腦癌
腦癌是指發(fā)生在腦部的惡性腫瘤,包括原發(fā)性腦癌和繼發(fā)性腦癌。原發(fā)性腦癌起源于腦組織或鄰近組織,如腦膜,而繼發(fā)性腦癌則是由其他部位的癌癥轉(zhuǎn)移至腦部形成的。腦癌的癥狀多樣,包括頭痛、惡心、嘔吐、視力障礙、癲癇發(fā)作等,這些癥狀與腫瘤的大小、位置和生長(zhǎng)速度有關(guān)。
在腦癌的治療方面,傳統(tǒng)的治療手段包括手術(shù)切除、放療和化療。然而,由于血腦屏障的存在,許多藥物難以有效到達(dá)腦部腫瘤部位,限制了治療效果。近年來,針對(duì)腦癌的藥物研究主要集中在靶向治療和免疫治療領(lǐng)域。
- 靶向治療:靶向治療藥物通過特異性作用于腫瘤細(xì)胞的特定分子靶點(diǎn),從而抑制腫瘤的生長(zhǎng)和擴(kuò)散。例如,MET抑制劑卡馬替尼(Capmatinib)和特泊替尼(Tepotinib)已獲批上市,用于治療MET14外顯子跳躍突變的轉(zhuǎn)移性非小細(xì)胞肺癌,而MET抑制劑在腦癌領(lǐng)域的研究也在進(jìn)行中。
- 免疫治療:免疫治療通過激活或增強(qiáng)患者自身的免疫系統(tǒng)來攻擊腫瘤細(xì)胞。PD-1/L1抗體藥物如Nivolumab和Pembrolizumab已在一些腦癌治療中顯示出潛力,盡管目前針對(duì)GBM的III期臨床試驗(yàn)未獲成功,但免疫治療仍然是研究的熱點(diǎn)。
- 細(xì)胞免疫療法:包括CAR-T細(xì)胞療法和CIK細(xì)胞療法等,通過改造患者的免疫細(xì)胞使其能夠識(shí)別和攻擊腫瘤細(xì)胞。例如,靶向EGFRvIII的CAR-T產(chǎn)品正在開發(fā)中,用于治療GBM1。
- 溶瘤病毒療法:利用改造后的病毒特異性感染和殺死腫瘤細(xì)胞。例如,基于HSV-1改造的溶瘤病毒G207在治療兒童和青少年高級(jí)別膠質(zhì)瘤的臨床試驗(yàn)中顯示出生存期延長(zhǎng)的效果。
腦癌藥物靶點(diǎn)
腦癌藥物靶點(diǎn)相關(guān)產(chǎn)品推薦
● 靶點(diǎn)蛋白
CSB-MP007479HU

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.
CSB-MP733578HU

Measured by its binding ability in a functional ELISA. Immobilized CD276 at 2 μg/ml can bind Anti-CD276 rabbit monoclonal antibody, the EC50 of human CD276 protein is 1.961-2.243 ng/ml.
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP007763HU

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
CSB-MP023997HU1

Measured by its binding ability in a functional ELISA. Immobilized TNFSF9 at 2 μg/ml can bind TNFRSF9(CSB-MP023984HU1), the EC50 is 2.671-3.702 ng/mL
CSB-MP001707HU(A4)
-AC1.jpg)
Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody(CSB-RA001707MA01HU), the EC50 is 0.6666-0.8876 ng/mL
-AC1.jpg)
FACS assay shows that Human PVR can bind to HEK293F cell overexpressing human TIGIT.
● 重組抗體
CSB-RA878942MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.
CSB-RA004931MA1HU

Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100.
CSB-RA159341A0HU

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.
CSB-RA919940A0HU

Overlay Peak curve showing 3T3 cells stained with CSB-RA919940A0HU (red line) at 1:50.
產(chǎn)品名稱 | 貨號(hào) | 靶點(diǎn) | 反應(yīng)種屬 | 應(yīng)用范圍 |
---|---|---|---|---|
ANGPT2 Recombinant Monoclonal Antibody | CSB-RA191985A0HU | ANGPT2 | Human | ELISA, IHC |
ANGPT2 Recombinant Monoclonal Antibody | CSB-RA001707MA01HU | ANGPT2 | Human | ELISA |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD3E Recombinant Monoclonal Antibody | CSB-RA004931MA1HU | CD3E | Human | ELISA, FC |
CD47 Recombinant Monoclonal Antibody | CSB-RA802124A0HU | CD47 | Human | ELISA, WB, IHC, IF |
CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA3HU | CEACAM5 | Human | ELISA, IF, FC |
CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA1HU | CEACAM5 | Human | ELISA |
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | CSB-RA007479A1092phHU | EGFR | Human | ELISA, WB |
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | CSB-RA007479A1068phHU | EGFR | Human | ELISA, WB |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341A0HU | EGFR | Human | ELISA, WB, IHC, IF, FC |
EGFR Recombinant Monoclonal Antibody | CSB-RA794061A0HU | EGFR | Human | ELISA, WB, IHC |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341MA1HU | EGFR | Human | ELISA, IHC, FC |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA260392A0HU | ERBB2 | Human | ELISA, IHC, IF |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA007763MA1HU | ERBB2 | Human | ELISA |
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody | CSB-RA588766A0HU | ERBB2 | Human | ELISA, IHC, IF |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA007763MA2HU | ERBB2 | Human | ELISA, IHC |
ERBB3 Recombinant Monoclonal Antibody | CSB-RA937008A0HU | ERBB3 | Human | ELISA, IF |
FN1 Recombinant Monoclonal Antibody | CSB-RA921689A0HU | FN1 | Human | ELISA, IHC |
● ELISA試劑盒
產(chǎn)品名稱 | 貨號(hào) | 靶點(diǎn) | 檢測(cè)范圍 | 靈敏度 |
---|---|---|---|---|
Bovine Angiopoietin-1(ANGPT1) ELISA kit | CSB-EL001706BO | ANGPT1 | 12.5 ng/mL-800 ng/mL | 1.384 ng/mL |
Human Angiopoietin-1(ANGPT1) ELISA kit | CSB-EL001706HU | ANGPT1 | 1.25 ng/mL-80 ng/mL | 0.091 ng/mL |
Mouse Angiopoietin 1,ANG-1 ELISA Kit | CSB-E07302m | ANGPT1 | 1.25 ng/mL-80 ng/mL | 0.312 ng/mL |
Rat Angiopoietin 1,ANG-1 ELISA Kit | CSB-E07303r | ANGPT1 | 6.25 ng/mL-400 ng/mL | 1.56 ng/mL |
Pig Angiopoietin 1,ANG-1 ELISA Kit | CSB-E08457p | ANGPT1 | 6 ng/mL-200 ng/mL | 6 ng/mL |
Human Angiopoietin 2,ANG-2 ELISA Kit | CSB-E04500h | ANGPT2 | 39 pg/mL-2500 pg/mL | 9.75 pg/mL |
Rat Angiopoietin 2,ANG-2 ELISA Kit | CSB-E07304r | ANGPT2 | Request Information | Request Information |
Mouse Angiopoietin 2,ANG-2 ELISA Kit | CSB-E07305m | ANGPT2 | 0.156 pg/mL-10 pg/mL | 0.039 pg/mL |
Pig Angiopoietin 2,ANG-2 ELISA Kit | CSB-E08460p | ANGPT2 | 0.94 ng/mL-60 ng/mL | 0.235 ng/mL |
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit | CSB-EL004904HU | CD247 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit | CSB-E13644h | CD274 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit | CSB-EL004911MO | CD274 | 31.25 pg/mL-2000 pg/mL | 7.81 pg/mL |
Human Soluble CD276,sCD276/sB7-H3 ELISA Kit | CSB-E14285h | CD276 | 3.12 ng/mL-200 ng/mL | 0.78 ng/mL |
Human Leukocyte surface antigen CD47(CD47) ELISA kit | CSB-EL004940HU | CD47 | 3.12 pg/mL-200 pg/mL | 0.78 pg/mL |
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit | CSB-EL004940MO | CD47 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Human carcinoembryonic antigen,CEA ELISA Kit | CSB-E04767h | CEACAM5 | 5 ng/mL-120 ng/mL | 2 ng/mL |
Mouse carcinoembryonic antign,CEA ELISA Kit | CSB-E13925m | CEACAM5 | 62.5 pg/mL-4000 pg/mL | 15.6 pg/mL |
Human epidermal growth factor receptor,EGFR ELISA Kit | CSB-E12124h | EGFR | 0.312 ng/mL-20 ng/mL | 0.019 ng/mL |
Mouse Soluble Endoglin,ENG/sCD105 ELISA Kit | CSB-E09921m | ENG | 6.25 ng/mL-400 ng/mL | 1.56 ng/mL |
Human Soluble Endoglin,sENG/sCD105 ELISA Kit | CSB-E10030h | ENG | 0.156 ng/mL-10 ng/mL | 0.047 ng/mL |