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TMEM176B

TMEM176B,全稱Transmembrane Protein 176B,是一種跨膜蛋白,也被稱為L(zhǎng)R8或MS4B2。研究表明,TMEM176B在多種癌癥中高表達(dá),且與患者較短的無病生存期相關(guān)。在卵巢癌中,TMEM176B通過抑制Wnt/β-catenin信號(hào)通路的激活來抑制EMT,進(jìn)而阻礙卵巢癌的進(jìn)展。此外,TMEM176B還在其他疾病中發(fā)揮作用,例如在家族性tau蛋白病中,TMEM176B的表達(dá)水平降低,這表明TMEM176B可能參與tau蛋白病相關(guān)的免疫反應(yīng)?;谶@些發(fā)現(xiàn),TMEM176B有望成為多種癌癥的診斷和預(yù)后評(píng)估的生物標(biāo)志物,以及治療的新靶點(diǎn)。目前,針對(duì)TMEM176B的藥物研發(fā)尚處于起步階段,未來需要更多的研究來探索其潛在的應(yīng)用價(jià)值。

熱銷產(chǎn)品

TMEM176B Antibody (CSB-PA023758LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA023758LA01HU

Western Blot
Positive WB detected in: THP-1 whole cell lysate(30μg), SY5Y whole cell lysate(30μg), Hela whole cell lysate(30μg), K562 whole cell lysate(30μg)
All lanes: TMEM176B antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 30,26 kDa
Observed band size: 30 kDa
Exposure time:120s

CSB-PA023758LA01HU

Immunofluorescence staining of Hela cell with CSB-PA023758LA01HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and and permeated by 0.2% TritonX-100 for 15 min. Then 10% normal goat serum to block non-specific protein-protein interactions . The cells were then incubated with the antibody overnight at 4℃. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA023758LA01HU

Immunofluorescence staining of Hela cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

TMEM176B Antibodies

TMEM176B for Homo sapiens (Human)

TMEM176B Proteins

TMEM176B Proteins for Homo sapiens (Human)