搡老女人多毛老妇女中国,日韩亚洲欧美中文高清在线,人妻少妇一区二区三区,色妞色综合久久夜夜,日本熟妇xxxx

CD14

CD14蛋白全稱(chēng)為單核細(xì)胞分化抗原CD14,也被稱(chēng)作MY23、LeuM3或p55,是一種錨定在細(xì)胞膜表面的糖蛋白,主要分布于單核細(xì)胞、巨噬細(xì)胞及中性粒細(xì)胞表面。CD14作為脂多糖(LPS)的高親和力受體,能夠識(shí)別并結(jié)合細(xì)菌內(nèi)毒素,通過(guò)與TLR4受體形成復(fù)合物激活下游免疫應(yīng)答。在感染過(guò)程中,CD14通過(guò)TLR4/MyD88依賴(lài)的信號(hào)通路觸發(fā)NF-κB等轉(zhuǎn)錄因子活化,誘導(dǎo)TNF-α、IL-6等促炎因子釋放,參與膿毒癥、慢性炎癥性疾病的發(fā)展。臨床研究發(fā)現(xiàn),CD14基因多態(tài)性與動(dòng)脈粥樣硬化、阿爾茨海默病及類(lèi)風(fēng)濕性關(guān)節(jié)炎等疾病風(fēng)險(xiǎn)相關(guān),其表達(dá)水平在膿毒癥患者血液中顯著升高,已成為感染性休克的潛在生物標(biāo)志物。針對(duì)CD14的抗體藥物(如IC14)已進(jìn)入臨床試驗(yàn)階段,用于中和內(nèi)毒素引發(fā)的過(guò)度炎癥反應(yīng),同時(shí)基于TLR4-CD14信號(hào)軸的小分子抑制劑也在探索治療自身免疫性疾病的新策略。

熱銷(xiāo)產(chǎn)品

Recombinant Human Monocyte differentiation antigen CD14 (CD14) (CSB-MP004879HU)

驗(yàn)證數(shù)據(jù)

CSB-MP004879HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CD14 Recombinant Monoclonal Antibody (CSB-RA004879MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA004879MA1HU

IHC image of CSB-RA004879MA1HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA004879MA1HU

The Binding Activity of Human CD14 with Anti-CD14 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD14 (CSB-MP004879HU1) at 2 μg/mL on an Nickel Coated plate can bind Anti-CD14 recombinant antibody. The EC50 is 2.148-2.447 ng/mL.

CD14 Antibodies

CD14 for Homo sapiens (Human)

CD14 Proteins

CD14 Proteins for Mus musculus (Mouse)

CD14 Proteins for Homo sapiens (Human)

CD14 Proteins for Oryctolagus cuniculus (Rabbit)

CD14 Proteins for Rattus norvegicus (Rat)

CD14 Proteins for Bos taurus (Bovine)

CD14 ELISA Kit

CD14 ELISA Kit for Homo sapiens (Human)

CD14 ELISA Kit for Rattus norvegicus (Rat)