
干燥綜合征(Sj?gren's syndrome, SS)是一種慢性自身免疫性結(jié)締組織疾病,主要由遺傳、內(nèi)分泌、病毒感染等多種因素引發(fā),導(dǎo)致唾液腺、淚腺等外分泌腺功能受損,臨床表現(xiàn)為口干、眼干、皮膚干燥、關(guān)節(jié)疼痛、消化系統(tǒng)及呼吸系統(tǒng)等多系統(tǒng)受累癥狀。干燥綜合征可以分為原發(fā)性和繼發(fā)性兩種類型。原發(fā)性干燥綜合征(pSS)是指不伴有其他自身免疫性疾病的情況,而繼發(fā)性干燥綜合征則是與其他自身免疫性疾病如類風(fēng)濕關(guān)節(jié)炎或系統(tǒng)性紅斑狼瘡等并發(fā)的情況。
干燥綜合征的藥物研發(fā)主要集中在以下幾個方向:
- B細胞靶向療法:由于干燥綜合征是一種表現(xiàn)為B細胞高度活躍的疾病,B細胞亞群的異常在疾病的發(fā)生發(fā)展中可能扮演關(guān)鍵的角色,因此靶向B細胞的治療策略備受關(guān)注。目前研究的主要藥物包括靶向B細胞表面CD20的利妥昔單抗、靶向BAFF-R的單抗藥物Ianalumab,以及我國自主研發(fā)的1.1類新藥艾拉莫德(IGU),這些藥物均針對B細胞的存活或功能進行抑制。
- FcRn單抗療法:Nipocalimab是一種抗新生兒Fc受體(FcRn)的單克隆抗體,通過選擇性阻斷IgG與FcRn的相互作用以降低包括自身抗體在內(nèi)的循環(huán)IgG水平,從而改善干燥綜合征患者的病情。這一療法的有效性已在臨床II期研究中得到驗證。
- CD40L拮抗劑:Dazodalibep是一種非抗體融合蛋白,可作為CD40L拮抗劑,阻斷T細胞、B細胞和抗原呈遞細胞之間的協(xié)同刺激信號,從而降低與B細胞、T細胞和樹突狀細胞生物標志物相關(guān)的多種蛋白質(zhì)在干燥綜合征患者中的水平。
- TYK2抑制劑:氘可來昔替尼(BMS-986165)是一種高效選擇性的TYK2變構(gòu)抑制劑,可靶向作用于干燥綜合征相關(guān)細胞因子(包括I型IFN、白介素-12和白介素-23),通過阻斷這些通路的信號傳導(dǎo)來發(fā)揮作用,該藥物已在2023年批準上市。
其他如CD19、CD22、IL2R、IL17R等也是干燥綜合征藥物研發(fā)的重要靶點。針對這些靶點的藥物也在臨床研發(fā)中,并顯示出一定的療效。
華美生物長期致力于為科研工作者提供高質(zhì)量的蛋白、抗體、ELISA試劑盒等工具類科研試劑產(chǎn)品,特整理了一系列與干燥綜合征研究相關(guān)的熱門靶點及相關(guān)試劑產(chǎn)品列舉如下,供您選擇:
干燥綜合征在研藥物靶點
干燥綜合征藥物靶點相關(guān)產(chǎn)品推薦
● 靶點蛋白
CSB-MP004900HU

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.
CSB-MP004936HU1

Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.
CSB-MP004937HU3

Measured by its binding ability in a functional ELISA. Immobilized CD40L at 2 μg/ml can bind Anti- CD40L Rabbit Monoclonal Antibody(CSB-RA156386A0HU), the EC50 is 2.353-3.232 ng/ml.
CSB-MP010958HU1

Measured by its binding ability in a functional ELISA. Immobilized ICOSLG at 2 μg/ml can bind human ICOS (CSB-MP707478HU), the EC50 of human ICOSLG protein is 29.04-43.59 ng/ml
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP853495HU1

Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B (CSB-MP897523HU1) at 2 μg/ml can bind TNFRSF13C, the EC50 is 9.943-15.72 ng/ml
CSB-MP897523HU1

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.
Target | Product Name | Source | Tag Info | Product Code |
---|---|---|---|---|
CD22 | Recombinant Human B-cell receptor CD22 (CD22), partial | E.coli | N-terminal 6xHis-SUMO-tagged | CSB-EP004900HU1 |
CD22 | Recombinant Human B-cell receptor CD22 (CD22), partial (Active) | Mammalian cell | C-terminal 6xHis-tagged | CSB-MP004900HU |
CD22 | Recombinant Human B-cell receptor CD22 (CD22), partial, Biotinylated | Mammalian cell | C-terminal 6xHis-Avi-tagged | CSB-MP004900HU-B |
CD28 | Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28), partial | Mammalian cell | C-terminal hFc-tagged | CSB-MP004913HU1 |
CD40 | Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) | Mammalian cell | C-terminal Fc-tagged | CSB-AP005181HU |
CD40 | Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) | Mammalian cell | C-terminal hFc-tagged | CSB-MP004936HU1 |
CD40 | Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial | E.coli | C-terminal 6xHis-tagged | CSB-EP851448PI |
CD40 | Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial | Yeast | C-terminal hFc-tagged | CSB-YP851448PI |
CD40 | Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial | Yeast | C-terminal 6xHis-tagged | CSB-YP851448PIc7 |
CD40 | Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial | Baculovirus | C-terminal hFc-Avi-tagged | CSB-BP004936HU1 |
CD40LG | Recombinant Macaca mulatta CD40 ligand (CD40LG), partial | E.coli | N-terminal 6xHis-tagged | CSB-EP004937MOW |
CD40LG | Recombinant Rabbit CD40 ligand (CD40LG), partial | E.coli | N-terminal 6xHis-tagged | CSB-EP004937RB |
CD40LG | Recombinant Human CD40 ligand (CD40LG), partial | E.coli | N-terminal GST-tagged | CSB-RP060054h |
CD40LG | Recombinant Human CD40 ligand (CD40LG), partial | Yeast | N-terminal 6xHis-tagged | CSB-YP004937HU1 |
CD40LG | Recombinant Rabbit CD40 ligand (CD40LG), partial | Yeast | N-terminal 6xHis-tagged | CSB-YP004937RB |
CD40LG | Recombinant Human CD40 ligand (CD40LG), partial (Active) | E.coli | Tag-Free | CSB-AP005191HU |
CD40LG | Recombinant Human CD40 ligand (CD40LG), partial (Active) | Mammalian cell | N-terminal hFc-Flag-tagged | CSB-MP004937HU3 |
CD40LG | Recombinant Human CD40 ligand (CD40LG), partial, Biotinylated | Mammalian cell | N-terminal hFc-Avi-tagged | CSB-MP004937HU3-B |
CD40LG | Recombinant Human CD40 ligand (CD40LG), partial | E.coli | N-terminal 6xHis-tagged | CSB-EP004937HU1a0 |
FCGRT | Recombinant Human IgG receptor FcRn large subunit p51 (FCGRT), partial | E.coli | N-terminal GST-tagged | CSB-EP008545HU |
● 抗體
CSB-RA962691A0HU

Tested Applications:
ELISA, IHC
CSB-RA004936MA1HU

Tested Applications:
ELISA, IF, FC
CSB-RA015007MA4HU

Tested Applications:
ELISA, IHC, IF
CSB-RA240597A0HU

Tested Applications:
ELISA, WB, IHC
- 重組抗體
Target | Product Name | Species Reactivity | Tested Applications | Code |
---|---|---|---|---|
CD22 | CD22 Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA962691A0HU |
CD40 | CD40 Recombinant Monoclonal Antibody | Human | ELISA, IF, FC | CSB-RA004936MA1HU |
IFNAR1 | IFNAR1 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA011046A0HU |
IL23A | IL23A Recombinant Monoclonal Antibody | Human | ELISA, WB | CSB-RA251959A0HU |
MS4A1 | CD20 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA015007A0HU |
MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA015007A1HU |
MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human, Dog, Macaca fascicularis | ELISA | CSB-RA015007MA3HU |
MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF | CSB-RA015007MA4HU |
PDCD1 | PDCD1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC | CSB-RA240597A0HU |
- 單克隆抗體
Target | Product Name | Species Reactivity | Tested Applications | Code |
---|---|---|---|---|
MS4A1 | MS4A1 Monoclonal Antibody | Human,Mouse,Rat | ELISA, IHC | CSB-MA000204 |
MS4A1 | MS4A1 Monoclonal Antibody | Human | ELISA, IHC | CSB-MA996413 |
- 多克隆抗體
Target | Product Name | Species Reactivity | Tested Applications | Code |
---|---|---|---|---|
CD22 | CD22 Antibody | Human | ELISA, IHC | CSB-PA004900ESR1HU |
CD22 | CD22 Antibody | Human | ELISA, WB | CSB-PA070294 |
CD22 | Phospho-CD22 (Y807) Antibody | Human | ELISA, WB, IHC | CSB-PA070293 |
CD22 | CD22 Antibody | Human | ELISA, IHC | CSB-PA616669 |
CD22 | CD22 Antibody | Human | ELISA, IHC | CSB-PA576542 |
CD22 | CD22 Antibody | Human | ELISA, WB | CSB-PA828492 |
CD22 | CD22 (Ab-807) Antibody | Human | ELISA, WB | CSB-PA953915 |
CD22 | Phospho-CD22 (Tyr807) Antibody | Human | ELISA, WB | CSB-PA912726 |
CD28 | CD28 Antibody | Human | ELISA, WB | CSB-PA005199 |
CD28 | Phospho-CD28 (Y218) Antibody | Human, Mouse | ELISA, WB | CSB-PA070302 |
CD40 | CD40 Antibody | Human, Mouse | ELISA, WB, IF | CSB-PA004936LA01HU |
CD40 | CD40 Antibody | Human, Mouse, Monkey | ELISA, WB, IHC | CSB-PA001455 |
CD40 | Phospho-CD40 (T254) Antibody | Human, Mouse | ELISA, WB | CSB-PA080031 |
CD40 | CD40 Antibody | Human | ELISA, WB | CSB-PA004936GA01HU |
CD40 | CD40 Antibody | Human, Mouse | ELISA, IHC | CSB-PA215588 |
CD40 | Phospho-CD40 (Thr254) Antibody | Human, Mouse | ELISA, WB | CSB-PA176134 |
CD40LG | CD40LG Antibody | Human | ELISA | CSB-PA06005A0Rb |
CD40LG | CD40LG Antibody | Human, Mouse, Rat | ELISA, WB, IHC | CSB-PA004937GA01HU |
CD40LG | CD40LG Antibody | Human, Mouse | ELISA, WB | CSB-PA067336 |
FCGRT | FCGRT Antibody | Human, Mouse | ELISA, WB, IHC, IF | CSB-PA008545EA01HU |
● ELISA試劑盒
Target | Product Name | Sample Types | Detection Range | Code |
---|---|---|---|---|
CD40LG | Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | serum, plasma, tissue homogenates | 0.312 ng/mL-20 ng/mL | CSB-E04716h |
CD40 | Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit | Request Information | CSB-EL004936MO | |
CD40LG | Mouse Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | serum, plasma, tissue homogenates, cell culture supernates. | 0.274 ng/ml-200 ng/ml. | CSB-E04717m |
CD40LG | Rat Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | serum, plasma, tissue homogenates | 1.87 ng/mL-120 ng/mL | CSB-E07395r |
CD28 | Human soluble cluster of differentiation 28,sCD28 ELISA Kit | serum, plasma, tissue homogenates | 0.625 ng/mL-40 ng/mL | CSB-E09296h |
TNFSF13B | Human B cell activation factor,BAFF ELISA Kit | serum, plasma, tissue homogenates | 0.312 ng/mL-20 ng/mL | CSB-E11912h |
PDCD1 | Mouse Programmed Death 1(PD-1)ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.312 ng/mL-20 ng/mL | CSB-E13586m |
PDCD1 | Human Programmed Death 1(PD-1)ELISA KIT | serum, plasma, tissue homogenates, cell lysates | 15.6 pg/mL-1000 pg/mL | CSB-E13643h |
MS4A1 | Human B-lymphocyte antigen (CD20) ELISA Kit | serum, plasma, tissue homogenates | 3.12 ng/mL-200 ng/mL | CSB-E14007h |
IL12A | Bovine Interleukin 12,IL-12 ELISA Kit | serum, plasma, tissue homogenates | 6.25 pg/mL-400 pg/mL | CSB-E14010B |
IL7R | Human Soluble Interleukin-7 Receptor,sIL-7R ELISA Kit | serum, plasma, tissue homogenates | 0.78 ng/mL-50 ng/mL | CSB-E14020h |
IL23A | Human Interleukin-23 subunit alpha(IL-23A) Elisa kit | serum, plasma, cell culture supernates, tissue homogenates, cell lysates | 62.5 pg/mL-4000 pg/mL | CSB-E17339h |
FCGRT | Human IgG receptor FcRn large subunit p51(FCGRT) ELISA kit | serum, plasma, tissue homogenates | 15.6 pg/mL-1000 pg/mL | CSB-EL008545HU |
ICOSLG | Human ICOS ligand(ICOSLG) ELISA kit | serum, plasma, tissue homogenates | 93.75 pg/mL-6000 pg/mL | CSB-EL010958HU |
ICOSLG | Mouse ICOS ligand(ICOSLG) ELISA kit | serum, plasma, tissue homogenates | 62.5 pg/mL-4000 pg/mL | CSB-EL010958MO |
IFNA2 | Human interferon alpha-2(IFNA2) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 31.25 pg/mL-2000 pg/mL | CSB-EL011038HU |
IFNA2 | Mouse interferon alpha-2(IFNA2) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 9.38 pg/mL-600 pg/mL | CSB-EL011038MO |
IL23A | Pig Interleukin-23 subunit alpha(IL23A) ELISA kit | serum, plasma, tissue homogenates | 31.25 pg/mL-2000 pg/mL | CSB-EL011638PI |
IL7R | Mouse Interleukin-7 receptor subunit alpha(IL7R) ELISA kit | serum, plasma, tissue homogenates | 78 pg/ml - 5000 pg/ml | CSB-EL011670MO |
TNFRSF13C | Mouse Tumor necrosis factor receptor superfamily member 13C(TNFRSF13C) ELISA kit | serum, plasma, tissue homogenates | 39 pg/ml - 2500 pg/ml | CSB-EL023972MO |