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  4. Recombinant Human Mitochondrial folate transporter/carrier (SLC25A32)

Recombinant Human Mitochondrial folate transporter/carrier (SLC25A32)

  • 中文名稱：
    人SLC25A32重組蛋白
  • 貨號：
    CSB-CF872477HU
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    SLC25A32
  • Uniprot No.：
  • 別名：
    SLC25A32; MFT; MFTC; Mitochondrial folate transporter/carrier; Solute carrier family 25 member 32
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-315
  • 氨基酸序列
    MTGQGQSASGSSAWSTVFRHVRYENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRP KYNGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEA TEYLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVR GLYKGFVPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVA ATYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVY ENVSHFLLDLREKRK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Transports folate across the inner membranes of mitochondria. Can also transport FAD across the mitochondrial inner membrane.
  • 基因功能參考文獻(xiàn)：
    1. These data demonstrate that the loss of functional Slc25a32 results in cranial neural tube defects (NTDs) in mice and has also been observed in a human NTD patient. PMID: 29666258
    2. A novel SLC25A32 homozygous variant is associated with severe neuromuscular phenotype. PMID: 28443623
    3. SLC25A32 gene polymorphism could be a risk factor for lower folate concentration and future fracture. PMID: 24354357
    4. identified residues in the walls and at the base of the transport cavity that are involved in substrate recognition by the MFT PMID: 21768094
    5. Patient with SLC25A32 deficiency was able to have a successful pregnancy after fertilization in vitro. PMID: 19362304

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  • 相關(guān)疾?。?/div>
    Exercise intolerance, riboflavin-responsive (RREI)
  • 亞細(xì)胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Mitochondrial carrier (TC 2.A.29) family
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29683

    OMIM: 610815

    KEGG: hsa:81034

    STRING: 9606.ENSP00000297578

    UniGene: Hs.532265