冠狀病毒
冠狀病毒是一類(lèi)通常影響鳥(niǎo)類(lèi)和哺乳動(dòng)物，包括人類(lèi)呼吸道的病毒。"冠狀病毒"一詞來(lái)源于其表面的冠狀突起。拉丁文中，“corona”意為“光環(huán)”或“王冠”。
科學(xué)家最早于1937年分離出一種冠狀病毒，他們發(fā)現(xiàn)一種冠狀病毒是鳥(niǎo)類(lèi)傳染性支氣管炎病毒，有能力摧毀家禽存欄。冠狀病毒亞科的成員在哺乳動(dòng)物中廣泛分布，通常只引起輕微的呼吸道或腸道感染。超過(guò)60種冠狀病毒（CoVs）已從蝙蝠（BtCoV）中分離出來(lái)，其中大多數(shù)屬于β冠狀病毒屬。
人類(lèi)冠狀病毒（HCoVs）
人類(lèi)冠狀病毒（HCoVs）屬于Nidovirales目，Coronaviridae科，Coronavirinae亞科，Alphacoronavirus屬或Betacoronavirus屬。上世紀(jì)60年代在感冒患者的鼻子中首次發(fā)現(xiàn)了HCoVs，它們代表了與多種呼吸道疾病相關(guān)的冠狀病毒（CoVs）的一個(gè)主要群體，包括普通感冒、肺炎和支氣管炎等 [1]。它們通常引起短暫的呼吸道或胃腸道疾病。
迄今為止，已經(jīng)確定了七種已知的HCoVs，即HCoV-229E、HCoV-NL63、HCoV-OC43、HCoV-HKU1、嚴(yán)重急性呼吸綜合癥冠狀病毒（SARS-CoV）、中東呼吸綜合癥冠狀病毒（MERS-CoV）和2019新型冠狀病毒（SARS-CoV-2）。
其中，四種HCoVs（HCoV-229E、HCoV-NL63、HCoV-OC43和HCoV-HKU1）在人群中廣泛傳播，占人類(lèi)普通感冒感染的約三分之一 [2]。
Human Novel Coronavirus (SARS-CoV-2)
| Product Name | Target | Source | Tag Info | Product Code |
|---|---|---|---|---|
| Recombinant Human Novel Coronavirus Non-structural protein 8 (ns8) | NSP8 | E.coli | N-terminal 6xHis-tagged | CSB-EP3366GND |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Non-structural protein 9 (nsp9) | Nsp9 | Mammalian cell | C-terminal hFc-Flag-tagged | CSB-MP3388GND |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Non-structural protein 9 (nsp9) | Nsp9 | E.coli | C-terminal 10xHis-tagged | CSB-EP3388GND |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Envelope small membrane protein & Membrane protein (E & M), partial | E & M | E.coli | N-terminal 6xHis-SUMO-tagged | CSB-EP3402GND |
| Recombinant Severe acute respiratory syndrome coronavirus 2 RNA-dependent RNA polymerase (NSP12) | NSP12 | E.coli | N-terminal 6xHis-tagged | CSB-EP3371GND |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (Active) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP3325GMY |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (T205I) (Active) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP3325GMY(M2) |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (P80R) (Active) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP3325GMY(M3) |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (P13L) (Active) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP3325GMY(M4) |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (D103Y) (Active) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP3325GMY(M5) |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (L230F) (Active) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP3325GMY(M9) |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (I292T) (Active) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP3325GMY(M10) |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (Q384H) (Active) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP3325GMY(M11) |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (R203K,G204R) (Active) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP3325GMY(M12) |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (D3L,R203K,G204R,S235F) (Active) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP3325GMY(M1) |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (S202N) (Active) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP3325GMY(M8) |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (R203M,D377Y) (Active) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP3325GMY(M13) |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (D63G,R203M,D377Y) (Active) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP3325GMY(M14) |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N), partial | N | E.coli | C-terminal 10xHis-tagged | CSB-EP3325GMY1 |
| Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N), Biotinylated | N | E.coli | N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged | CSB-EP3325GMY-B |
Human SARS coronavirus (SARS-CoV)
| Product Name | Target | Source | Tag Info | Product Code |
|---|---|---|---|---|
| Recombinant Human SARS coronavirus Protein non-structural 7b (7b), partial | 7b | E.coli | N-terminal GST-tagged | CSB-EP756006HQE |
| Recombinant Human SARS coronavirus Nucleoprotein (N) | N | Baculovirus | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-BP349523HQE |
| Recombinant Human SARS coronavirus Nucleoprotein (N) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP349523HQE |
| Recombinant Human SARS coronavirus Spike glycoprotein (S), partial (Active) | S | Mammalian cell | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-MP348663HQE |
| Recombinant Human SARS coronavirus Spike glycoprotein (S), partial | S | Yeast | N-terminal 6xHis-tagged | CSB-YP348663HQE |
| Recombinant Human SARS coronavirus Spike glycoprotein (S), partial | S | Yeast | N-terminal 6xHis-sumostar-tagged | CSB-YP348663HQEa4 |
| Recombinant Severe acute respiratory syndrome coronavirus 3C-like proteinase, partial | N/A | in vitro E.coli expression system | N-terminal 10xHis-tagged | CSB-CF3621GOU |
| Recombinant Severe acute respiratory syndrome coronavirus Spike glycoprotein (S), partial | S | Mammalian cell | C-terminal 6xHis-tagged | CSB-MP348663HQEc7 |
| Recombinant SARS coronavirus MA15 3C-like proteinase, partial | N/A | in vitro E.coli expression system | N-terminal 10xHis-tagged | CSB-CF3622GOV |
Human coronavirus 229E (HCoV-229E)
| Product Name | Target | Source | Tag Info | Product Code |
|---|---|---|---|---|
| Recombinant Human coronavirus 229E Membrane protein (M), partial | M | E.coli | N-terminal 10xHis-tagged | CSB-EP323624HIT1 |
| Recombinant Human coronavirus 229E Nucleoprotein (N) | N | Mammalian cell | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-MP322753HIT |
| Recombinant Human coronavirus 229E Nucleoprotein (N) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP322753HIT |
| Recombinant Human coronavirus 229E Nucleoprotein (N) | N | Baculovirus | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-BP322753HIT |
| Recombinant Human coronavirus 229E Nucleoprotein (N) | N | Mammalian cell | C-terminal 6xHis-tagged | CSB-MP322753HITc7 |
| Recombinant Human coronavirus 229E Nucleoprotein (N) | N | E.coli | C-terminal 6xHis-tagged | CSB-EP322753HITc7 |
| Recombinant Human coronavirus 229E Spike glycoprotein (S), partial | S | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-EP321366HIT |
| Recombinant Human coronavirus 229E Spike glycoprotein (S), partial | S | Mammalian cell | C-terminal 6xHis-tagged | CSB-MP321366HIT1 |
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1)
| Product Name | Target | Source | Tag Info | Product Code |
|---|---|---|---|---|
| Recombinant Human coronavirus HKU1 Non-structural protein 4 (4) | 4 | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-EP689643HIU |
| Recombinant Human coronavirus HKU1 Non-structural protein 4 (4) | 4 | E.coli | C-terminal 6xHis-tagged | CSB-EP689643HIUc7 |
| Recombinant Human coronavirus HKU1 Non-structural protein 4 (4) | 4 | Baculovirus | C-terminal 6xHis-tagged | CSB-BP689643HIUc7 |
| Recombinant Human coronavirus HKU1 Non-structural protein 4 (4) | 4 | Yeast | C-terminal 6xHis-tagged | CSB-YP689643HIU |
| Recombinant Human coronavirus HKU1 Nucleoprotein (N) | N | Baculovirus | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-BP683657HIU |
| Recombinant Human coronavirus HKU1 Nucleoprotein (N) | N | E.coli | C-terminal 6xHis-tagged | CSB-EP683657HIUc7 |
| Recombinant Human coronavirus HKU1 Protein I (N) | N | E.coli | C-terminal 6xHis-tagged | CSB-EP683656HIUc7 |
| Recombinant Human coronavirus HKU1 Protein I (N) | N | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-EP683656HIU |
| Recombinant Human coronavirus HKU1 Spike glycoprotein (S), partial | S | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-EP708794HIU |
| Recombinant Human coronavirus HKU1 Spike glycoprotein (S), partial | S | E.coli | C-terminal 6xHis-tagged | CSB-EP708794HIUc7 |
| Recombinant Human coronavirus HKU1 Hemagglutinin-esterase (HE) | HE | in vitro E.coli expression system | N-terminal 10xHis-tagged | CSB-CF613540HIV |
| Recombinant Human coronavirus HKU1 Spike glycoprotein (S), partial | S | E.coli | C-terminal 6xHis-tagged | CSB-EP618924HIV |
| Recombinant Human coronavirus HKU1 Spike glycoprotein (S), partial | S | Yeast | C-terminal 6xHis-tagged | CSB-YP618924HIV |
| Recombinant Human coronavirus HKU1 Non-structural protein 4 (4) | 4 | E.coli | N-terminal 6xHis-tagged | CSB-EP608711HIW |
| Recombinant Human coronavirus HKU1 Non-structural protein 4 (4) | 4 | Yeast | C-terminal 6xHis-tagged | CSB-YP608711HIW |
| Recombinant Human coronavirus HKU1 Nucleoprotein (N) | N | Mammalian cell | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-MP607323HIW |
| Recombinant Human coronavirus HKU1 Nucleoprotein (N) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP607323HIW |
| Recombinant Human coronavirus HKU1 Protein I (N) | N | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-EP605916HIW |
| Recombinant Human coronavirus HKU1 Nucleoprotein (N) | N | E.coli | C-terminal 6xHis-tagged | CSB-EP607323HIWc7 |
| Recombinant Human coronavirus HKU1 Spike glycoprotein (S), partial | S | Mammalian cell | C-terminal mFc-tagged | CSB-MP611894HIWh8 |
| Recombinant Human coronavirus HKU1 Spike glycoprotein (S), partial | S | E.coli | C-terminal 6xHis-tagged | CSB-EP611894HIW |
| Recombinant Human coronavirus HKU1 Spike glycoprotein (S), partial | S | Yeast | C-terminal 6xHis-tagged | CSB-YP611894HIW |
Human coronavirus NL63 (HCoV-NL63)
| Product Name | Target | Source | Tag Info | Product Code |
|---|---|---|---|---|
| Recombinant Human coronavirus NL63 Envelope small membrane protein (E) | E | in vitro E.coli expression system | N-terminal 10xHis-tagged | CSB-CF764822HIX |
| Recombinant Human coronavirus NL63 Membrane protein (M) | M | in vitro E.coli expression system | N-terminal 10xHis-tagged | CSB-CF757672HIX |
| Recombinant Human coronavirus NL63 Nucleoprotein (N) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP744150HIX |
| Recombinant Human coronavirus NL63 Nucleoprotein (N) | N | Baculovirus | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-BP744150HIX |
| Recombinant Human coronavirus NL63 Spike glycoprotein (S), partial | S | Yeast | N-terminal 6xHis-sumostar-tagged | CSB-YP747509HIX1 |
| Recombinant Human coronavirus NL63 Spike glycoprotein (S), partial | S | Yeast | N-terminal 6xHis-PDI-tagged | CSB-YP747509HIX |
Human coronavirus OC43 (HCoV-OC43)
| Product Name | Target | Source | Tag Info | Product Code |
|---|---|---|---|---|
| Recombinant Human coronavirus OC43 Non-structural protein 2a (2a) | 2a | Baculovirus | C-terminal 6xHis-tagged | CSB-BP767285HIY |
| Recombinant Human coronavirus OC43 Nucleoprotein (N) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP333798HIY |
| Recombinant Human coronavirus OC43 Nucleoprotein (N) | N | Mammalian cell | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-MP333798HIY |
| Recombinant Human coronavirus OC43 Nucleoprotein (N) | N | Mammalian cell | C-terminal hFc-tagged | CSB-MP333798HIYd9 |
| Recombinant Human coronavirus OC43 Nucleoprotein (N) | N | Baculovirus | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-BP333798HIY |
| Recombinant Human coronavirus OC43 Protein I (N) | N | E.coli | C-terminal 6xHis-tagged | CSB-EP700347HIY |
| Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | S | E.coli | N-terminal 6xHis-SUMO-tagged | CSB-EP336163HIY |
| Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | S | Baculovirus | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-BP336163HIY |
| Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | S | Yeast | N-terminal 6xHis-tagged | CSB-YP336163HIY |
| Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | S | Mammalian cell | C-terminal 6xHis-Myc-tagged | CSB-MP336163HIY1 |
| Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | S | E.coli | C-terminal 6xHis-tagged | CSB-EP336163HIY1 |
Human betacoronavirus
| Product Name | Target | Source | Tag Info | Product Code |
|---|---|---|---|---|
| Recombinant Human betacoronavirus 2c EMC/2012 Spike glycoprotein (S), partial | S | Yeast | N-terminal 6xHis-sumostar-tagged | CSB-YP3416GNJa4 |
| Recombinant Human betacoronavirus 2c EMC/2012 Spike glycoprotein (S), partial | S | Yeast | N-terminal 6xHis-tagged | CSB-YP3416GNJ |
| Recombinant Human betacoronavirus 2c EMC/2012 Spike glycoprotein (S), partial | S | Mammalian cell | C-terminal 6xHis-tagged | CSB-MP3416GNJ |
| Recombinant Human betacoronavirus 2c EMC/2012 Spike glycoprotein (S), partial | S | Mammalian cell | C-terminal mFc-tagged | CSB-MP3416GNJh8 |
Bat coronavirus
| Product Name | Target | Source | Tag Info | Product Code |
|---|---|---|---|---|
| Recombinant Bat coronavirus 133/2005 Nucleoprotein (N) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP605318BFA |
| Recombinant Bat coronavirus 133/2005 Nucleoprotein (N) | N | Baculovirus | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-BP605318BFA |
| Recombinant Bat coronavirus 133/2005 Spike glycoprotein (S), partial | S | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-EP610383BFA |
| Recombinant Bat coronavirus HKU3 Nucleoprotein2 (N) | N | Baculovirus | C-terminal 6xHis-tagged | CSB-BP664686BFDc7 |
| Recombinant Bat coronavirus HKU3 Nucleoprotein2 (N) | N | Baculovirus | C-terminal 6xHis-tagged | CSB-BP664686BFD |
| Recombinant Bat coronavirus HKU3 Spike glycoprotein (S), partial | S | Baculovirus | C-terminal 6xHis-tagged | CSB-BP663395BFD |
| Recombinant Bat coronavirus HKU3 Spike glycoprotein (S), partial | S | E.coli | N-terminal 6xHis-tagged | CSB-EP663395BFD |
| Recombinant Bat coronavirus HKU4 Nucleoprotein (N) | N | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-EP387608BOT |
| Recombinant Bat coronavirus HKU5 Nucleoprotein (N) | N | E.coli | C-terminal 6xHis-tagged | CSB-EP386462BOU |
| Recombinant Bat coronavirus HKU9 Nucleoprotein (N) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP385259BOVa0 |
| Recombinant Bat coronavirus HKU9 Nucleoprotein (N) | N | Baculovirus | C-terminal 6xHis-tagged | CSB-BP385259BOV |
| Recombinant Bat coronavirus HKU9 Spike glycoprotein (S), partial | S | E.coli | N-terminal 6xHis-tagged | CSB-EP385258BOV |
| Recombinant Bat coronavirus HKU9 Spike glycoprotein (S), partial | S | Baculovirus | C-terminal 6xHis-tagged | CSB-BP385258BOV |
Bovine coronavirus
| Product Name | Target | Source | Tag Info | Product Code |
|---|---|---|---|---|
| Recombinant Bovine coronavirus Non-structural protein 2a (2a) | 2a | Yeast | C-terminal 6xHis-tagged | CSB-YP838639BJE |
| Recombinant Bovine coronavirus Non-structural protein 2a (2a) | 2a | Baculovirus | C-terminal 6xHis-tagged | CSB-BP838639BJE |
| Recombinant Bovine coronavirus Protein I (N) | N | E.coli | C-terminal 6xHis-tagged | CSB-EP852737BJE |
| Recombinant Bovine coronavirus Spike glycoprotein (S), partial | S | Yeast | C-terminal 6xHis-tagged | CSB-YP820951BJE |
| Recombinant Bovine coronavirus Non-structural protein 2a (2a) | 2a | Mammalian cell | C-terminal 6xHis-tagged | CSB-MP855307BJF |
| Recombinant Bovine coronavirus Non-structural protein of 4.8 kDa (4b) | 4b | Yeast | C-terminal 6xHis-tagged | CSB-YP314697BJF |
| Recombinant Bovine coronavirus Non-structural protein of 12.7 kDa (5a) | 5a | E.coli | C-terminal 6xHis-tagged | CSB-EP848658BJF |
| Recombinant Bovine coronavirus Non-structural protein of 12.7 kDa (5a) | 5a | Baculovirus | C-terminal 6xHis-tagged | CSB-BP848658BJF |
| Recombinant Bovine coronavirus Nucleoprotein (N) | N | E.coli | C-terminal 6xHis-tagged | CSB-EP823718BJF |
| Recombinant Bovine coronavirus Protein I (N) | N | E.coli | C-terminal 6xHis-tagged | CSB-EP844974BJF |
| Recombinant Bovine coronavirus Spike glycoprotein (S), partial | S | Mammalian cell | C-terminal 6xHis-tagged | CSB-MP819726BJF |
| Recombinant Bovine coronavirus Nucleoprotein (N) | N | Mammalian cell | C-terminal 6xHis-tagged | CSB-MP321743BJG |
| Recombinant Bovine coronavirus Spike glycoprotein (S), partial | S | Yeast | C-terminal 6xHis-tagged | CSB-YP326525BJG |
| Recombinant Bovine coronavirus Spike glycoprotein (S), partial | S | Yeast | C-terminal 6xHis-tagged | CSB-YP338650BJH |
| Recombinant Bovine coronavirus Non-structural protein 2a (2a) | 2a | Baculovirus | C-terminal 6xHis-tagged | CSB-BP313890BJI |
| Recombinant Bovine coronavirus Non-structural protein 2a (2a) | 2a | E.coli | C-terminal 6xHis-tagged | CSB-EP313890BJI |
| Recombinant Bovine coronavirus Nucleoprotein (N) | N | E.coli | C-terminal 6xHis-tagged | CSB-EP889516BJI |
| Recombinant Bovine coronavirus Protein I (N) | N | E.coli | C-terminal 6xHis-tagged | CSB-EP868731BJI |
| Recombinant Bovine coronavirus Spike glycoprotein (S), partial | S | Mammalian cell | C-terminal 6xHis-tagged | CSB-MP874069BJI |
| Recombinant Bovine coronavirus Spike glycoprotein (S), partial | S | E.coli | C-terminal 6xHis-tagged | CSB-EP874069BJI |
Canine coronavirus
| Product Name | Target | Source | Tag Info | Product Code |
|---|---|---|---|---|
| Recombinant Canine coronavirus Nucleoprotein (N) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP745849CHAH |
| Recombinant Canine coronavirus Nucleoprotein (N) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP327521CCO |
| Recombinant Canine coronavirus Nucleoprotein (N) | N | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-EP327521CCOb1 |
| Recombinant Canine coronavirus Nucleoprotein (N) | N | E.coli | N-terminal 6xHis-tagged | CSB-EP312949CCP |
Feline coronavirus
| Product Name | Target | Source | Tag Info | Product Code |
|---|---|---|---|---|
| Recombinant Feline coronavirus Non-structural protein 7a (7a), partial | 7a | E.coli | N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged | CSB-EP321722FEJ |
| Recombinant Feline coronavirus Spike glycoprotein (S), partial | S | E.coli | C-terminal 6xHis-tagged | CSB-EP319859FEJ |
| Recombinant Feline coronavirus Spike glycoprotein (S), Partial | S | E.coli | N-terminal GST-tagged | CSB-EP319859FEJ1e0 |
| Recombinant Feline coronavirus Spike glycoprotein (S), Partial | S | E.coli | C-terminal 6xHis-tagged | CSB-EP319859FEJ1 |
| Recombinant Feline coronavirus Spike glycoprotein (S), Partial | S | E.coli | N-terminal 6xHis-SUMO-tagged | CSB-EP319859FEJ1a2 |
Other coronavirus
| Product Name | Target | Source | Tag Info | Product Code |
|---|---|---|---|---|
| Recombinant Middle East respiratory syndrome-related coronavirus Orf1ab, partial | N/A | E.coli | Tag-Free | CSB-EP2883GJE |
| Recombinant Porcine transmissible gastroenteritis coronavirus Nucleoprotein (N) | N | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-EP361212PQH |
冠狀病毒的傳播
冠狀病毒可以從一個(gè)人傳播到另一個(gè)人，科學(xué)家認(rèn)為這些病毒通過(guò)呼吸系統(tǒng)中的液體，如黏液，傳播。冠狀病毒可以通過(guò)以下方式傳播：
● 通過(guò)咳嗽和打噴嚏而進(jìn)入空氣中
● 密切的個(gè)人接觸，比如觸摸或握手
● 接觸帶有病毒的物體或表面，然后在洗手之前觸摸口、鼻或眼睛
由冠狀病毒引起的疾病
人類(lèi)冠狀病毒通常導(dǎo)致普通感冒而非嚴(yán)重疾病。然而，冠狀病毒也是一些更嚴(yán)重爆發(fā)的原因，如嚴(yán)重急性呼吸綜合癥（SARS）、中東呼吸綜合癥（MERS）和COVID-19。
SARS
SARS是由一種冠狀病毒引起的病毒性呼吸道疾病，稱(chēng)為嚴(yán)重急性呼吸綜合癥相關(guān)冠狀病毒（SARS-CoV）。通常，它導(dǎo)致一種危及生命的肺炎。SARS首次于2002年11月在亞洲報(bào)告。在接下來(lái)的幾個(gè)月里，這種疾病在北美、南美、歐洲和亞洲的兩打國(guó)家傳播，直到2003年SARS全球爆發(fā)得到控制 [3]。
根據(jù)世界衛(wèi)生組織（WHO）的數(shù)據(jù)，在SARS爆發(fā)期間，全球共有8,098人感染SARS，其中774人死亡。這相當(dāng)于9.6%的死亡率。
SARS的癥狀在一周的過(guò)程中逐漸發(fā)展，開(kāi)始于發(fā)熱。在疾病的早期階段，人們會(huì)出現(xiàn)類(lèi)似流感的癥狀，如干咳、寒戰(zhàn)、腹瀉、呼吸急促和疼痛。通常會(huì)發(fā)展為嚴(yán)重的肺部感染。在其最高級(jí)階段，SARS會(huì)導(dǎo)致肺部、心臟或肝臟的功能衰竭。
MERS
MERS是由一種冠狀病毒引起的，被稱(chēng)為中東呼吸綜合癥冠狀病毒（MERS-CoV）?？茖W(xué)家在2012年首次識(shí)別了這種嚴(yán)重的呼吸系統(tǒng)疾病，當(dāng)時(shí)它在沙特阿拉伯爆發(fā)。從那時(shí)起，它傳播到其他國(guó)家。MERS-CoV引起的臨床癥狀與SARS-CoV相似，但死亡率要高得多，約為35% [4]。
MERS的癥狀包括發(fā)熱、呼吸急促和咳嗽。該疾病通過(guò)與已經(jīng)感染的人密切接觸傳播。然而，所有MERS的病例都與最近從阿拉伯半島旅行歸來(lái)的個(gè)體有關(guān)。
COVID-19
2019年，疾病預(yù)防控制中心（CDC）開(kāi)始監(jiān)測(cè)一種新型冠狀病毒，SARS-CoV-2，導(dǎo)致現(xiàn)在被稱(chēng)為COVID-19的呼吸系統(tǒng)疾病的爆發(fā)。COVID-19的癥狀因人而異。它可能只引起很少或沒(méi)有癥狀。然而，它也可能導(dǎo)致嚴(yán)重的疾病，甚至致命。常見(jiàn)癥狀包括發(fā)熱、呼吸急促和咳嗽。有關(guān)COVID-19的更多信息，請(qǐng)閱讀2019新型冠狀病毒。
相關(guān)試劑產(chǎn)品
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