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SAE1 Antibody

  • 中文名稱：
    SAE1兔多克隆抗體
  • 貨號：
    CSB-PA883359ESR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA883359ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA883359ESR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SAE1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Activator of SUMO1 antibody; AOS1 antibody; HSPC140 antibody; Sae1 antibody; SAE1_HUMAN antibody; Sentrin/SUMO activating protein AOS1 antibody; SUA1 antibody; SUMO 1 activating enzyme E1 N subunit antibody; SUMO 1 activating enzyme subunit 1 antibody; SUMO-activating enzyme subunit 1 antibody; Ubiquitin like protein SUMO1 activating enzyme antibody; Ubiquitin-like 1-activating enzyme E1A antibody; UBL E1A antibody; UBLE1A antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human SUMO-activating enzyme subunit 1 protein (1-346AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
  • 基因功能參考文獻：
    1. the expression of SENP8, SAE1, PIAS1, PIAS2 and ZMIZ1 is deregulated in the majority of PTC tissues, likely contributing to the PTC phenotype. PMID: 26403403
    2. as it has been shown by flow cytometry analysis, specific knockdown of SAE1 slowed down the cell population at G0/G1 phase and induced apoptosis of RKO cells. PMID: 25842831
    3. SUMO-1 controls the protein stability and the biological function of phosducin. PMID: 16421094
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Ubiquitin-activating E1 family
  • 組織特異性：
    Expression level increases during S phase and drops in G2 phase (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30660

    OMIM: 613294

    KEGG: hsa:10055

    STRING: 9606.ENSP00000270225

    UniGene: Hs.515500