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自身免疫疾病系列——

干燥綜合征

干燥綜合征

干燥綜合征(Sj?gren's syndrome, SS)是一種慢性自身免疫性結(jié)締組織疾病,主要由遺傳、內(nèi)分泌、病毒感染等多種因素引發(fā),導(dǎo)致唾液腺、淚腺等外分泌腺功能受損,臨床表現(xiàn)為口干、眼干、皮膚干燥、關(guān)節(jié)疼痛、消化系統(tǒng)及呼吸系統(tǒng)等多系統(tǒng)受累癥狀。干燥綜合征可以分為原發(fā)性和繼發(fā)性兩種類型。原發(fā)性干燥綜合征(pSS)是指不伴有其他自身免疫性疾病的情況,而繼發(fā)性干燥綜合征則是與其他自身免疫性疾病如類風(fēng)濕關(guān)節(jié)炎或系統(tǒng)性紅斑狼瘡等并發(fā)的情況。

干燥綜合征的藥物研發(fā)主要集中在以下幾個方向:

  • B細胞靶向療法:由于干燥綜合征是一種表現(xiàn)為B細胞高度活躍的疾病,B細胞亞群的異常在疾病的發(fā)生發(fā)展中可能扮演關(guān)鍵的角色,因此靶向B細胞的治療策略備受關(guān)注。目前研究的主要藥物包括靶向B細胞表面CD20的利妥昔單抗、靶向BAFF-R的單抗藥物Ianalumab,以及我國自主研發(fā)的1.1類新藥艾拉莫德(IGU),這些藥物均針對B細胞的存活或功能進行抑制。
  • FcRn單抗療法:Nipocalimab是一種抗新生兒Fc受體(FcRn)的單克隆抗體,通過選擇性阻斷IgG與FcRn的相互作用以降低包括自身抗體在內(nèi)的循環(huán)IgG水平,從而改善干燥綜合征患者的病情。這一療法的有效性已在臨床II期研究中得到驗證。
  • CD40L拮抗劑:Dazodalibep是一種非抗體融合蛋白,可作為CD40L拮抗劑,阻斷T細胞、B細胞和抗原呈遞細胞之間的協(xié)同刺激信號,從而降低與B細胞、T細胞和樹突狀細胞生物標志物相關(guān)的多種蛋白質(zhì)在干燥綜合征患者中的水平。
  • TYK2抑制劑:氘可來昔替尼(BMS-986165)是一種高效選擇性的TYK2變構(gòu)抑制劑,可靶向作用于干燥綜合征相關(guān)細胞因子(包括I型IFN、白介素-12和白介素-23),通過阻斷這些通路的信號傳導(dǎo)來發(fā)揮作用,該藥物已在2023年批準上市。

其他如CD19、CD22、IL2R、IL17R等也是干燥綜合征藥物研發(fā)的重要靶點。針對這些靶點的藥物也在臨床研發(fā)中,并顯示出一定的療效。

華美生物長期致力于為科研工作者提供高質(zhì)量的蛋白、抗體、ELISA試劑盒等工具類科研試劑產(chǎn)品,特整理了一系列與干燥綜合征研究相關(guān)的熱門靶點及相關(guān)試劑產(chǎn)品列舉如下,供您選擇:

干燥綜合征藥物靶點相關(guān)產(chǎn)品推薦

● 靶點蛋白

CSB-MP004900HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.

CSB-MP004936HU1 Activity Verified

Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.

CSB-MP004937HU3 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD40L at 2 μg/ml can bind Anti- CD40L Rabbit Monoclonal Antibody(CSB-RA156386A0HU), the EC50 is 2.353-3.232 ng/ml.

CSB-MP010958HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized ICOSLG at 2 μg/ml can bind human ICOS (CSB-MP707478HU), the EC50 of human ICOSLG protein is 29.04-43.59 ng/ml

MS4A1(CD20)
CSB-MP015007HU
CSB-MP015007HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP853495HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B (CSB-MP897523HU1) at 2 μg/ml can bind TNFRSF13C, the EC50 is 9.943-15.72 ng/ml

CSB-MP897523HU1 Activity Verified

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

Target Product Name Source Tag Info Product Code
CD22 Recombinant Human B-cell receptor CD22 (CD22), partial E.coli N-terminal 6xHis-SUMO-tagged CSB-EP004900HU1
CD22 Recombinant Human B-cell receptor CD22 (CD22), partial (Active) Mammalian cell C-terminal 6xHis-tagged CSB-MP004900HU
CD22 Recombinant Human B-cell receptor CD22 (CD22), partial, Biotinylated Mammalian cell C-terminal 6xHis-Avi-tagged CSB-MP004900HU-B
CD28 Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28), partial Mammalian cell C-terminal hFc-tagged CSB-MP004913HU1
CD40 Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) Mammalian cell C-terminal Fc-tagged CSB-AP005181HU
CD40 Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) Mammalian cell C-terminal hFc-tagged CSB-MP004936HU1
CD40 Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial E.coli C-terminal 6xHis-tagged CSB-EP851448PI
CD40 Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial Yeast C-terminal hFc-tagged CSB-YP851448PI
CD40 Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial Yeast C-terminal 6xHis-tagged CSB-YP851448PIc7
CD40 Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial Baculovirus C-terminal hFc-Avi-tagged CSB-BP004936HU1
CD40LG Recombinant Macaca mulatta CD40 ligand (CD40LG), partial E.coli N-terminal 6xHis-tagged CSB-EP004937MOW
CD40LG Recombinant Rabbit CD40 ligand (CD40LG), partial E.coli N-terminal 6xHis-tagged CSB-EP004937RB
CD40LG Recombinant Human CD40 ligand (CD40LG), partial E.coli N-terminal GST-tagged CSB-RP060054h
CD40LG Recombinant Human CD40 ligand (CD40LG), partial Yeast N-terminal 6xHis-tagged CSB-YP004937HU1
CD40LG Recombinant Rabbit CD40 ligand (CD40LG), partial Yeast N-terminal 6xHis-tagged CSB-YP004937RB
CD40LG Recombinant Human CD40 ligand (CD40LG), partial (Active) E.coli Tag-Free CSB-AP005191HU
CD40LG Recombinant Human CD40 ligand (CD40LG), partial (Active) Mammalian cell N-terminal hFc-Flag-tagged CSB-MP004937HU3
CD40LG Recombinant Human CD40 ligand (CD40LG), partial, Biotinylated Mammalian cell N-terminal hFc-Avi-tagged CSB-MP004937HU3-B
CD40LG Recombinant Human CD40 ligand (CD40LG), partial E.coli N-terminal 6xHis-tagged CSB-EP004937HU1a0
FCGRT Recombinant Human IgG receptor FcRn large subunit p51 (FCGRT), partial E.coli N-terminal GST-tagged CSB-EP008545HU

● 抗體

CD22 Recombinant Monoclonal Antibody
CSB-RA962691A0HU
CSB-RA962691A0HU IHC

Tested Applications:
ELISA, IHC

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU
CSB-RA004936MA1HU FC

Tested Applications:
ELISA, IF, FC

MS4A1 Recombinant Monoclonal Antibody
CSB-RA015007MA4HU
CSB-RA015007MA4HU IF

Tested Applications:
ELISA, IHC, IF

PDCD1 Recombinant Monoclonal Antibody
CSB-RA240597A0HU
CSB-RA240597A0HU WB

Tested Applications:
ELISA, WB, IHC

- 重組抗體

Target Product Name Species Reactivity Tested Applications Code
CD22 CD22 Recombinant Monoclonal Antibody Human ELISA, IHC CSB-RA962691A0HU
CD40 CD40 Recombinant Monoclonal Antibody Human ELISA, IF, FC CSB-RA004936MA1HU
IFNAR1 IFNAR1 Recombinant Monoclonal Antibody Human ELISA CSB-RA011046A0HU
IL23A IL23A Recombinant Monoclonal Antibody Human ELISA, WB CSB-RA251959A0HU
MS4A1 CD20 Recombinant Monoclonal Antibody Human ELISA CSB-RA015007A0HU
MS4A1 MS4A1 Recombinant Monoclonal Antibody Human ELISA CSB-RA015007A1HU
MS4A1 MS4A1 Recombinant Monoclonal Antibody Human, Dog, Macaca fascicularis ELISA CSB-RA015007MA3HU
MS4A1 MS4A1 Recombinant Monoclonal Antibody Human ELISA, IHC, IF CSB-RA015007MA4HU
PDCD1 PDCD1 Recombinant Monoclonal Antibody Human ELISA, WB, IHC CSB-RA240597A0HU

- 單克隆抗體

Target Product Name Species Reactivity Tested Applications Code
MS4A1 MS4A1 Monoclonal Antibody Human,Mouse,Rat ELISA, IHC CSB-MA000204
MS4A1 MS4A1 Monoclonal Antibody Human ELISA, IHC CSB-MA996413

- 多克隆抗體

Target Product Name Species Reactivity Tested Applications Code
CD22 CD22 Antibody Human ELISA, IHC CSB-PA004900ESR1HU
CD22 CD22 Antibody Human ELISA, WB CSB-PA070294
CD22 Phospho-CD22 (Y807) Antibody Human ELISA, WB, IHC CSB-PA070293
CD22 CD22 Antibody Human ELISA, IHC CSB-PA616669
CD22 CD22 Antibody Human ELISA, IHC CSB-PA576542
CD22 CD22 Antibody Human ELISA, WB CSB-PA828492
CD22 CD22 (Ab-807) Antibody Human ELISA, WB CSB-PA953915
CD22 Phospho-CD22 (Tyr807) Antibody Human ELISA, WB CSB-PA912726
CD28 CD28 Antibody Human ELISA, WB CSB-PA005199
CD28 Phospho-CD28 (Y218) Antibody Human, Mouse ELISA, WB CSB-PA070302
CD40 CD40 Antibody Human, Mouse ELISA, WB, IF CSB-PA004936LA01HU
CD40 CD40 Antibody Human, Mouse, Monkey ELISA, WB, IHC CSB-PA001455
CD40 Phospho-CD40 (T254) Antibody Human, Mouse ELISA, WB CSB-PA080031
CD40 CD40 Antibody Human ELISA, WB CSB-PA004936GA01HU
CD40 CD40 Antibody Human, Mouse ELISA, IHC CSB-PA215588
CD40 Phospho-CD40 (Thr254) Antibody Human, Mouse ELISA, WB CSB-PA176134
CD40LG CD40LG Antibody Human ELISA CSB-PA06005A0Rb
CD40LG CD40LG Antibody Human, Mouse, Rat ELISA, WB, IHC CSB-PA004937GA01HU
CD40LG CD40LG Antibody Human, Mouse ELISA, WB CSB-PA067336
FCGRT FCGRT Antibody Human, Mouse ELISA, WB, IHC, IF CSB-PA008545EA01HU

● ELISA試劑盒

Target Product Name Sample Types Detection Range Code
CD40LG Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit serum, plasma, tissue homogenates 0.312 ng/mL-20 ng/mL CSB-E04716h
CD40 Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit Request Information CSB-EL004936MO
CD40LG Mouse Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit serum, plasma, tissue homogenates, cell culture supernates. 0.274 ng/ml-200 ng/ml. CSB-E04717m
CD40LG Rat Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit serum, plasma, tissue homogenates 1.87 ng/mL-120 ng/mL CSB-E07395r
CD28 Human soluble cluster of differentiation 28,sCD28 ELISA Kit serum, plasma, tissue homogenates 0.625 ng/mL-40 ng/mL CSB-E09296h
TNFSF13B Human B cell activation factor,BAFF ELISA Kit serum, plasma, tissue homogenates 0.312 ng/mL-20 ng/mL CSB-E11912h
PDCD1 Mouse Programmed Death 1(PD-1)ELISA Kit serum, plasma, tissue homogenates, cell lysates 0.312 ng/mL-20 ng/mL CSB-E13586m
PDCD1 Human Programmed Death 1(PD-1)ELISA KIT serum, plasma, tissue homogenates, cell lysates 15.6 pg/mL-1000 pg/mL CSB-E13643h
MS4A1 Human B-lymphocyte antigen (CD20) ELISA Kit serum, plasma, tissue homogenates 3.12 ng/mL-200 ng/mL CSB-E14007h
IL12A Bovine Interleukin 12,IL-12 ELISA Kit serum, plasma, tissue homogenates 6.25 pg/mL-400 pg/mL CSB-E14010B
IL7R Human Soluble Interleukin-7 Receptor,sIL-7R ELISA Kit serum, plasma, tissue homogenates 0.78 ng/mL-50 ng/mL CSB-E14020h
IL23A Human Interleukin-23 subunit alpha(IL-23A) Elisa kit serum, plasma, cell culture supernates, tissue homogenates, cell lysates 62.5 pg/mL-4000 pg/mL CSB-E17339h
FCGRT Human IgG receptor FcRn large subunit p51(FCGRT) ELISA kit serum, plasma, tissue homogenates 15.6 pg/mL-1000 pg/mL CSB-EL008545HU
ICOSLG Human ICOS ligand(ICOSLG) ELISA kit serum, plasma, tissue homogenates 93.75 pg/mL-6000 pg/mL CSB-EL010958HU
ICOSLG Mouse ICOS ligand(ICOSLG) ELISA kit serum, plasma, tissue homogenates 62.5 pg/mL-4000 pg/mL CSB-EL010958MO
IFNA2 Human interferon alpha-2(IFNA2) ELISA kit serum, plasma, cell culture supernates, tissue homogenates 31.25 pg/mL-2000 pg/mL CSB-EL011038HU
IFNA2 Mouse interferon alpha-2(IFNA2) ELISA kit serum, plasma, tissue homogenates, cell lysates 9.38 pg/mL-600 pg/mL CSB-EL011038MO
IL23A Pig Interleukin-23 subunit alpha(IL23A) ELISA kit serum, plasma, tissue homogenates 31.25 pg/mL-2000 pg/mL CSB-EL011638PI
IL7R Mouse Interleukin-7 receptor subunit alpha(IL7R) ELISA kit serum, plasma, tissue homogenates 78 pg/ml - 5000 pg/ml CSB-EL011670MO
TNFRSF13C Mouse Tumor necrosis factor receptor superfamily member 13C(TNFRSF13C) ELISA kit serum, plasma, tissue homogenates 39 pg/ml - 2500 pg/ml CSB-EL023972MO
自身免疫疾病