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EIF4E

EIF4E,即真核翻譯起始因子4E,別名eIF4E,是mRNA翻譯的關(guān)鍵調(diào)控者,源自真核生物細(xì)胞。它通過綁定mRNA的5'端帽子結(jié)構(gòu),引領(lǐng)翻譯機(jī)器到達(dá)mRNA的起始點(diǎn),解鎖mRNA,使之能與核糖體結(jié)合,啟動(dòng)蛋白質(zhì)合成。EIF4E不僅調(diào)控基因表達(dá)的速度與程度,還參與mRNA穩(wěn)定性、轉(zhuǎn)運(yùn)與降解等多個(gè)細(xì)胞過程。在生物學(xué)上,EIF4E的異常調(diào)控與多種疾病相關(guān),特別是其高表達(dá)常被發(fā)現(xiàn)于腫瘤中,成為腫瘤增殖與抗藥性的關(guān)鍵因素。因此,EIF4E成為抗癌療法的新靶點(diǎn),具有重要的研究與應(yīng)用價(jià)值。

熱銷產(chǎn)品

Phospho-EIF4E (S209) Recombinant Monoclonal Antibody (CSB-RA007556A209phHU)

驗(yàn)證數(shù)據(jù)

CSB-RA007556A209phHU

Western Blot
Positive WB detected in 293 whole cell lysate,HepG2 whole cell lysate(treated with Calyculin A or not)
All lanes Phospho-EIF4E antibody at 1.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 25 KDa
Observed band size: 25 KDa

CSB-RA007556A209phHU

IHC image of CSB-RA007556A209phHU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

EIF4E Antibodies

EIF4E for Homo sapiens (Human)

EIF4E Proteins

EIF4E Proteins for Oryctolagus cuniculus (Rabbit)

EIF4E Proteins for Mus musculus (Mouse)

EIF4E Proteins for Homo sapiens (Human)

EIF4E Proteins for Xenopus laevis (African clawed frog)

EIF4E Proteins for Rattus norvegicus (Rat)

EIF4E Proteins for Dictyostelium discoideum (Slime mold)

EIF4E Proteins for Bos taurus (Bovine)