IL6
IL-6（白細胞介素-6）是一種糖蛋白，由184個氨基酸殘基組成，分子量約為21~26 kDa。它包含四個半胱氨酸殘基，形成兩個分子內(nèi)二硫鍵，這使得IL-6的結(jié)構(gòu)穩(wěn)定。IL-6的分泌形式可以是游離的，也可以與可溶性IL-6受體（sIL-6R）結(jié)合形成復(fù)合物。IL-6具有多種生物學(xué)功能，包括但不限于：免疫調(diào)節(jié)、炎癥反應(yīng)、造血作用：IL-6可以促進骨髓造血干細胞的增殖和分化，參與紅細胞、血小板等血液成分的生成。IL-6與多種疾病的發(fā)生和發(fā)展密切相關(guān)，如風濕性關(guān)節(jié)炎、多發(fā)性硬化癥、糖尿病、心血管疾病以及某些類型的腫瘤等。 IL-6的信號傳導(dǎo)主要通過以下兩種途徑實現(xiàn)：經(jīng)典信號通路：IL-6首先與膜結(jié)合的IL-6受體（mIL-6R）結(jié)合，然后招募并激活gp130分子（一個信號轉(zhuǎn)導(dǎo)蛋白）。激活的gp130觸發(fā)JAK（Janus激酶）的磷酸化，進而激活STAT3（信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子3）?；罨腟TAT3進入細胞核，調(diào)控基因表達。反式信號通路：在缺乏mIL-6R的細胞上，IL-6可以與sIL-6R結(jié)合，形成IL-6/sIL-6R復(fù)合物。這個復(fù)合物隨后與細胞表面的gp130結(jié)合并激活信號通路。這種反式信號通路使得IL-6能夠在更廣泛的細胞類型中發(fā)揮作用。異常的IL-6表達和信號傳導(dǎo)可能導(dǎo)致疾病的發(fā)生和發(fā)展。因此，對IL-6的深入研究有助于我們更好地理解其在疾病中的作用，并為疾病的治療提供新的思路和方法。
熱銷產(chǎn)品
Recombinant Human Interleukin-6 (IL6) (Active) (CSB-YP011664HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 58 - 295 pg/mL.
IL6 (Siltuximab) Recombinant Monoclonal Antibody (CSB-RA011664MA1HU)
驗證數(shù)據(jù)
The Binding Activity of Human IL6 with Anti-IL6 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IL6 (CSB-YP011664HU) at 2 μg/mL can bind Anti-IL6 recombinant antibody. The EC50 is 35.80-41.82 ng/mL.
Human Interleukin 6,IL-6 ELISA KIT (CSB-E04638h)
驗證數(shù)據(jù)
貨號：CSB-E04638h
規(guī)格：96T/48T
靈敏度：2.453 pg/mL
檢測范圍：7.8 pg/mL-500 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
IL6 Antibodies
IL6 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA06757B0Rb | IL6 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA06757C0Rb | IL6 Antibody, FITC conjugated | Human | |
| CSB-PA06757A0Rb | IL6 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA06757D0Rb | IL6 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA005546 | IL6 Antibody | Human | WB, ELISA |
| CSB-RA011664MA1HU | IL6 (Siltuximab) Recombinant Monoclonal Antibody | Human | ELISA |
| CSB-RA011664MA2HU | IL6 (sirukumab) Recombinant Monoclonal Antibody | Human | ELISA, IHC |
IL6 Proteins
IL6 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011664BO CSB-BP011664BO CSB-MP011664BO CSB-EP011664BO-B |
Recombinant Bovine Interleukin-6 (IL6) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011664DO CSB-EP011664DO CSB-BP011664DO CSB-MP011664DO CSB-EP011664DO-B |
Recombinant Dog Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011664PI CSB-EP011664PI CSB-BP011664PI CSB-MP011664PI CSB-EP011664PI-B |
Recombinant Pig Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011664SH | Recombinant Sheep Interleukin-6 (IL6) | Yeast |
| CSB-EP011664SH | Recombinant Sheep Interleukin-6 (IL6) | E.coli |
| CSB-BP011664SH CSB-MP011664SH CSB-EP011664SH-B |
Recombinant Sheep Interleukin-6 (IL6) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011664CA CSB-EP011664CA CSB-BP011664CA CSB-MP011664CA CSB-EP011664CA-B |
Recombinant Cat Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011664MOW CSB-EP011664MOW CSB-BP011664MOW CSB-MP011664MOW CSB-EP011664MOW-B |
Recombinant Macaca mulatta (Rhesus macaque) Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP003101MOW | Recombinant Macaca mulatta Interleukin-6 protein (IL6) | E.Coli |
IL6 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP011664HU CSB-MP011664HU CSB-EP011664HU-B |
Recombinant Human Interleukin-6 (IL6) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP001741HU | Recombinant Human Interleukin-6 protein (IL6) | E.Coli |
| CSB-EP011664HU | Recombinant Human Interleukin-6 (IL6) (Active) | E.coli |
| CSB-AP004301HU | Recombinant Human Interleukin-6 (IL6) (Active) | E.coli |
| CSB-AP005841HU | Recombinant Human Interleukin-6 (IL6) (Active) (GMP) | E.Coli |
| CSB-YP011664HU | Recombinant Human Interleukin-6 (IL6) (Active) | Yeast |
| CSB-MP011664HU-B | Recombinant Human Interleukin-6 (IL6), Biotinylated | Mammalian cell |
| CSB-EP011664HUe1 | Recombinant Human Interleukin-6 (IL6) | E.coli |
| CSB-MP011664HU-WD | Recombinant Human Interleukin-6 (IL6) (Active) | Mammalian cell |
IL6 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011664MO CSB-EP011664MO CSB-BP011664MO CSB-MP011664MO CSB-EP011664MO-B |
Recombinant Mouse Interleukin-6 (Il6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP003321MO | Recombinant Mouse Interleukin-6 protein (Il6) (Active) | E.Coli |
IL6 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP305249MOV CSB-EP305249MOV CSB-BP305249MOV CSB-EP305249MOV-B |
Recombinant Macaca fascicularis Interleukin-6 (IL6) | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
IL6 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP322670RA CSB-EP322670RA CSB-BP322670RA CSB-MP322670RA CSB-EP322670RA-B |
Recombinant Rat Interleukin-6 (Il6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Mustela vison (American mink) (Neovison vison)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP336891MVE CSB-EP336891MVE CSB-BP336891MVE CSB-MP336891MVE CSB-EP336891MVE-B |
Recombinant Mustela vison Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP342020DRI CSB-EP342020DRI CSB-BP342020DRI CSB-MP342020DRI CSB-EP342020DRI-B |
Recombinant Cercocebus atys Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Mustela putorius furo (European domestic ferret) (Mustela furo)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP385261MOH CSB-EP385261MOH CSB-BP385261MOH CSB-MP385261MOH CSB-EP385261MOH-B |
Recombinant Mustela putorius furo Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Sparus aurata (Gilthead sea bream)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP466936FJX CSB-EP466936FJX CSB-BP466936FJX CSB-MP466936FJX CSB-EP466936FJX-B |
Recombinant Sparus aurata Interleukin-6 (il6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Marmota monax (Woodchuck)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP518577MQG CSB-EP518577MQG CSB-BP518577MQG CSB-MP518577MQG CSB-EP518577MQG-B |
Recombinant Marmota monax Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP610956OEI CSB-EP610956OEI CSB-BP610956OEI CSB-MP610956OEI CSB-EP610956OEI-B |
Recombinant Oncorhynchus mykiss Interleukin-6 (il6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Orcinus orca (Killer whale)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP630696OEP CSB-EP630696OEP CSB-BP630696OEP CSB-MP630696OEP CSB-EP630696OEP-B |
Recombinant Orcinus orca Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Capra hircus (Goat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP631708GO CSB-EP631708GO CSB-BP631708GO CSB-MP631708GO CSB-EP631708GO-B |
Recombinant Goat Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Phoca vitulina (Harbor seal)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP631730EUR CSB-EP631730EUR CSB-BP631730EUR CSB-MP631730EUR CSB-EP631730EUR-B |
Recombinant Phoca vitulina Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Vulpes vulpes (Red fox)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP635622VFW CSB-EP635622VFW CSB-BP635622VFW CSB-MP635622VFW CSB-EP635622VFW-B |
Recombinant Vulpes vulpes Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Bubalus carabanensis (Swamp type water buffalo) (Bubalus bubalis carabanensis)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP640800BAAW CSB-EP640800BAAW CSB-BP640800BAAW CSB-MP640800BAAW CSB-EP640800BAAW-B |
Recombinant Bubalus carabanensis Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Macaca thibetana (Pere David's macaque) (Tibetan macaque)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP686313MDAO CSB-EP686313MDAO CSB-BP686313MDAO CSB-MP686313MDAO CSB-EP686313MDAO-B |
Recombinant Macaca thibetana Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Bubalus bubalis (Domestic water buffalo)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP740930BWX CSB-EP740930BWX CSB-BP740930BWX CSB-MP740930BWX CSB-EP740930BWX-B |
Recombinant Bubalus bubalis Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP760907TKY CSB-EP760907TKY CSB-BP760907TKY CSB-MP760907TKY CSB-EP760907TKY-B |
Recombinant Takifugu rubripes Interleukin-6 (il6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Camelus bactrianus (Bactrian camel)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP772948CVZ CSB-EP772948CVZ CSB-BP772948CVZ CSB-MP772948CVZ CSB-EP772948CVZ-B |
Recombinant Camelus bactrianus Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Lama glama (Llama)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP803040LBS CSB-BP803040LBS CSB-EP803040LBS-B |
Recombinant Lama glama Interleukin-6 (IL6) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
IL6 Proteins for Saimiri sciureus (Common squirrel monkey)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP847583SWD CSB-EP847583SWD CSB-BP847583SWD CSB-MP847583SWD CSB-EP847583SWD-B |
Recombinant Saimiri sciureus Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP856206CH CSB-EP856206CH CSB-BP856206CH CSB-MP856206CH CSB-EP856206CH-B |
Recombinant Chicken Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Equus caballus (Horse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP856767HO CSB-EP856767HO CSB-BP856767HO CSB-MP856767HO CSB-EP856767HO-B |
Recombinant Horse Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP863071RB | Recombinant Rabbit Interleukin-6 (IL6) | Yeast |
| CSB-EP863071RB CSB-BP863071RB CSB-MP863071RB CSB-EP863071RB-B |
Recombinant Rabbit Interleukin-6 (IL6) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 Proteins for Delphinapterus leucas (Beluga whale)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP893174DJB CSB-EP893174DJB CSB-BP893174DJB CSB-MP893174DJB CSB-EP893174DJB-B |
Recombinant Delphinapterus leucas Interleukin-6 (IL6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL6 ELISA Kit
IL6 ELISA Kit for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12899B | Bovine Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 2.5 pg/mL |
IL6 ELISA Kit for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08549Ch | Chicken Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
IL6 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11260c | Dog Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 0.39 pg/mL |
IL6 ELISA Kit for Capra hircus (Goat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14360G | Goat Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 0.39 pg/mL |
IL6 ELISA Kit for Monkey
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E10050Mo | Monkey Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
IL6 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04639m | Mouse Interleukin 6,IL-6 ELISA KIT |
IL6 ELISA Kit for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E06786p | Pig Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 0.31 pg/mL |
IL6 ELISA Kit for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E06903Rb | Rabbit Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
IL6 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04640r | Rat Interleukin 6,IL-6 ELISA KIT | serum, plasma, tissue homogenates | 0.078 pg/ml |
IL6 ELISA Kit for Ovis aries (Sheep)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E10116Sh | Sheep Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 2 pg/mL |
IL6 ELISA Kit for Fish
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13258Fh | Fish Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 12.5 pg/mL |
IL6 ELISA Kit for Equus caballus (Horse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E16634Hs | Horse Interleukin 6(IL-6)ELISA Kit | serum, plasma, tissue homogenates | 0.78 pg/mL |
IL6 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04638h | Human Interleukin 6,IL-6 ELISA KIT | serum, plasma, cell culture supernates, tissue homogenates, urine | 2.453 pg/mL |
| CSB-E04638h-IS | Human Interleukin 6,IL-6 ELISA KIT | serum, plasma, cell culture supernates, tissue homogenates, saliva, urine | 2.35pg/mL |
