SAE1
SAE1，全名為SUMO-激活酶亞基1，也被稱為SUMO-1激活酶E1亞基。它是一種參與蛋白質(zhì)翻譯后修飾的重要蛋白，通過(guò)添加小蛋白SUMO（SUMO1）或sumoylation來(lái)調(diào)節(jié)蛋白質(zhì)的結(jié)構(gòu)和細(xì)胞內(nèi)定位。SAE1與UBA2蛋白形成一個(gè)異二聚體，作為SUMO激活酶，在蛋白質(zhì)的SUMO化過(guò)程中發(fā)揮關(guān)鍵作用。SAE1蛋白與多種疾病相關(guān)，包括奧格登綜合征、成人皮肌炎、肌炎等。在藥物研發(fā)方面，針對(duì)SAE1蛋白的藥物研究正在進(jìn)展中，旨在開(kāi)發(fā)新的治療方法來(lái)治療與SAE1相關(guān)的疾病。
熱銷(xiāo)產(chǎn)品
Recombinant Human SUMO-activating enzyme subunit 1 (SAE1) (CSB-EP883359HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SAE1 Recombinant Monoclonal Antibody (CSB-RA987582A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: K562 whole cell lysate
All lanes: SAE1 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 39, 30, 34 kDa
Observed band size: 39 kDa
Immunofluorescence staining of Hela Cells with CSB-RA987582A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
SAE1 Antibodies
SAE1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA020666GA01HU | SAE1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA794022 | SAE1 Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA004045 | SAE1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA897667 | SAE1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA493084 | SAE1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA883359ESR2HU | SAE1 Antibody | Human | ELISA, IHC |
| CSB-RA987582A0HU | SAE1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IF |
SAE1 Proteins
SAE1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP020666BO CSB-EP020666BO CSB-BP020666BO CSB-MP020666BO CSB-EP020666BO-B |
Recombinant Bovine SUMO-activating enzyme subunit 1 (SAE1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SAE1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP638966XBF CSB-EP638966XBF CSB-BP638966XBF CSB-MP638966XBF CSB-EP638966XBF-B |
Recombinant Xenopus tropicalis SUMO-activating enzyme subunit 1 (sae1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SAE1 Proteins for Dictyostelium discoideum (Slime mold)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP706892DKK CSB-EP706892DKK CSB-BP706892DKK CSB-MP706892DKK CSB-EP706892DKK-B |
Recombinant Dictyostelium discoideum SUMO-activating enzyme subunit 1 (sae1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SAE1 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP708923PYX CSB-EP708923PYX CSB-BP708923PYX CSB-MP708923PYX CSB-EP708923PYX-B |
Recombinant Pongo abelii SUMO-activating enzyme subunit 1 (SAE1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SAE1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP738122RA CSB-EP738122RA CSB-BP738122RA CSB-MP738122RA CSB-EP738122RA-B |
Recombinant Rat SUMO-activating enzyme subunit 1 (Sae1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SAE1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP746933DIL CSB-EP746933DIL CSB-BP746933DIL CSB-MP746933DIL CSB-EP746933DIL-B |
Recombinant Danio rerio SUMO-activating enzyme subunit 1 (sae1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SAE1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP809048XBE CSB-EP809048XBE CSB-BP809048XBE CSB-MP809048XBE CSB-EP809048XBE-B |
Recombinant Xenopus laevis SUMO-activating enzyme subunit 1 (sae1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SAE1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP865647MO CSB-EP865647MO CSB-BP865647MO CSB-MP865647MO CSB-EP865647MO-B |
Recombinant Mouse SUMO-activating enzyme subunit 1 (Sae1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SAE1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP883359HU CSB-BP883359HU CSB-MP883359HU CSB-EP883359HU-B |
Recombinant Human SUMO-activating enzyme subunit 1 (SAE1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP883359HU | Recombinant Human SUMO-activating enzyme subunit 1 (SAE1) | E.coli |
