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腦癌

腦癌是指發(fā)生在腦部的惡性腫瘤,包括原發(fā)性腦癌和繼發(fā)性腦癌。原發(fā)性腦癌起源于腦組織或鄰近組織,如腦膜,而繼發(fā)性腦癌則是由其他部位的癌癥轉(zhuǎn)移至腦部形成的。腦癌的癥狀多樣,包括頭痛、惡心、嘔吐、視力障礙、癲癇發(fā)作等,這些癥狀與腫瘤的大小、位置和生長(zhǎng)速度有關(guān)。

在腦癌的治療方面,傳統(tǒng)的治療手段包括手術(shù)切除、放療和化療。然而,由于血腦屏障的存在,許多藥物難以有效到達(dá)腦部腫瘤部位,限制了治療效果。近年來,針對(duì)腦癌的藥物研究主要集中在靶向治療和免疫治療領(lǐng)域。

  • 靶向治療:靶向治療藥物通過特異性作用于腫瘤細(xì)胞的特定分子靶點(diǎn),從而抑制腫瘤的生長(zhǎng)和擴(kuò)散。例如,MET抑制劑卡馬替尼(Capmatinib)和特泊替尼(Tepotinib)已獲批上市,用于治療MET14外顯子跳躍突變的轉(zhuǎn)移性非小細(xì)胞肺癌,而MET抑制劑在腦癌領(lǐng)域的研究也在進(jìn)行中。
  • 免疫治療:免疫治療通過激活或增強(qiáng)患者自身的免疫系統(tǒng)來攻擊腫瘤細(xì)胞。PD-1/L1抗體藥物如Nivolumab和Pembrolizumab已在一些腦癌治療中顯示出潛力,盡管目前針對(duì)GBM的III期臨床試驗(yàn)未獲成功,但免疫治療仍然是研究的熱點(diǎn)。
  • 細(xì)胞免疫療法:包括CAR-T細(xì)胞療法和CIK細(xì)胞療法等,通過改造患者的免疫細(xì)胞使其能夠識(shí)別和攻擊腫瘤細(xì)胞。例如,靶向EGFRvIII的CAR-T產(chǎn)品正在開發(fā)中,用于治療GBM1。
  • 溶瘤病毒療法:利用改造后的病毒特異性感染和殺死腫瘤細(xì)胞。例如,基于HSV-1改造的溶瘤病毒G207在治療兒童和青少年高級(jí)別膠質(zhì)瘤的臨床試驗(yàn)中顯示出生存期延長(zhǎng)的效果。

腦癌藥物靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

CSB-MP007479HU Activity Verified

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

CSB-MP733578HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD276 at 2 μg/ml can bind Anti-CD276 rabbit monoclonal antibody, the EC50 of human CD276 protein is 1.961-2.243 ng/ml.

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP007763HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP023997HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized TNFSF9 at 2 μg/ml can bind TNFRSF9(CSB-MP023984HU1), the EC50 is 2.671-3.702 ng/mL

CSB-MP001707HU(A4) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody(CSB-RA001707MA01HU), the EC50 is 0.6666-0.8876 ng/mL

CSB-MP019093HU(M) Activity Verified

FACS assay shows that Human PVR can bind to HEK293F cell overexpressing human TIGIT.

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 來源 蛋白標(biāo)簽
Recombinant Human Angiopoietin-2 (ANGPT2) (Active) CSB-MP001707HU(A4) ANGPT2 Mammalian cell C-terminal 10xHis-tagged
Recombinant Dog Angiopoietin-2 (ANGPT2) (Active) CSB-MP001707DO ANGPT2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active) CSB-MP733578HU CD276 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active) CSB-MP005165HU CEACAM5 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active) CSB-AP003591HU CSF2RA Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) CSB-MP007479HU EGFR Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active) CSB-MP007763HU ERBB2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active) CSB-MP007765HU ERBB3 Mammalian cell C-terminal hFc-tagged
Recombinant Human Fibronectin (FN1), partial (Active) CSB-AP005751HU FN1 E.coli Tag-Free
Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA), partial (Active) CSB-MP011649HU3 IL2RA Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Interleukin-4 receptor subunit alpha (IL4R), partial (Active) CSB-AP004271HU IL4R Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Interleukin-4 receptor subunit alpha (IL4R), partial (Active) CSB-AP004281HU IL4R Mammalian cell C-terminal Fc-tagged
Recombinant Human Interleukin-4 receptor subunit alpha (IL4R), partial,Biotinylated (Active) CSB-MP011661HU2-B IL4R Mammalian cell C-terminal 10xHis-Avi-tagged
Recombinant Human B-lymphocyte antigen CD20 (MS4A1)-VLPs (Active) CSB-MP015007HU MS4A1 Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Dog B-lymphocyte antigen CD20 (MS4A1)-VLPs (Active) CSB-MP661636DO MS4A1 Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Macaca fascicularis Membrane spanning 4-domains A1 (MS4A1)-VLPs (Active) CSB-MP4516MOV MS4A1 Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Programmed cell death protein 1 (PDCD1), partial (Active) CSB-MP619964HU1 PDCD1 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Poliovirus receptor (PVR) (I340M), partial (Active) CSB-MP019093HU(M) PVR Mammalian cell C-terminal hFc-tagged
Recombinant Human Transforming growth factor beta-1 proprotein (TGFB1), partial (Active) CSB-AP003861HU TGFB1 Mammalian cell Tag-Free
Recombinant Mouse Transforming growth factor beta-1 proprotein (Tgfb1), partial (Active) CSB-AP004111MO Tgfb1 Mammalian cell Tag-Free
Recombinant Human Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), partial (Active) CSB-MP023977HU1 TNFRSF1A Mammalian cell C-terminal hFc-tagged
Recombinant Human Tumor necrosis factor ligand superfamily member 9 protein (TNFSF9), partial (Active) CSB-AP001961HU TNFSF9 E.Coli Tag-Free
Recombinant Human Tumor necrosis factor ligand superfamily member 9 (TNFSF9), partial (Active) CSB-MP023997HU1 TNFSF9 Mammalian cell N-terminal hFc-Myc-tagged

● 重組抗體

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU
CSB-RA878942MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CD3E Recombinant Monoclonal Antibody
CSB-RA004931MA1HU
CSB-RA004931MA1HU FC

Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU
CSB-RA159341A0HU FC

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

FN1 Recombinant Monoclonal Antibody
CSB-RA919940A0HU
CSB-RA919940A0HU FC

Overlay Peak curve showing 3T3 cells stained with CSB-RA919940A0HU (red line) at 1:50.

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
ANGPT2 Recombinant Monoclonal Antibody CSB-RA191985A0HU ANGPT2 Human ELISA, IHC
ANGPT2 Recombinant Monoclonal Antibody CSB-RA001707MA01HU ANGPT2 Human ELISA
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD3E Recombinant Monoclonal Antibody CSB-RA004931MA1HU CD3E Human ELISA, FC
CD47 Recombinant Monoclonal Antibody CSB-RA802124A0HU CD47 Human ELISA, WB, IHC, IF
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA3HU CEACAM5 Human ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA1HU CEACAM5 Human ELISA
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody CSB-RA007479A1092phHU EGFR Human ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody CSB-RA007479A1068phHU EGFR Human ELISA, WB
EGFR Recombinant Monoclonal Antibody CSB-RA159341A0HU EGFR Human ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody CSB-RA794061A0HU EGFR Human ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU EGFR Human ELISA, IHC, FC
ERBB2 Recombinant Monoclonal Antibody CSB-RA260392A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA1HU ERBB2 Human ELISA
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody CSB-RA588766A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA2HU ERBB2 Human ELISA, IHC
ERBB3 Recombinant Monoclonal Antibody CSB-RA937008A0HU ERBB3 Human ELISA, IF
FN1 Recombinant Monoclonal Antibody CSB-RA921689A0HU FN1 Human ELISA, IHC

● ELISA試劑盒

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 檢測(cè)范圍 靈敏度
Bovine Angiopoietin-1(ANGPT1) ELISA kit CSB-EL001706BO ANGPT1 12.5 ng/mL-800 ng/mL 1.384 ng/mL
Human Angiopoietin-1(ANGPT1) ELISA kit CSB-EL001706HU ANGPT1 1.25 ng/mL-80 ng/mL 0.091 ng/mL
Mouse Angiopoietin 1,ANG-1 ELISA Kit CSB-E07302m ANGPT1 1.25 ng/mL-80 ng/mL 0.312 ng/mL
Rat Angiopoietin 1,ANG-1 ELISA Kit CSB-E07303r ANGPT1 6.25 ng/mL-400 ng/mL 1.56 ng/mL
Pig Angiopoietin 1,ANG-1 ELISA Kit CSB-E08457p ANGPT1 6 ng/mL-200 ng/mL 6 ng/mL
Human Angiopoietin 2,ANG-2 ELISA Kit CSB-E04500h ANGPT2 39 pg/mL-2500 pg/mL 9.75 pg/mL
Rat Angiopoietin 2,ANG-2 ELISA Kit CSB-E07304r ANGPT2 Request Information Request Information
Mouse Angiopoietin 2,ANG-2 ELISA Kit CSB-E07305m ANGPT2 0.156 pg/mL-10 pg/mL 0.039 pg/mL
Pig Angiopoietin 2,ANG-2 ELISA Kit CSB-E08460p ANGPT2 0.94 ng/mL-60 ng/mL 0.235 ng/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human Soluble CD276,sCD276/sB7-H3 ELISA Kit CSB-E14285h CD276 3.12 ng/mL-200 ng/mL 0.78 ng/mL
Human Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940HU CD47 3.12 pg/mL-200 pg/mL 0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940MO CD47 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Human carcinoembryonic antigen,CEA ELISA Kit CSB-E04767h CEACAM5 5 ng/mL-120 ng/mL 2 ng/mL
Mouse carcinoembryonic antign,CEA ELISA Kit CSB-E13925m CEACAM5 62.5 pg/mL-4000 pg/mL 15.6 pg/mL
Human epidermal growth factor receptor,EGFR ELISA Kit CSB-E12124h EGFR 0.312 ng/mL-20 ng/mL 0.019 ng/mL
Mouse Soluble Endoglin,ENG/sCD105 ELISA Kit CSB-E09921m ENG 6.25 ng/mL-400 ng/mL 1.56 ng/mL
Human Soluble Endoglin,sENG/sCD105 ELISA Kit CSB-E10030h ENG 0.156 ng/mL-10 ng/mL 0.047 ng/mL