蛋白并呈現(xiàn)清晰的特異性條帶，實(shí)驗(yàn)結(jié)果顯示其具有優(yōu)異的批間一致性和低交叉反應(yīng)特性。該產(chǎn)品適用于腫瘤微環(huán)境研究、免疫細(xì)胞活化機(jī)制解析、病毒感染相關(guān)免疫逃逸等基礎(chǔ)科研領(lǐng)域，特別在探索NK細(xì)胞功能調(diào)控、腫瘤免疫逃逸機(jī)制或免疫治療靶點(diǎn)篩選等實(shí)驗(yàn)中展現(xiàn)重要應(yīng)用價(jià)值，為體外細(xì)胞實(shí)驗(yàn)、蛋白互作研究及病理模型分析提供可靠工具。
  • Uniprot No.：
  • 基因名：
  • 別名：
    UL16-binding protein 1 (ALCAN-beta) (NKG2D ligand 1) (N2DL-1) (NKG2DL1) (Retinoic acid early transcript 1I), ULBP1, N2DL1 RAET1I
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human ULBP1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    13C8
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
  • 基因功能參考文獻(xiàn)：
    1. we show that Simian Virus 40 (SV40)...evades NK cell attack through the down regulation of...ULBP1 PMID: 26992229
    2. ATF4 drives ULBP1 gene expression in cancer cell lines, while the RNA-binding protein RBM4 supports ULBP1 expression by suppressing a novel alternatively spliced isoform of ULBP1 mRNA. PMID: 26565589
    3. expression determines intrinsic acute myeloid leukemia susceptibility to allogeneic V[gamma]9V[delta]2 T cells PMID: 24911793
    4. recurrence-free survival of patients with ULBP1-negative hepatocellular carcinoma (HCC) was significantly shorter than that of patients with ULBP1-positive HCC PMID: 21756848
    5. recombinant ULBP1 fused to CD45 caused a reduction in cytotoxicity and degranulation by NK cells, implying a role for receptor ligand distribution in the activation of NK cell responses PMID: 21464092
    6. Data show that ULBP1, TFR2 and IFITM1 were associated with increased susceptibility to Vgamma9Vdelta2 T-cell cytotoxicity. PMID: 20220060
    7. These results identify Mult1 as a target for the MARCH family of E3 ligases PMID: 20870941
    8. As NKG2D ligand, ULBP1 are expressed on immature dendritic cells and plays an important role in the cytotoxic effect of NK cells against iDC. PMID: 18394338
    9. Data show that the protease NS3/4A of HCV down-regulates ULBP1 expression by inhibiting the transcription of ULBP1. PMID: 19500498
    10. ULBP1 binds to the NKG2D receptor and activates multiple signaling pathways in primary natural killer cells. PMID: 11777960
    11. The NKG2D ligand ULBP1 is up-regulated and readily detectable intracellularly in the endoplasmic reticulum of human cytomegalovirus-infected fibroblasts, where it colocalizes with viral protein UL16. PMID: 12847260
    12. ULBP1 is a human ligand of the NKG2D receptor PMID: 16901903
    13. The selective induction of ULBP1 expression by proteasome inhibitor drugs, along with variable NKG2D ligand expression by human tumor cells, indicates that NKG2D ligand genes are independently regulated. PMID: 19414815

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  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum.
  • 蛋白家族：
    MHC class I family
  • 組織特異性：
    Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 14893

    OMIM: 605697

    KEGG: hsa:80329

    STRING: 9606.ENSP00000229708

    UniGene: Hs.653255